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Hematologic Disorders: Leukemia, Hyperviscosity, Anemia

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Pediatric Retinal Diseases

Part of the book series: Retina Atlas ((RA))

Abstract

Leukemia is the most common cancer in the pediatric population, accounting for nearly one out of three pediatric cancers. Most childhood leukemias are acute lymphocytic leukemia (ALL) and the remaining are acute myeloid leukemia (AML). In contrast, chronic leukemias are rare in childhood. Ocular findings are varied, but the retina is the most commonly involved tissue site in clinical studies. While direct retinal invasion by leukemic cells can occur, the majority of retinal findings are likely due to secondary hematologic changes. The term leukemic retinopathy often describes the manifestation of anemia and increased blood viscosity in patients with leukemia and are, therefore, topics included for review below.

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References

  • Adam MK, Pitcher JD, Shields CL, Maguire JI. Enhanced depth imaging optical coherence tomography of precursor cell leukemic choroidopathy before and after chemotherapy. Middle East Afr J Ophthalmol. 2015;22(2):249–52.

    Article  Google Scholar 

  • Allen RA, Straatsma BR. Ocular involvement in leukemia and allied disorders. Arch Ophthalmol. 1961;66:490–508.

    Article  CAS  Google Scholar 

  • Al-Rashid RA, Cress C. Mumps uveitis complicating the course of acute leukemia. J Pediatr Ophthalmol. 1977;14(2):100–2.

    CAS  PubMed  Google Scholar 

  • Clayman HM, Flynn JT, Koch K, Israel C. Retinal pigment epithelial abnormalities in leukemic disease. Am J Ophthalmol. 1972;74(3):416–9.

    Article  CAS  Google Scholar 

  • Cogan DG. Immunosuppression and eye disease. First Vail lecture. Am J Ophthalmol. 1977;83(6):777–88.

    Article  CAS  Google Scholar 

  • Duane TD, Osher RH, Green WR. White centered hemorrhages: their significance. Ophthalmology. 1980;87(1):66–9.

    Article  CAS  Google Scholar 

  • Gawai D, Jhavar S, Patil S. Orbital and ocular manifestations of acute and chronic leukemia. Int J Health Sci Res. 2016;6(9):61–4.

    Google Scholar 

  • Hutter JJ. Childhood leukemia. Pediatr Rev. 2010;31(6):234–41.

    Article  Google Scholar 

  • Karesh JW, Goldman EJ, Reck K, Kelman SE, Lee EJ, Schiffer CA. A prospective ophthalmic evaluation of patients with acute myeloid leukemia: correlation of ocular and hematologic findings. J Clin Oncol. 1989;7(10):1528–32.

    Article  CAS  Google Scholar 

  • Khan K, Malik AI, Almarzouqi SJ, Morgan ML, Yalamanchili S, Chevez-Barrios P, Lee AG. Optic neuropathy due to chronic lymphocytic leukemia proven with optic nerve sheath biopsy. J Neuroophthalmol. 2016;36(1):61–6.

    Article  Google Scholar 

  • Kim TS, Duker JS, Hedges TR III. Retinal angiopathy resembling unilateral frosted branch angiitis in a patient with relapsing acute lymphoblastic leukemia. Am J Ophthalmol. 1994;117(6):806–8.

    Article  CAS  Google Scholar 

  • Kincaid MC, Green WR. Ocular and orbital involvement in leukemia. Surv Ophthalmol. 1983;27(4):211–32.

    Article  CAS  Google Scholar 

  • Kincaid MC, Green WR, Kelley JS. Acute ocular leukemia. Am J Ophthalmol. 1979;87(5):698–702.

    Article  CAS  Google Scholar 

  • Kuwabara T. Leukemic miliary nodules in the retina. Arch Ophthalmol. 1964;72:494–7.

    Article  CAS  Google Scholar 

  • Le JQ, Braich PS, Brar VS. Optical coherence tomography findings of bilateral foveal leukemic infiltration. Int Med Case Rep J. 2016;9:237–40.

    Article  Google Scholar 

  • Leonardy NJ, Rupani M, Dent G, Klintworth GK. Analysis of 135 autopsy eyes for ocular involvement in leukemia. Am J Ophthalmol. 1990;109(4):436–44.

    Article  CAS  Google Scholar 

  • Mehta J, Wang H, Iqbal SU, Mesa R. Epidemiology of myeloproliferative neoplasms in the United States. Leuk Lymphoma. 2014;55(3):595–600.

