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Surgical Models of Laboratory Animals

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Essentials of Laboratory Animal Science: Principles and Practices

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Abstract

Animal models play a pivotal role in biomedical research. Surgical rodent models are widely used in the preclinical drug discovery process. A well-planned surgery with aseptic techniques including intraoperative as well as postoperative care is necessitated for the successful surgical outcomes and survivability of animals. Consideration should be given for the pre-emptive and postoperative analgesia of choice with appropriate dosage regimen to prevent pain and distress in the animals. Furthermore, good management practices, minimal handling, socialization, and environmental enrichment provide comfort by reducing the stress in the animals that underwent surgery.

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Abbreviations

BUN:

Blood urea nitrogen

CCA:

Common carotid artery

CCI:

Chronic constriction injury

ECA:

External carotid artery

ICA:

Internal carotid artery

PDS:

Polydioxanone

PE:

Polyethylene

PTFE:

Polytetrafluoroethylene

PVDF:

Polyvinylidene fluoride

VCC:

Vena cava caudalis

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Authors and Affiliations

  1. Syngene International Limited, Bangalore, Karnataka, India

    R. K. Shakthi Devan

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  1. R. K. Shakthi Devan
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Editors and Affiliations

  1. Experimental Animal Facility, National Institute of Immunology, New Delhi, Delhi, India

    P. Nagarajan

  2. Central Animal Facility, Indian Institute of Science, Bangalore, Karnataka, India

    Ramachandra Gudde

  3. Veterinary Pharmacology and Toxicology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu, India

    Ramesh Srinivasan

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Devan, R.K.S. (2021). Surgical Models of Laboratory Animals. In: Nagarajan, P., Gudde, R., Srinivasan, R. (eds) Essentials of Laboratory Animal Science: Principles and Practices. Springer, Singapore. https://doi.org/10.1007/978-981-16-0987-9_32

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