Abstract
Excessive production of reactive oxygen species in the system is the cause of various diseases. This in turn causes stress in the body, which must be reduced. Research shows that secondary metabolites have the property to reduce excessive reactive oxygen species and the risk of related chronic disorders. Plant-derived secondary metabolites are enriched with biological active compounds which have beneficial effects to humans. Dietary alkaloids and antioxidants have inherent properties like anti-inflammatory, anticancer, antidiabetic, and neuroprotection, which makes them a potential lead in the prognosis of disorders. Recent studies on phytochemicals, antioxidants, and alkaloids have shown promising effects for therapeutic approach against diseases.
This is a preview of subscription content, log in via an institution to check access.
References
Adams DJ, Dai M, Pellegrino G, Wagner BK, Stern AM, Shamji AF, Schreiber SL (2012) Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs. Proc Natl Acad Sci 109(38):15115–15120. https://doi.org/10.1073/pnas.1212802109
Ahmadiankia N, Moghaddam HK, Mishan MA, Bahrami R, Naderi-Meshkin H, Bidkhori HR, Moghaddam M, Mirfeyzi SJA (2016) Berberine suppresses migration of MCF-7 breast cancer cells through down-regulation of chemokine receptors. Iran J Basic Med Sci 19(2):7
Ahmed OM (2018) Relationships between oxidative stress, cancer development and therapeutic interventions. J Cancer Sci Res 02(01). https://doi.org/10.4172/2576-1447.1000e104
Atanasov AG, Waltenberger B, Pferschy-Wenzig E-M, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM, Schuster D, Breuss JM, Bochkov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H (2015) Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnol Adv 33(8):1582–1614. https://doi.org/10.1016/j.biotechadv.2015.08.001
Bezerra DP, Pessoa C, de Moraes MO, Saker-Neto N, Silveira ER, Costa-Lotufo LV (2013) Overview of the therapeutic potential of piplartine (piperlongumine). Eur J Pharm Sci 48(3):453–463. https://doi.org/10.1016/j.ejps.2012.12.003
Chen C, Lin L (2020) Alkaloids in Diet. In: Xiao J, Sarker SD, Asakawa Y (eds) Handbook of dietary phytochemicals. Springer Singapore, Singapore, pp 1–35. https://doi.org/10.1007/978-981-13-1745-3_36-1
Costa AGV, Garcia-Diaz DF, Jimenez P, Silva PI (2013) Bioactive compounds and health benefits of exotic tropical red–black berries. J Funct Foods 5(2):539–549. https://doi.org/10.1016/j.jff.2013.01.029
Cragg GM, Newman DJ (2013) Natural products: a continuing source of novel drug leads. Biochim Biophys Acta Gen Subj 1830(6):3670–3695. https://doi.org/10.1016/j.bbagen.2013.02.008
Dasari S, Bakthavachalam V, Chinnapaka S, Venkatesan R, Samy ALPA, Munirathinam G (2020) Neferine, an alkaloid from lotus seed embryo targets HeLa and SiHa cervical cancer cells via pro-oxidant anticancer mechanism. Phytother Res:ptr.6687. https://doi.org/10.1002/ptr.6687
Debnath B, Singh WS, Das M, Goswami S, Singh MK, Maiti D, Manna K (2018) Role of plant alkaloids on human health: a review of biological activities. Mater Today Chem 9:56–72. https://doi.org/10.1016/j.mtchem.2018.05.001
Deng G-F, Lin X, Xu X-R, Gao L-L, Xie J-F, Li H-B (2013) Antioxidant capacities and total phenolic contents of 56 vegetables. J Funct Foods 5(1):260–266. https://doi.org/10.1016/j.jff.2012.10.015
Farnsworth N, Akerele O, Bingel A (1987) Medicinal plants in therapy. J Ethnopharmacol 19(3):336. https://doi.org/10.1016/0378-8741(87)90016-X
Fu L, Xu B-T, Xu X-R, Qin X-S, Gan R-Y, Li H-B (2010) Antioxidant capacities and Total phenolic contents of 56 wild fruits from South China. Molecules 15(12):8602–8617. https://doi.org/10.3390/molecules15128602
Golovine K, Makhov P, Naito S, Raiyani H, Tomaszewski J, Mehrazin R, Tulin A, Kutikov A, Uzzo RG, Kolenko VM (2015) Piperlongumine and its analogs down-regulate expression of c-Met in renal cell carcinoma. Cancer Biol Ther 16(5):743–749. https://doi.org/10.1080/15384047.2015.1026511
