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Cancer Stem Cells: Reactive Oxygen Species-Induced Drug Resistance in Cancer

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

At present, there are several advancements in the field of cancer treatment that promise to increase the lifespan of a cancer patient. However, cancer recurrence and drug resistance are the challenges still faced in the field of cancer treatment. The normal production of cellular reactive oxygen species (ROS) plays a pivotal role in maintaining the cell quiescence and metabolism of stem cells. Overproduction of ROS leads to cell proliferation, differentiation, and apoptosis in a dose-exposure manner. Cancer stem cells (CSCs) could self-renew and protect themselves from exposure to toxic chemicals and free radicals. ROS are induced by several signaling molecules, such as growth factors, Wnt, Notch, and Hedgehog pathways. Recent studies have also suggested that microRNAs (miRNAs) induce ROS production and activate various signaling cascades to induce cell proliferation in cancer cells. In addition, chemotherapy activates the overexpression of cancer miRNAs in tumor cells, which induces the epithelial to mesenchymal transition that leads to therapeutic resistance. In most of the malignant conditions, miRNAs enhance the expression of signaling pathways in CSCs and activate cell proliferation. In this review, we provide an update to ROS-mediated therapeutic resistance in the signaling pathways of CSCs.

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Author Contributions

P.R. and S.J. wrote the manuscript. D.G. and K.P. edited the manuscript. All authors contributed to the article and approved the submitted version.

Funding

This study was supported by Department of Science and Technology (DST) Science Engineering Research Board (SERB), Government of India grant number EEQ/2017/000567 to KP.

Author information

Authors and Affiliations

  1. Cancer Science Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Chengalpattu, India

    Praveen Rajendran, Dhanavathy Gnanasampanthapandian & Kanagaraj Palaniyandi

  2. Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India

    Selvaraj Jayaraman

  3. Interdisciplinary Institute of Indian System of Medicine, SRM Institute of Science and Technology, Chengalpattu, India

    Ganesh Munuswamy-Ramanujam & Rajappan Chandra Satish Kumar

  4. Department of Surgery, SRM Medical College Hospital and Research Center, Kancheepuram, India

    Balamurugan Ramachandran

  5. Department of Surgery, Comprehensive Transplant Center, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

    Yuvaraj Sambandam

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  1. Praveen Rajendran
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  2. Selvaraj Jayaraman
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  3. Ganesh Munuswamy-Ramanujam
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  4. Rajappan Chandra Satish Kumar
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  5. Balamurugan Ramachandran
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  6. Yuvaraj Sambandam
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  7. Dhanavathy Gnanasampanthapandian
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  8. Kanagaraj Palaniyandi
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Editor information

Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Cellular Stress and Immune Response Laboratory, Centre for Cancer Biology, University of South Australia, Adelaide, South Australia, Australia

    Nirmal Robinson

  2. Department of Morphofunctional Sciences, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

    Cornelia Amalinei

  3. Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India

    Amitava Das

  4. Biological Sciences, Academy of Scientific and Innovative Research, Ghaziabad,, UP, India

    Amitava Das

  5. Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chennai, Tamil Nadu, India

    Surajit Pathak

  6. Stem Cell Facility, DBT-Centre of Excellence for Stem Cell Research, All India Institute of Medical Sciences, New Delhi, India

    Sujata Mohanty

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Rajendran, P. et al. (2022). Cancer Stem Cells: Reactive Oxygen Species-Induced Drug Resistance in Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_217-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_217-1

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  • Print ISBN: 978-981-16-1247-3

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