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Methods and Parameter Optimization of Manufacturing Process Using Alginate-Based Hydrogel Bioinks

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Recent Advances in Manufacturing Processes and Systems

Part of the book series: Lecture Notes in Mechanical Engineering ((LNME))

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Abstract

The application of additive manufacturing (AM) technology in biomedicine offers many advantages due to the possibility of personalization and precision in shape accurate reproduction or dose of drug selection. AM technique enables the use of a wide variety of biocompatible materials, which can be applied even in the form of hydrogel. However, the use of sodium alginate as a bioink is encountered with some difficulties, for example, problem with shape retention during fabrication before being cross-linked. In this paper, methods used in extrusion-based method that contributes to maintaining the precision and quality of the print by reducing the spill ability of alginate hydrogel are described. This paper presents one of the methods, which supports the alginate hydrogel manufacturing process—freeform reversible embedding of suspended hydrogels (FRESH), as well as the optimization of the manufacturing process parameters to improve the quality of prints.

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Author information

Authors and Affiliations

  1. Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, Wroclaw, Poland

    M. B. Łabowska & J. Detyna

  2. Center for Advanced Manufacturing Technologies (CAMT/FPC), Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, Wroclaw, Poland

    P. Szymczyk-Ziółkowska

  3. Department of Advanced Material Technologies, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland

    I. Michalak

Authors
  1. M. B. Łabowska
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  2. P. Szymczyk-Ziółkowska
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  3. I. Michalak
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  4. J. Detyna
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Corresponding author

Correspondence to M. B. Łabowska .

Editor information

Editors and Affiliations

  1. Department of Mechanical Engineering, S. V. National Institute of Technology, Surat, Gujarat, India

    Harshit K. Dave

  2. Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

    Uday Shanker Dixit

  3. Gheorghe Asachi Technical University of lasi, Iasi, Romania

    Dumitru Nedelcu

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© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Łabowska, M.B., Szymczyk-Ziółkowska, P., Michalak, I., Detyna, J. (2022). Methods and Parameter Optimization of Manufacturing Process Using Alginate-Based Hydrogel Bioinks. In: Dave, H.K., Dixit, U.S., Nedelcu, D. (eds) Recent Advances in Manufacturing Processes and Systems. Lecture Notes in Mechanical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-16-7787-8_54

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  • DOI: https://doi.org/10.1007/978-981-16-7787-8_54

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-7786-1

  • Online ISBN: 978-981-16-7787-8

  • eBook Packages: EngineeringEngineering (R0)

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