Abstract
Oxidative stress is a physiological phenomenon that provides favorable outcomes such as in inflammation processes. It has also a harmful side that when the level of reactive oxygen species produced is higher than the capacity of the cell to neutralize them, this imbalance can develop into a precursor of some pathological conditions or enhance already present conditions. On the other hand, scientists have been exploring the oxidative stress system for decades and learned how to harness this system in therapy. The most popular approach is the use of natural and dietary antioxidant to target oxidative stress and induce therapy. However, other than the natural sources, scientists seek many synthetic and novel molecules such as peptide hybrids, polymers, and nanoparticles, which contain an inherent antioxidant activity in their structures. In this chapter, we tried to focus on the novel experimental therapeutic approaches used in pathology and chemotherapy. We hope the colleagues will be able to garner an interest to such approaches and further harness the oxidative stress in their research using these new tools to enhance biomedicine and therapeutics.
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References
Bhandarkar SS et al (2009) Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. J Clin Invest 119:2359–2365. https://doi.org/10.1172/JCI33877
Bonetta R (2018) Potential therapeutic applications of MnSODs and SOD-Mimetics. Chemistry (Weinheim an der Bergstrasse, Germany) 24:5032–5041. https://doi.org/10.1002/chem.201704561
Bostwick DG et al (2000) Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer. Cancer 89:123–134. https://doi.org/10.1002/1097-0142(20000701)89:1<123::aid-cncr17>3.3.co;2-0
Campana F et al (2004) Topical superoxide dismutase reduces post-irradiation breast cancer fibrosis. J Cell Mol Med 8:109–116. https://doi.org/10.1111/j.1582-4934.2004.tb00265.x
Chen HM, Muramoto K, Yamauchi F, Nokihara K (1996) Antioxidant activity of designed peptides based on the antioxidative peptide isolated from digests of a soybean protein. J Agric Food Chem 44:2619–2623. https://doi.org/10.1021/jf950833m
Chen GT, Zhao L, Zhao LY, Cong T, Bao SF (2007) In vitro study on antioxidant activities of peanut protein hydrolysate. J Sci Food Agric 87:357–362. https://doi.org/10.1002/jsfa.2744
Clichici S et al (2010) The dynamics of reactive oxygen species in photodynamic therapy with tetra sulfophenyl-porphyrin. Acta Physiol Hung 97:41–51. https://doi.org/10.1556/APhysiol.97.2010.1.5
Conklin KA (2000) Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects. Nutr Cancer 37:1–18. https://doi.org/10.1207/S15327914NC3701_1
Crosas-Molist E et al (2014) The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression. Free Radic Biol Med 69:338–347. https://doi.org/10.1016/j.freeradbiomed.2014.01.040
D’Archivio M, Filesi C, Vari R, Scazzocchio B, Masella R (2010) Bioavailability of the polyphenols: status and controversies. Int J Mol Sci 11:1321–1342. https://doi.org/10.3390/ijms11041321
Das S, Dowding JM, Klump KE, McGinnis JF, Self W, Seal S (2013) Cerium oxide nanoparticles: applications and prospects in nanomedicine. Nanomedicine (Lond) 8:1483–1508. https://doi.org/10.2217/nnm.13.133
Dosoki H et al (2017) Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis. Exp Dermatol 26:73–81. https://doi.org/10.1111/exd.13180
Egea J et al (2017) European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol 13:94–162. https://doi.org/10.1016/j.redox.2017.05.007
Frackowiak D, Planner A, Waszkowiak A, Boguta A, Ion R-M, Wiktorowicz K (2001) Yield of intersystem (singlet–triplet) crossing in phthalocyanines evaluated on the basis of a time in resolved photothermal method. J Photochem Photobiol A Chem 141:101–108. https://doi.org/10.1016/s1010-6030(01)00438-5