Greenshields AL, Doucette CD, Sutton KM, Madera L, Annan H, Yaffe PB, Knickle AF, Dong Z, Hoskin DW (2015) Piperine inhibits the growth and motility of triple-negative breast cancer cells. Cancer Lett 357(1):129–140. https://doi.org/10.1016/j.canlet.2014.11.017
Guamán Ortiz LM, Tillhon M, Parks M, Dutto I, Prosperi E, Savio M, Arcamone AG, Buzzetti F, Lombardi P, Scovassi AI (2014) Multiple effects of Berberine derivatives on colon cancer cells. Biomed Res Int 2014:1–12. https://doi.org/10.1155/2014/924585
Gunasekaran V, Elangovan K, Niranjali Devaraj S (2017) Targeting hepatocellular carcinoma with piperine by radical-mediated mitochondrial pathway of apoptosis: an in vitro and in vivo study. Food Chem Toxicol 105:106–118. https://doi.org/10.1016/j.fct.2017.03.029
Jyothi D, Vanathi P, Mangala Gowri P, Rama Subba Rao V, Madhusudana Rao J, Sreedhar AS (2009) Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba. Toxicol In Vitro 23(6):1085–1091. https://doi.org/10.1016/j.tiv.2009.05.023
Khajuria A., Thusu N, Zutshi U, Bedi KL (n.d.) Piperine modulation of carcinogen induced oxidative stress in intestinal mucosa. 6
Kumar M, Kumar S, Kaur S (2012) Role of ROS and COX-2/iNOS inhibition in cancer chemoprevention: a review. Phytochem Rev 11(2–3):309–337. https://doi.org/10.1007/s11101-012-9265-1
Lai L, Fu Q, Liu Y, Jiang K, Guo Q, Chen Q, Yan B, Wang Q, Shen J (2012) Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model. Acta Pharmacol Sin 33(4):523–530. https://doi.org/10.1038/aps.2011.209
Li Q, Chen L, Dong Z, Zhao Y, Deng H, Wu J, Wu X, Li W (2019) Piperlongumine analogue L50377 induces pyroptosis via ROS mediated NF-κB suppression in non-small-cell lung cancer. Chem Biol Interact 313:108820. https://doi.org/10.1016/j.cbi.2019.108820
Lu J-J, Bao J-L, Chen X-P, Huang M, Wang Y-T (2012) Alkaloids isolated from natural herbs as the anticancer agents. Evid Based Complement Alternat Med 2012:1–12. https://doi.org/10.1155/2012/485042
Maiti M, Kumar GS (2010) Polymorphic nucleic acid binding of bioactive Isoquinoline alkaloids and their role in cancer. J Nucleic Acids 2010:1–23. https://doi.org/10.4061/2010/593408
Marthandam Asokan S, Mariappan R, Muthusamy S, Velmurugan BK (2018) Pharmacological benefits of neferine—A comprehensive review. Life Sci 199:60–70. https://doi.org/10.1016/j.lfs.2018.02.032
Mondal A, Gandhi A, Fimognari C, Atanasov AG, Bishayee A (2019) Alkaloids for cancer prevention and therapy: current progress and future perspectives. Eur J Pharmacol 858:172472. https://doi.org/10.1016/j.ejphar.2019.172472
Noda N, Wakasugi H (n.d.) Cancer and oxidative stress. 5
Patel K, Gadewar M, Tripathi R, Prasad S, Patel DK (2012) A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid “Harmine”. Asian Pac J Trop Biomed 2(8):660–664. https://doi.org/10.1016/S2221-1691(12)60116-6
Pham D-C, Chang Y-C, Lin S-R, Fuh Y-M, Tsai M-J, Weng C-F (2018) FAK and S6K1 inhibitor, Neferine, dually induces autophagy and apoptosis in human neuroblastoma cells. Molecules 23(12):3110. https://doi.org/10.3390/molecules23123110
Piska K, Gunia-Krzyżak A, Koczurkiewicz P, Wójcik-Pszczoła K, Pękala E (2018) Piperlongumine (piplartine) as a lead compound for anticancer agents – synthesis and properties of analogues: a mini-review. Eur J Med Chem 156:13–20. https://doi.org/10.1016/j.ejmech.2018.06.057
Poornima P, Weng CF, Padma VV (2014) Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest: Neferine induces intrinsic apoptotic pathway in A549 cells. Biofactors 40(1):121–131. https://doi.org/10.1002/biof.1115
Prasath M, Narasimha MB, Chih-Yang H, Viswanadha VP (2019) Neferine and isoliensinine from Nelumbo nucifera induced reactive oxygen species (ROS)-mediated apoptosis in colorectal cancer HCT-15 cells. Afr J Pharm Pharmacol 13(8):90–99. https://doi.org/10.5897/AJPP2019.5036
