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Topological Polymer Chemistry pp 159–176Cite as

Programmed Polymer Folding

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Abstract

In this chapter, we discuss emerging concepts and tools for engineering molecular folds. We focus on linear polymers including engineered proteins and DNA as well as polymers of non-biological origins. We outline the implications of fold topology for the kinetics of folding reactions and the stability of the synthesized fold. The relation between topology and molecular properties including mechanical response to external forces will be discussed. For the desired topology, we will examine monomer chemistry options and available synthesis protocols. The chapter will end with a perspective of future challenges and possibilities in programmed polymer folding.

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Author information

Authors and Affiliations

  1. Faculty of Science, Leiden University, Einsteinweg 55, 2333CC, Leiden, The Netherlands

    Laurens W. H. J. Heling, Vahid Satarifard & Alireza Mashaghi

  2. Department of Medical Biochemistry and Biophysics, Karolinska Institute, Biomedicum, Solnavägen 9, 17177, Stockholm, Sweden

    Seyedeh Elnaz Banijamali

  3. Department of Theory and Biosystems, Max Planck Institute of Colloids and Interfaces, 14424, Potsdam, Germany

    Vahid Satarifard

Authors
  1. Laurens W. H. J. Heling
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  2. Seyedeh Elnaz Banijamali
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  3. Vahid Satarifard
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  4. Alireza Mashaghi
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Corresponding author

Correspondence to Alireza Mashaghi .

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Editors and Affiliations

  1. Tokyo Institute of Technology, Tokyo, Japan

    Yasuyuki Tezuka

  2. Ochanomizu University, Tokyo, Japan

    Tetsuo Deguchi

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Heling, L.W.H.J., Banijamali, S.E., Satarifard, V., Mashaghi, A. (2022). Programmed Polymer Folding. In: Tezuka, Y., Deguchi, T. (eds) Topological Polymer Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-16-6807-4_11

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