    Article  Google Scholar 

  • Meredith TA, Aaberg TM, Reeser FH. Rhegmatogenous retinal detachment complicating cytomegalovirus retinitis. Am J Ophthalmol. 1979;87(6):793–6.

    Article  CAS  Google Scholar 

  • Merle H, Hage R, Meniane JC, Deligny C, Plumelle Y, Donnio A, Jean-Charles A. Retinal manifestations in adult T-cell leukemia/lymphoma related to infection by the human T-cell lymphotropic virus type-1. Retina. 2016;36(7):1364–71.

    Article  CAS  Google Scholar 

  • Nerkelun S, Kellermann S, Nenning H. Acute blindness caused by fungal infection in chronic myeloid leukemia. Klin Monatsbl Augenheilkd. 1997;211(4):272–4.

    Article  CAS  Google Scholar 

  • Orellana J, Friedman AH. Ocular manifestations of multiple myeloma, Waldenstrom’s macroglobulinemia and benign monoclonal gammopathy. Surv Ophthalmol. 1981;26(3):157–69.

    Article  CAS  Google Scholar 

  • Pears MA, Pickering GW. Changes in the fundus oculi after haemorrhage. Q J Med. 1960;29:153–78.

    CAS  PubMed  Google Scholar 

  • Reddy SC, Jackson N, Menon BS. Ocular involvement in leukemia–a study of 288 cases. Ophthalmologica. 2003;217(6):441–5.

    Article  CAS  Google Scholar 

  • Salazar Mendez R, Fonolla Gil M. Unilateral optic disk edema with central retinal artery and vein occlusions as the presenting signs of relapse in acute lymphoblastic leukemia. Arch Soc Esp Oftalmol. 2014;89(11):454–8.

    CAS  PubMed  Google Scholar 

  • Samia L, Hamam R, Dbaibo G, Saab R, El-Solh H, Abboud M, Muwakkit S. Cytomegalovirus retinitis in children and young adults with acute lymphoblastic leukemia in Lebanon. Leuk Lymphoma. 2014;55(8):1918–21.

    Article  Google Scholar 

  • Schachat AP, Markowitz JA, Guyer DR, Burke PJ, Karp JE, Graham ML. Ophthalmic manifestations of leukemia. Arch Ophthalmol. 1989;107(5):697–700.

    Article  CAS  Google Scholar 

  • Schworm HD, Nasemann JE, Schriever S. Subretinal hypopyon in prolymphocytic leukaemia. Br J Ophthalmol. 1995;79(9):863–4.

    Article  CAS  Google Scholar 

  • Sharma H, Majumder PD, Rao C, Biswas J. A case of acute myeloid leukemia masquerading as unilateral exudative detachment. Am J Ophthalmol Case Rep. 2016;4:47–9.

    Article  Google Scholar 

  • Silva RA, Young R, Sridhar J, G. Nocardia Study. Nocardia choroidal abscess: risk factors, treatment strategies, and visual outcomes. Retina. 2015;35(10):2137–46.

    Article  Google Scholar 

  • Swartz M, Schumann GB. Acute leukemic infiltration of the vitreous diagnosed by pars plana aspiration. Am J Ophthalmol. 1980;90(3):326–30.

    Article  CAS  Google Scholar 

  • Yalcinbayir O, Baytan B, Gelisken O, Can B, Sezgin Evim M, Yildiz M, Meral Gunes A. Spectral domain optical coherence tomography findings of patients under treatment for pediatric acute lymphoblastic leukemia. J AAPOS. 2017;21(2):131–135 e131.

    Article  Google Scholar 

  • Zhioua R, Boussen I, Malek I, Ouertani A. Acute lymphoblastic leukemia and vitreous infiltration. A case study. J Fr Ophtalmol. 2001;24(2):180–2.

    CAS  PubMed  Google Scholar 

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Correspondence to Ingrid U. Scott .

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Moreno, T., Kim, S.J., Scott, I.U. (2022). Hematologic Disorders: Leukemia, Hyperviscosity, Anemia. In: Chan, R.V.P. (eds) Pediatric Retinal Diseases. Retina Atlas. Springer, Singapore. https://doi.org/10.1007/978-981-19-1364-8_11

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  • DOI: https://doi.org/10.1007/978-981-19-1364-8_11

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-1363-1

  • Online ISBN: 978-981-19-1364-8

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