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Brain Infectious Diseases and Nanotherapy

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Nanotechnology for Infectious Diseases

Abstract

Indubitably brain is a highly complex organ and has the responsibility to regulate all the cognitive, behavioral, and emotional activities. The meninges and blood–brain barrier act as a safeguard to protect it from pathogenic attacks and blood-borne insults, however, the absence of an indigenous defense mechanism makes it an easy target for many diseases and disorders. Infectious diseases are the main reason for casualties, long-term disability, and economic hardship and negatively impacting healthcare and socioeconomic development on a global scale. For decades, the scientific community struggled to produce medications that can trespass the barriers of the brain and target the intended locations with minimum side effects. However, most of the promising drugs, which proved to enhance brain repair and function at the laboratory stage in animal models, confront numerous hurdles, including specificity, delivery, development of resistance, and toxicity. Thus the development of new techniques is a prerequisite. Nanotechnology is a technique that can modify substances at the molecular level to achieve the desired structure. The nanostructures, interacting with microorganisms, are rapidly transforming the biomedical area, providing benefits in both diagnostic and therapeutic applications. This chapter gives a basic overview of how nanosized materials can be used to diagnose and treat common brain infections.

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Author notes

  1. Maharudra Pratap Singh and Santosh Kumar Yadav contributed equally and share equal first co-authorship.

Authors and Affiliations

  1. Laboratory for Stem Cell and Restorative Neurology, Department of Biotechnology, Era’s Lucknow Medical College Hospital, Era University, Lucknow, India

    Maharudra Pratap Singh, Santosh Kumar Yadav & Syed Shadab Raza

  2. Department of Biotechnology, Central University of South Bihar, Gaya, India

    Maharudra Pratap Singh & Rizwanul Haque

  3. Department of Pharmaceutics, Centre for Pharmaceutical Nanotechnology, National Institute of Pharmaceutical Education and Research, S.A.S Nagar, Sector 67, Mohali, Punjab, India

    Mohammad Meraj Khan

  4. Department of Pathology, Era’s Lucknow Medical College Hospital, Era University, Lucknow, India

    Sharique Ahmad

  5. Institute of Nanoscience and Technology, Mohali, India

    Rehan Khan

  6. Hammad Medical Co-operation, Doha, Qatar

    Abdul Quaiyoom Khan

  7. Department of Stem Cell Biology and Regenerative Medicine, Era University, Lucknow, India

    Syed Shadab Raza

Authors
  1. Maharudra Pratap Singh
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  2. Santosh Kumar Yadav
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  3. Mohammad Meraj Khan
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  4. Sharique Ahmad
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  5. Rehan Khan
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  6. Abdul Quaiyoom Khan
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  7. Rizwanul Haque
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  8. Syed Shadab Raza
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Corresponding author

Correspondence to Syed Shadab Raza .

Editor information

Editors and Affiliations

  1. Amity Institute of Biotechnology, Amity University Haryana, Gurugram, India

    Saif Hameed

  2. Epidemic Disease Research, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

    Suriya Rehman

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Singh, M.P. et al. (2022). Brain Infectious Diseases and Nanotherapy. In: Hameed, S., Rehman, S. (eds) Nanotechnology for Infectious Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-16-9190-4_26

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