Gille L, Nohl H (1997) Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity. Free Radic Biol Med 23:775–782. https://doi.org/10.1016/s0891-5849(97)00025-7
Giri S et al (2013) Nanoceria: a rare-earth nanoparticle as a novel anti-angiogenic therapeutic agent in ovarian cancer. PLoS One 8:e54578. https://doi.org/10.1371/journal.pone.0054578
Grebowski J, Krokosz A (2010) Fullerenes in radiobiology. Postepy Biochem 56:456–462
Hernandez-Ledesma B, Davalos A, Bartolome B, Amigo L (2005) Preparation of antioxidant enzymatic hydrolysates from alpha-lactalbumin and beta-lactoglobulin. Identification of active peptides by HPLC-MS/MS. J Agric Food Chem 53:588–593. https://doi.org/10.1021/jf048626m
Hijaz M et al (2016) Folic acid tagged nanoceria as a novel therapeutic agent in ovarian cancer. BMC Cancer 16:220. https://doi.org/10.1186/s12885-016-2206-4
Hong SY et al (2005) Effect of high-dose intravenous N-acetylcysteine on the concentration of plasma sulfur-containing amino acids. Korean J Intern Med 20:217–223. https://doi.org/10.3904/kjim.2005.20.3.217
Jia PP, Dai CY, Cao PH, Sun D, Ouyang RZ, Miao YQ (2020) The role of reactive oxygen species in tumor treatment. Rsc Advances 10:7740–7750. https://doi.org/10.1039/c9ra10539e
Katsumi H et al (2014) Pharmacokinetics and preventive effects of platinum nanoparticles as reactive oxygen species scavengers on hepatic ischemia/reperfusion injury in mice. Metallomics 6:1050–1056. https://doi.org/10.1039/c4mt00018h
Kondo S, Toyokuni S, Iwasa Y, Tanaka T, Onodera H, Hiai H, Imamura M (1999) Persistent oxidative stress in human colorectal carcinoma, but not in adenoma. Free Radical Biol Med 27:401–410. https://doi.org/10.1016/s0891-5849(99)00087-8
Lee JA et al (2014) Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats. Int J Nanomedicine 9(Suppl 2):251–260. https://doi.org/10.2147/IJN.S57939
Li XX, Han LJ, Chen LJ (2008) In vitro antioxidant activity of protein hydrolysates prepared from corn gluten meal. J Sci Food Agric 88:1660–1666. https://doi.org/10.1002/jsfa.3264
Martinez FJ, de Andrade JA, Anstrom KJ, King TE Jr, Raghu G (2014) Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis. New England J Med 370:2093–2101. https://doi.org/10.1056/NEJMoa1401739
Mehta G, Singh V (2002) Hybrid systems through natural product leads: an approach towards new molecular entities. Chem Soc Rev 31:324–334. https://doi.org/10.1039/b204748a
Meister A (1994) Glutathione, ascorbate, and cellular protection. Cancer Res 54:1969s–1975s
Morry J et al (2015) Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis. Biomaterials 66:41–52. https://doi.org/10.1016/j.biomaterials.2015.07.005
Morry J, Ngamcherdtrakul W, Yantasee W (2017) Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles. Redox Biol 11:240–253. https://doi.org/10.1016/j.redox.2016.12.011
Nagasawa T, Yonekura T, Nishizawa N, Kitts DD (2001) In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine. Mol Cell Biochem 225:29–34. https://doi.org/10.1023/a:1012256521840
Ngamcherdtrakul W et al (2015) Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted SiRNA Delivery to HER2+ Breast Cancer. Adv Funct Mater 25:2646–2659. https://doi.org/10.1002/adfm.201404629
Niu Y, Epperly MW, Shen H, Smith T, Wang H, Greenberger JS (2008) Intraesophageal MnSOD-plasmid liposome enhances engraftment and self-renewal of bone marrow derived progenitors of esophageal squamous epithelium. Gene Ther 15:347–356. https://doi.org/10.1038/sj.gt.3303089
Nohl H (1987) Demonstration of the existence of an organo-specific NADH dehydrogenase in heart mitochondria. Eur J Biochem 169:585–591. https://doi.org/10.1111/j.1432-1033.1987.tb13649.x
Oberley TD, Zhong W, Szweda LI, Oberley LW (2000) Localization of antioxidant enzymes and oxidative damage products in normal and malignant prostate epithelium. Prostate 44:144–155. https://doi.org/10.1002/1097-0045(20000701)44:2<144::aid-pros7>3.0.co;2-g
