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Antimicrobial Peptides as Effective Agents Against Drug-Resistant Pathogens

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Antimicrobial Resistance

Abstract

The rising incidence of antimicrobial resistance continues to project a global healthcare concern. The spread of drug-resistant pathogens and indiscriminate use of the existing antibiotics has a profound effect on the economy of developing and under-developing countries. However, the drying pipeline of antibiotic arsenals and little progress in this direction necessitate the discovery and characterization of novel antimicrobials from natural sources. Antimicrobial peptides (AMPs) are gaining momentum as antimicrobial therapeutics with potent efficacy to tackle rising drug-resistant bacterial strains. The natural and synthetic AMPs as novel antimicrobials highlight remarkable therapeutic potential via diverse mechanism of action. Recent advances in antimicrobial research have improved our knowledge on the structure, properties, and function of AMPs; however, there is still a long way ahead for complete exploitation of these therapeutic candidates. With an overview on the emerging popularity of AMPs in countering diverse infectious diseases and drug-resistant pathogens, the chapter provides a detailed insight on the history and development of AMPs and its production in plant-based expression systems. The contribution of combinational chemistry co-integrated with computational biology in AMP research and development, projected bottlenecks, and prospects of success are further discussed.

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The authors acknowledge their respective institutions for encouragement and support.

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Authors and Affiliations

  1. Molecular Metabolic Engineering Lab, Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Republic of Korea

    Pragya Tiwari

  2. Department of Biotechnology, Invertis University, Bareilly, Uttar Pradesh, India

    Yashdeep Srivastava

  3. Department of Biotechnology, Modern College of Arts, Science and Commerce, Savitribai Phule Pune University, Pune, India

    Vinay Kumar

  4. Department of Environmental Science, Savitribai Phule Pune University, Pune, India

    Vinay Kumar

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  1. Department of Biotechnology, Savitribai Phule Pune University, Modern College of Arts, Science and Commerce, Ganeshkhind, Maharashtra, India

    Vinay Kumar

  2. Department of Botany, Savitribai Phule Pune University, Ramkrishna More Arts, Commerce and Science College, Pune, Maharashtra, India

    Varsha Shriram

  3. Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan, India

    Atish Paul

  4. School of Biomedical Sciences, Mahatma Gandhi Mission Institute of Heal, Navi Mumbai, Maharashtra, India

    Mansee Thakur

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Tiwari, P., Srivastava, Y., Kumar, V. (2022). Antimicrobial Peptides as Effective Agents Against Drug-Resistant Pathogens. In: Kumar, V., Shriram, V., Paul, A., Thakur, M. (eds) Antimicrobial Resistance. Springer, Singapore. https://doi.org/10.1007/978-981-16-3120-7_11

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