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Oxidative Stress-Related Mechanisms That Mediate Chemoresistance in Cancer Stem Cells

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Cancer stem cells (CSCs) or tumor-initiating cells (TICs) are cellular progenitors involved in tumor progression, as well as in high therapeutic resistance and disease recurrence. Chemotherapy and ionizing radiation are ROS-inducible DNA damage, with focus on cellular increased proliferation cells. Reactive oxygen species (ROS) are chemical species related to several metabolic pathways, playing a double-edged sword, usually kept in balance through a range of exogenous and endogenous antioxidant systems, representing the so-called redox axis. However, when this axis is unbalanced, the increased levels of ROS can damage cellular structures and lead to DNA damage and cell death. Hereby, we describe the redox mechanisms involved in CSCs as a determinant for poor therapeutic responses.

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Author notes

  1. Geise Ellen Broto, Janaína Carla da Silva, Stefania Tagliari de Oliveira, Matheus Ricardo Garbim, Mariane Okamoto Oliveira and Carolina Panis contributed equally with all other contributors.

Authors and Affiliations

  1. Laboratory of Tumor Biology, Post-Graduation Program in Applied Health Sciences, State University of West Paraná, Unioeste, Francisco Beltrão, PR, Brazil

    Geise Ellen Broto, Janaína Carla da Silva, Stefania Tagliari de Oliveira, Matheus Ricardo Garbim, Mariane Okamoto Oliveira & Carolina Panis

  2. Post-Graduation Program in Clinical and Laboratory Physiopathology, State University of Londrina, Londrina, PR, Brazil

    Geise Ellen Broto & Carolina Panis

Authors
  1. Geise Ellen Broto
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  2. Janaína Carla da Silva
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  3. Stefania Tagliari de Oliveira
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  4. Matheus Ricardo Garbim
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  5. Mariane Okamoto Oliveira
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  6. Carolina Panis
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Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Cellular Stress and Immune Response Laboratory, Centre for Cancer Biology, University of South Australia, Adelaide, South Australia, Australia

    Nirmal Robinson

  2. Department of Morphofunctional Sciences, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

    Cornelia Amalinei

  3. Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India

    Amitava Das

  4. Biological Sciences, Academy of Scientific and Innovative Research, Ghaziabad,, UP, India

    Amitava Das

  5. Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chennai, Tamil Nadu, India

    Surajit Pathak

  6. Stem Cell Facility, DBT-Centre of Excellence for Stem Cell Research, All India Institute of Medical Sciences, New Delhi, India

    Sujata Mohanty

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Broto, G.E., da Silva, J.C., de Oliveira, S.T., Garbim, M.R., Oliveira, M.O., Panis, C. (2022). Oxidative Stress-Related Mechanisms That Mediate Chemoresistance in Cancer Stem Cells. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_101

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