Skip to main content
SpringerLink
Log in

Recurrent Breast Cancer (Local and Metastatic): Surgical Aspects

  • Chapter
  • First Online:
Breast Cancer

  • 1685 Accesses

Abstract

Cancer recurrence is devastating for any patient, and challenging for the treating physician. Appropriate workup and optimal treatment at first diagnosis are the most important factors affecting chances of long term control. While inadequacies in delivery of standard treatment are important, there are many other factors like host and tumour biology that also influence the chance of recurrence. Recurrence may be loco-regional, distant or both, and treatment of these patients needs to be individualised.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Wapnir IL, Anderson SJ, Mamounas EP, et al. Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in five National Surgical Adjuvant Breast and Bowel Project node-positive adjuvant breast cancer trials. J Clin Oncol. 2006;24:2028–37.

    Google Scholar 

  2. Kamby C, Ejlertsen B, Andersen J, et al. The pattern of metastases in human breast cancer. Influence of systemic adjuvant therapy and impact on survival. Acta Oncol. 1988;27:715–9.

    CAS  Google Scholar 

  3. Kamby C, Vejborg I, Kristensen B, Olsen LO, Mouidsen HT. Metastatic pattern in recurrent breast cancer. Special reference to intrathoracic recurrences. Cancer. 1988;62:2226–33.

    CAS  Google Scholar 

  4. Jeong Y, Kim SS, Gong G, et al. Treatment results of breast cancer patients with locoregional recurrence after mastectomy. Radiat Oncol J. 2013;31:138–46. https://doi.org/10.3857/roj.2013.31.3.138.

    Google Scholar 

  5. Jemal A, Thun MJ, Ries LA, et al. Annual report to the nation on the status of cancer, 1975–2005, featuring trends in lung cancer, tobacco use, and tobacco control. J Natl Cancer Inst. 2008;100:1672–94.

    Google Scholar 

  6. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effect of radiotherapy after breast conserving surgery on 10-year recurrence and 15 year breast cancer death: meta-analysis of 17 randomized clinical trials. Lancet. 2011;378:1707–16.

    Google Scholar 

  7. Elfgen C, Schmid SM, Tausch CJ, Montagna G, Güth U. Radiological staging for distant metastases in breast cancer patients with confirmed local and/or Locoregional recurrence: how useful are current guideline recommendations? Ann Surg Oncol. 2019;26:3455–61. https://doi.org/10.1245/s10434-019-07629-9.

    Google Scholar 

  8. Sacchini V. Restaging patients with Locoregional relapse: is there any benefit? Commentary on “Radiological staging for distant metastases in breast cancer patients with confirmed local and/or locoregional recurrence: how useful are current guideline recommendations?” by Elfgen. Constanze et al Ann Surg Oncol. 2019;26:3415–7. https://doi.org/10.1245/s10434-019-07642-y.

    Google Scholar 

  9. Isasi CR, Moadel RM, Blaufox MD. A meta-analysis of FDG-PET for the evaluation of breast cancer recurrence and metastases. Breast Cancer Res Treat. 2005;90(2):105–12. https://doi.org/10.1007/s10549-004-3291-7.

    CAS  Google Scholar 

  10. Piva R, Ticconi F, Ceriani V, et al. Comparative diagnostic accuracy of 18F-FDG PET/CT for breast cancer recurrence. Breast Cancer (Dove Med Press). 2017;9:461–71. Published 2017 Jul 4. https://doi.org/10.2147/BCTT.S111098.

    CAS  Google Scholar 

  11. Lowery AJ, Kell MR, Glynn RW, Kerin MJ, Sweeney KJ. Locoregional recurrence after breast cancer surgery: a systematic review by receptor phenotype. Breast Cancer Res Treat. 2012;133(3):831–41. https://doi.org/10.1007/s10549-011-1891-6.

    Google Scholar 

  12. Ma J, Jiang R, Fan L, et al. Isolated locoregional recurrence patterns of breast cancer after mastectomy and adjuvant systemic therapies in the contemporary era. Oncotarget. 2015;6:36860–9. https://doi.org/10.18632/oncotarget.5365.

    Google Scholar 

  13. Salvadori B, Marubini E, Miceli R, et al. Reoperation for locally recurrent breast cancer in patients previously treated with conservative surgery. Br J Surg. 1999;86(1):84–7. https://doi.org/10.1046/j.1365-2168.1999.00961.x.

