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Stemness and Stromal Niche: Targets in Oxidative Stress–Induced Oral Cancer

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Oral cancer is the third most prevalent cancer in the world and the most common among males. Despite improvement in therapeutic strategies, the overall prognosis of oral cancer has remained poor. A subpopulation of cancer cells, known as cancer stem cells (CSCs) and its interaction with tumor microenvironment (TME), drives aggressive behavior of cancer. Excess of pro-oxidant components induces oxidative stress in both cancer cells and TME and plays critical roles in the neoplastic outcomes of the oral cavity. However, CSCs have intrinsic ability to maintain low oxidative stress status and metabolic plasticity which allows it to thrive in high oxidative stress conditions. In this chapter, we have discussed the role of oxidative stress in CSCs and stromal microenvironment of oral cancer and available therapeutic options against it.

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Acknowledgments

This work is supported by the intramural grant from NIBMG. KV acknowledges DST-INSPIRE, SG acknowledges DBT and PM and PP acknowledges CSIR for fellowship support.

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Author notes

  1. Subhashis Ghosh, Paromita Mitra and Kavya Vipparthi contributed equally with all other contributors.

Authors and Affiliations

  1. National Institute of Biomedical Genomics, Kalyani, West Bengal, India

    Subhashis Ghosh, Paromita Mitra, Kavya Vipparthi, Priyanka Prasad & Sandeep Singh

  2. Receptor Biology and Tumor Metastasis, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India

    Priyanka Prasad

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  1. Subhashis Ghosh
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  2. Paromita Mitra
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  3. Kavya Vipparthi
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  4. Priyanka Prasad
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  5. Sandeep Singh
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Corresponding author

Correspondence to Sandeep Singh .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Cellular Stress and Immune Response Laboratory, Centre for Cancer Biology, University of South Australia, Adelaide, South Australia, Australia

    Nirmal Robinson

  2. Department of Morphofunctional Sciences, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

    Cornelia Amalinei

  3. Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India

    Amitava Das

  4. Biological Sciences, Academy of Scientific and Innovative Research, Ghaziabad,, UP, India

    Amitava Das

  5. Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chennai, Tamil Nadu, India

    Surajit Pathak

  6. Stem Cell Facility, DBT-Centre of Excellence for Stem Cell Research, All India Institute of Medical Sciences, New Delhi, India

    Sujata Mohanty

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Ghosh, S., Mitra, P., Vipparthi, K., Prasad, P., Singh, S. (2022). Stemness and Stromal Niche: Targets in Oxidative Stress–Induced Oral Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_92

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