Qiu S, Sun H, Zhang A-H, Xu H-Y, Yan G-L, Han Y, Wang X-J (2014) Natural alkaloids: basic aspects, biological roles, and future perspectives. Chin J Nat Med 12(6):401–406. https://doi.org/10.1016/S1875-5364(14)60063-7
Randhawa H, Kibble K, Zeng H, Moyer MP, Reindl KM (2013) Activation of ERK signaling and induction of colon cancer cell death by piperlongumine. Toxicol In Vitro 27(6):1626–1633. https://doi.org/10.1016/j.tiv.2013.04.006
Rather RA, Bhagat M (2018) Cancer chemoprevention and Piperine: molecular mechanisms and therapeutic opportunities. Front Cell Dev Biol 6:10. https://doi.org/10.3389/fcell.2018.00010
Sivalingam KS, Paramasivan P, Weng CF, Viswanadha VP (2017) Neferine potentiates the antitumor effect of cisplatin in human lung adenocarcinoma cells via a mitochondria-mediated apoptosis pathway: N EFERINE P OTENTIATES A NTITUMOR E FFECT OF C ISPLATIN. J Cell Biochem 118(9):2865–2876. https://doi.org/10.1002/jcb.25937
Sun Y, Xun K, Wang Y, Chen X (2009) A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs. Anti-Cancer Drugs 20(9):757–769. https://doi.org/10.1097/CAD.0b013e328330d95b
Tripathi SK, Biswal BK (2020) Piperlongumine, a potent anticancer phytotherapeutic: perspectives on contemporary status and future possibilities as an anticancer agent. Pharmacol Res 156:104772. https://doi.org/10.1016/j.phrs.2020.104772
Wang F, Mao Y, You Q, Hua D, Cai D (2015) Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway. Int J Immunopathol Pharmacol 28(3):362–373. https://doi.org/10.1177/0394632015598849
Wang Y, Liu Y, Du X, Ma H, Yao J (2020) The anti-cancer mechanisms of Berberine: a review. Cancer Manag Res 12:695–702. https://doi.org/10.2147/CMAR.S242329
Xu L, Zhang X, Li Y, Lu S, Lu S, Li J, Wang Y, Tian X, Wei J, Shao C, Liu Z (2016) Neferine induces autophagy of human ovarian cancer cells via p38 MAPK/JNK activation. Tumor Biol 37(7):8721–8729. https://doi.org/10.1007/s13277-015-4737-8
Yaffe PB, Power Coombs MR, Doucette CD, Walsh M, Hoskin DW (2015) Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress: PIPERINE INHIBITS COLON CANCER CELL GROWTH. Mol Carcinog 54(10):1070–1085. https://doi.org/10.1002/mc.22176
Yamaguchi Y, Kasukabe T, Kumakura S (2018) Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis. Int J Oncol. https://doi.org/10.3892/ijo.2018.4259
Zhang Y-J, Gan R-Y, Li S, Zhou Y, Li A-N, Xu D-P, Li H-B (2015) Antioxidant phytochemicals for the prevention and treatment of chronic diseases. Molecules 20(12):21138–21156. https://doi.org/10.3390/molecules201219753
Zhang Y, Ma H, Wu Y, Wu Z, Yao Z, Zhang W, Zhuang C, Miao Z (2017) Novel non-trimethoxylphenyl piperlongumine derivatives selectively kill cancer cells. Bioorg Med Chem Lett 27(11):2308–2312. https://doi.org/10.1016/j.bmcl.2017.04.035
Zhang C, Sheng J, Li G, Zhao L, Wang Y, Yang W, Yao X, Sun L, Zhang Z, Cui R (2020a) Effects of Berberine and its derivatives on cancer: a systems pharmacology review. Front Pharmacol 10:1461. https://doi.org/10.3389/fphar.2019.01461
Zhang Q, Wang X, Cao S, Sun Y, He X, Jiang B, Yu Y, Duan J, Qiu F, Kang N (2020b) Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways. Biomed Pharmacother 128:110245. https://doi.org/10.1016/j.biopha.2020.110245
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Section Editor information
Rights and permissions
Copyright information
© 2022 Springer Nature Singapore Pte Ltd.
About this entry
Cite this entry
Shahagadkar, P., Munirathinam, G. (2022). Natural Dietary Alkaloids and Its Synthetic Derivatives as Oxidative Stress-Inducing Agents for Cancer Therapy. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_2
Download citation
DOI: https://doi.org/10.1007/978-981-16-5422-0_2
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-16-5421-3
Online ISBN: 978-981-16-5422-0
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences