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Terpenoids as Chemopreventive Agents and Their Interpretation in Animal Models and Human Clinical Trials

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Handbook of Animal Models and its Uses in Cancer Research

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Abstract

Cancer chemoprevention is described as the utilization of substances of natural or synthetic origin to interfere in the discrete early stages of cancer development and progression. This strategy ultimately targets the reversion, suppression, and prevention of the disease. Representative substances used for this purpose are the terpenoids. Terpenoids are naturally occurring compounds originating either from plants or animals or even bacteria and yeast as products of their secondary metabolism and are often already part of human diet. In this chapter, the chemopreventive action of extensively studied terpenoids will be investigated with focus on their in vivo activity in various animal models and results from clinical trials.

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Authors and Affiliations

  1. Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Siokatas Christos, Leonidis Georgios & Sarli Vasiliki

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  1. Siokatas Christos
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  2. Leonidis Georgios
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  3. Sarli Vasiliki
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Correspondence to Sarli Vasiliki .

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Editors and Affiliations

  1. Cancer Biology and Biotechnology Lab Faculty of Allied Health Sciences Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai, India

    Surajit Pathak

  2. Cancer Biology and Biotechnology Lab Faculty of Allied Health Sciences Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai, India

    Antara Banerjee

  3. AGENTEM (Adana Genetic Diseases Diagnosis and Treatment Center) & Medical Genetics Department of Medical Faculty, Cukurova University, Adana, Turkey

    Atil Bisgin

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Christos, S., Georgios, L., Vasiliki, S. (2023). Terpenoids as Chemopreventive Agents and Their Interpretation in Animal Models and Human Clinical Trials. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-3824-5_36

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