    CAS  Google Scholar 

  14. Yu C-C, Kuo W-L, Shen S-C, et al. Prognostic study for isolated local recurrence operated with salvage excision in hormone-receptor-positive patients with invasive breast cancer after primary breast surgery. Biom J. 2020;43:83–93. https://doi.org/10.1016/j.bj.2019.07.002.

    Google Scholar 

  15. Harms W, Geretschläger A, Cescato C, Buess M, Köberle D, Asadpour B. Current treatment of isolated locoregional breast cancer recurrences. Breast Care (Basel). 2015;10(4):265–71. https://doi.org/10.1159/000439151.

    Google Scholar 

  16. Belkacemi Y, Hanna NE, Besnard C, Majdoul S, Gligorov J. Local and regional breast cancer recurrences: salvage therapy options in the new era of molecular subtypes. Front Oncol. 2018;8:112. https://doi.org/10.3389/fonc.2018.00112.

    Google Scholar 

  17. Caswell-Jin JL, Plevritis SK, Tian L, et al. Change in survival in metastatic breast cancer with treatment advances: meta-analysis and systematic review. JNCI Cancer Spectr. 2018;2:pky062. https://doi.org/10.1093/jncics/pky062.

    Google Scholar 

  18. Kim H, Choi DH, Park W, et al. Prognostic factors for survivals from first relapse in breast cancer patients: analysis of deceased patients. Radiat Oncol J. 2013;31:222–7.

    Google Scholar 

  19. Leung AM, Vu HN, Nguyen KA, et al. Effects of surgical excision on survival of patients with stage IV breast cancer. J Surg Res. 2010;161:83.

    Google Scholar 

  20. Pagani O, Senkus E, Wood W, et al. International guidelines for management of metastatic breast cancer: can metastatic breast cancer be cured? J Natl Cancer Inst. 2010;102:456.

    Google Scholar 

  21. Teshome M. Role of operative Management in Stage IV breast cancer. Surg Clin North Am. 2018;98:859–68.

    Google Scholar 

  22. Badwe R, Hawaldar R, Nair N, et al. Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial. Lancet Oncol. 2015;16:1380.

    Google Scholar 

  23. King TA, Lyman JP, Gonen M, et al. Prognostic impact of 21-gene recurrence score in patients with stage IV breast cancer: TBCRC 013. J Clin Oncol. 2016;34:2359–65. https://doi.org/10.1200/JCO.2015.63.1960.

    CAS  Google Scholar 

  24. Soran A, Ozmen V, Ozbas S, et al. Randomized trial comparing resection of primary tumor with no surgery in stage IV breast cancer at presentation: protocol MF07-01. Ann Surg Oncol. 2018;25:3141.

    Google Scholar 

  25. Harris E, Barry M, Kell MR. Meta-analysis to determine if surgical resection of the primary tumour in the setting of stage IV breast cancer impacts on survival. Ann Surg Oncol. 2013;20:2828.

    Google Scholar 

  26. Cady B, Nathan NR, Michaelson JS, et al. Matched pair analyses of stage IV breast cancer with or without resection of primary breast site. Ann Surg Oncol. 2008;15:3384.

    CAS  Google Scholar 

  27. NCCN guidelines Version 3.2019 Breast Cancer.

    Google Scholar 

  28. Van Poznak C, Somerfield MR, Bast RC, et al. Use of biomarkers to guide decisions on systemic therapy for women with metastatic breast cancer: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2015;33:2695.

    Google Scholar 

  29. Cardoso F, Senkus E, Costa A, et al. 4th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 4). Ann Oncol. 2018;29:1634.

    CAS  Google Scholar 

  30. Lindström LS, Karlsson E, Wilking UM, et al. Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression. J Clin Oncol. 2012;30:2601.

    Google Scholar 

  31. Chua TC, Saxena A, Liauw W, et al. Hepatic resection for metastatic breast cancer: a systematic review. Eur J Cancer. 2011;47:2282.

    Google Scholar 

  32. Bigorie V, Morice P, Duvillard P, et al. Ovarian metastases from breast cancer: report of 29 cases. Cancer. 2010;116:799.

