Abstract
Marine polymers are a great group of macromolecules of interest for biomedical applications due to their biocompatibility, nontoxicity, and physical, chemical, structural, and pharmacological features. There are two possibilities to apply them for central nervous system (CNS) diseases: (a) as active substances (some marine polymers has biological activity per se and can be explored due to their pharmacological properties for diseases treatments) and (b) as materials (other marine polymers are excellent candidates as nano- or micro-vehicles to encapsulate drugs in order to overcome blood-brain barrier (BBB) access limitations or even target a specific area in the CNS). In this chapter, a brief anatomical/physiological review of the central nervous system and the blood-brain barrier, as well as the main drug access routes and limitations to target injured areas, will be carried out. The most common pathologies will be addressed with an emphasis on the therapeutic target of each of them, and the current applications described of marine polymers for central nervous system pathologies will be reviewed. The study revealed that marine polymers have a great potential for their application in CNS formulations and that a lot of research in this field is required to explore all the potential of these aquatic substances.
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Sánchez-Dengra, B., Bermejo, M., González-Álvarez, I., González-Álvarez, M. (2022). Marine-Based Biopolymers for Central Nervous System Drug Delivery. In: Jana, S., Jana, S. (eds) Marine Biomaterials . Springer, Singapore. https://doi.org/10.1007/978-981-16-4787-1_10
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