Okamoto K et al (1994) Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma. Int J Cancer 58:825–829. https://doi.org/10.1002/ijc.2910580613
Phillips E et al (2014) Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe. Sci Transl Med 6:260ra149. https://doi.org/10.1126/scitranslmed.3009524
Prylutska S, Grynyuk I, Matyshevska O, Prylutskyy Y, Evstigneev M, Scharff P, Ritter U (2014) C60 fullerene as synergistic agent in tumor-inhibitory Doxorubicin treatment. Drugs R D 14:333–340. https://doi.org/10.1007/s40268-014-0074-4
Rajapakse N, Mendis E, Jung WK, Je JY, Kim SK (2005) Purification of a radical scavenging peptide from fermented mussel sauce and its antioxidant properties. Food Res Int 38:175–182. https://doi.org/10.1016/j.foodres.2004.10.002
Saito K, Jin DH, Ogawa T, Muramoto K, Hatakeyama E, Yasuhara T, Nokihara K (2003) Antioxidative properties of tripeptide libraries prepared by the combinatorial chemistry. J Agric Food Chem 51:3668–3674. https://doi.org/10.1021/jf021191n
Shacter E, Williams JA, Hinson RM, Senturker S, Lee YJ (2000) Oxidative stress interferes with cancer chemotherapy: inhibition of lymphoma cell apoptosis and phagocytosis. Blood 96:307–313
Shah MH, Liu GS, Thompson EW, Dusting GJ, Peshavariya HM (2015) Differential effects of superoxide dismutase and superoxide dismutase/catalase mimetics on human breast cancer cells. Breast Cancer Res Treat 150:523–534. https://doi.org/10.1007/s10549-015-3329-z
Shimada K, Fujii T, Anai S, Fujimoto K, Konishi N (2011) ROS generation via NOX4 and its utility in the cytological diagnosis of urothelial carcinoma of the urinary bladder. BMC Urol 11:22. https://doi.org/10.1186/1471-2490-11-22
Siu KS et al (2014) Non-covalently functionalized single-walled carbon nanotube for topical siRNA delivery into melanoma. Biomaterials 35:3435–3442. https://doi.org/10.1016/j.biomaterials.2013.12.079
Slowing II, Trewyn BG, Giri S, Lin VSY (2007) Mesoporous silica nanoparticles for drug delivery and biosensing applications. Adv Func Mater 17:1225–1236. https://doi.org/10.1002/adfm.200601191
Sosa V, Moline T, Somoza R, Paciucci R, Kondoh H, LL ME (2013) Oxidative stress and cancer: an overview. Ageing Res Rev 12:376–390. https://doi.org/10.1016/j.arr.2012.10.004
Tarhini AA et al (2011) A phase I study of concurrent chemotherapy (paclitaxel and carboplatin) and thoracic radiotherapy with swallowed manganese superoxide dismutase plasmid liposome protection in patients with locally advanced stage III non-small-cell lung cancer. Hum Gene Ther 22:336–342. https://doi.org/10.1089/hum.2010.078
van Lith R, Ameer GA (2016) Antioxidant polymers as biomaterial. Elsevier. https://doi.org/10.1016/b978-0-12-803269-5.00010-3
Wang W, de Mejia EG (2005) A new frontier in soy bioactive peptides that may prevent age-related chronic diseases. Comp Rev Food Sci Food Saf 4:63–78. https://doi.org/10.1111/j.1541-4337.2005.tb00075.x
Wind S et al (2010) Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. Br J Pharmacol 161:885–898. https://doi.org/10.1111/j.1476-5381.2010.00920.x
Xu Y et al (1999) Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells. Oncogene 18:93–102. https://doi.org/10.1038/sj.onc.1202265
Xu JY et al (2010) Protective effects of fullerenol on carbon tetrachloride-induced acute hepatotoxicity and nephrotoxicity in rats. Carbon 48:1388–1396. https://doi.org/10.1016/j.carbon.2009.12.029
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Moulahoum, H., Ghorbanizamani, F., Timur, S., Zihnioglu, F. (2021). Beyond Natural Antioxidants in Cancer Therapy: Novel Synthetic Approaches in Harnessing Oxidative Stress. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_43-1
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