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Oxidative Stress Associated Non-coding RNAs in Pathogenesis of Urologic Cancers: Prognostic and Therapeutic Importance

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

In understanding the role of non-coding RNA in the pathogenesis of oxidative stress-induced urologic cancer, the present study focused on available data of miR-21, an oncogenic miRNA from published literature, in the malignancy of human prostate. miR-21 is over-expressed under oxidative stress, and it serves as a mediator to upregulate ROS (reactive oxygen species) induced signaling pathways including AR (androgen receptor), PI3K/Akt, RTK/ERK, and so on during carcinogenesis of prostate. In prostate cancer, association of miR-21 with aggressive tumor phenotypes, poor patient survival, and differential response of patients to conventional treatment measures indicated its (miR-21) potency to predict disease outcome as a prognostic biomarker. In the body fluid of patients, availability of miR-21 and its prognostic value may be explored to evaluate disease outcomes in non-invasive methods. miR-21 has been targeted therapeutically by synthetic and naturally occurring substances with significant suppression of tumorigenicity of cancer cells. However extensive in vivo research is warranted with therapeutic measures to determine the effective dose and to develop suitable delivery system for initiating their bedside implementation.

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Acknowledgments

We are thankful to the Hon’ble Vice Chancellor, Presidency University Kolkata, India. Financial support for this work was provided by the West Bengal State Govt. sponsored Presidency University FRPDF funds to Dr. Amlan Ghosh.

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Authors and Affiliations

  1. Genetics of Non-communicable Diseases, Department of Life Sciences, Presidency University, Kolkata, India

    Abhishek Bardhan & Amlan Ghosh

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  1. Abhishek Bardhan
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  2. Amlan Ghosh
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Correspondence to Amlan Ghosh .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

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  1. CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India

    Suvendranath Bhattacharyya

  2. Dept of Toxicology, University of Belgrade, Belgrade, Serbia

    Aleksandra Buha Dordevic

  3. Human Genetics Unit, Indian Statistical Institute, Kolkata, West Bengal, India

    Nilabja Sikdar

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Bardhan, A., Ghosh, A. (2022). Oxidative Stress Associated Non-coding RNAs in Pathogenesis of Urologic Cancers: Prognostic and Therapeutic Importance. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_236

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