    Google Scholar 

  33. Li W, Wang H, Wang J, et al. Ovarian metastases resection from extragenital primary sites: outcome and prognostic factor analysis of 147 patients. BMC Cancer. 2012;12:278.

    Google Scholar 

  34. Noble J, Sirohi B, Ashley S, et al. Sternal/para-sternal resection for parasternal local recurrence in breast cancer. Breast. 2010;19:350.

    Google Scholar 

  35. Selzner M, Morse MA, Vredenburgh JJ, et al. Liver metastases from breast cancer: long-term survival after curative resection. Surgery. 2000;127:383.

    CAS  Google Scholar 

  36. Maksan SM, Lehnert T, Bastert G, Herfarth C. Curative liver resection for metastatic breast cancer. Eur J Surg Oncol. 2000;26:209.

    CAS  Google Scholar 

  37. Sadot E, Lee SY, Sofocleous CT, et al. Hepatic resection or ablation for isolated breast cancer liver metastasis: a case-control study with comparison to medically treated patients. Ann Surg. 2016;264:147.

    Google Scholar 

  38. Pawlik TM, Izzo F, Cohen DS, et al. Combined resection and radiofrequency ablation for advanced hepatic malignancies: results in 172 patients. Ann Surg Oncol. 2003;10:1059.

    Google Scholar 

  39. Bortolotto C, Macchi S, Veronese L, et al. Radiofrequency ablation of metastatic lesions from breast cancer. J Ultrasound. 2012;15:199.

    CAS  Google Scholar 

  40. Planchard D, Soria JC, Michiels S, et al. Uncertain benefit from surgery in patients with lung metastases from breast carcinoma. Cancer. 2004;100:28.

    Google Scholar 

  41. Friedel G, Pastorino U, Ginsberg RJ, et al. Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases. Eur J Cardiothorac Surg. 2002;22:335.

    Google Scholar 

  42. Yoshimoto M, Tada K, Nishimura S, et al. Favourable long-term results after surgical removal of lung metastases of breast cancer. Breast Cancer Res Treat. 2008;110:485.

    Google Scholar 

  43. Meimarakis G, Rüttinger D, Stemmler J, et al. Prolonged overall survival after pulmonary metastasectomy in patients with breast cancer. Ann Thorac Surg. 2013;95:1170.

    Google Scholar 

  44. Briasoulis E, Karavasilis V, Kostadima L, et al. Metastatic breast carcinoma confined to bone: portrait of a clinical entity. Cancer. 2004;101:1524.

    Google Scholar 

  45. Alvarado-Cabrero I, Rodríguez-Gómez A, Castelan-Pedraza J, Valencia-Cedillo R. Metastatic ovarian tumors: a clinicopathologic study of 150 cases. Anal Quant Cytopathol Histpathol. 2013;35:241.

    Google Scholar 

  46. Quan ML, Fey J, Eitan R, et al. Role of laparoscopy in the evaluation of the adnexa in patients with stage IV breast cancer. Gynecol Oncol. 2004;92:327.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Professor and Head, Department of Surgical Oncology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India

    Sunil Saini MS

  2. Associate Professor, Department of Surgical Oncology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India

    Manisa Pattanayak MS

  3. Assistant Professor, Department of Surgical Oncology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India

    Anshika Arora MS

Authors
  1. Sunil Saini MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Manisa Pattanayak MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anshika Arora MS
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sunil Saini MS .

Editor information

Editors and Affiliations

  1. Department of Radiotherapy, MM IMSR, Mullana, Ambala, Haryana, Chandigarh, India

    Suresh Chander Sharma

  2. Department of General Surgery, Seven Hills Hospital, Visakhapatnam, Andhra Pradesh, India

    Alok Mazumdar

  3. Department of General Surgery, Government Medical College and Hospital, Chandigarh, Chandigarh, India

    Robin Kaushik

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Saini, S., Pattanayak, M., Arora, A. (2022). Recurrent Breast Cancer (Local and Metastatic): Surgical Aspects. In: Sharma, S.C., Mazumdar, A., Kaushik, R. (eds) Breast Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-16-4546-4_17

Download citation

  • DOI: https://doi.org/10.1007/978-981-16-4546-4_17

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-4545-7

  • Online ISBN: 978-981-16-4546-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation