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Alteration of Endoplasmic Reticulum Stress

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Coal-burning Type of Endemic Fluorosis

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Abstract

The endoplasmic reticulum (ER) stress is induced by protein misfolding and nutritional deprivation in many eukaryotic cells. Meantime, an imbalance between protein synthesis and folding capacity of ER also caused the unfolded protein response (UPR). The UPR included three different protein family signals: double-stranded RNA-activated protein kinase like ER kinase, inositol-requiring kinase 1, and activating transcription factor 6, all of which are triggered during ER stress. Malfunction of UPR is induced by aging, genetic mutations, or environmental factors and results in various diseases, especially metabolic disease. The main adverse effects of chronic fluorosis are skeletal, dental, or enamel damages. The soft tissue lesions of fluorosis have been observed and discussed. The underlying mechanisms that mediated these effects remained poorly understand. This section is to review the role of ER stress in mechanism that overdosal fluoride exposure caused body lesion.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin, People’s Republic of China

    Hui Xu, Feng-Yang Guo & Zhong-Yuan Zhang

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  1. Hui Xu
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  2. Feng-Yang Guo
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  3. Zhong-Yuan Zhang
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Correspondence to Hui Xu .

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Editors and Affiliations

  1. Department of Pathology, Affiliated Hospital and Key Laboratory of Endemic and Ethnic Diseases of the Ministry of Education, Guizhou Medical University, Guiyang, China

    Zhi-Zhong Guan

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Xu, H., Guo, FY., Zhang, ZY. (2021). Alteration of Endoplasmic Reticulum Stress. In: Guan, ZZ. (eds) Coal-burning Type of Endemic Fluorosis. Springer, Singapore. https://doi.org/10.1007/978-981-16-1498-9_16

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