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Stem Cells in the Treatment of Diabetic Foot Ulcers

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Diabetic Foot Ulcer

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Abstract

Diabetes mellitus is the most common chronic disease that can lead to many clinical complications including vision, cardiac, and vascular disorders. Among vascular disorders, Diabetic foot ulcer (DFU) is a severe, fatal, serious and devastating complication and remained major economic consequences for the patients and country and is now a global public health issue. The prevalence of Diabetic foot ulcer in Western countries is 4–10% whereas the prevalence of Diabetic foot ulcer in the world is 15%. It has been reported that the healing rate of DFU is only 10–60% of patients after the first 3 months however the recurrence rate is 40%, 60%, and 71% after 1, 2, and 3 years, respectively. Limited treatment options are available for DFU patients. Stem cell therapy holds a great promise for treating Diabetic foot ulcer (DFU) and recently emerged as a new interventional strategy and appears to be cost-effective safe and effective in both preclinical and clinical trials. The most important characteristic for the successful utilization of mesenchymal stem cell treatments is the conducting of rapid and robust randomized controlled clinical trials. Diabetic foot ulcer remains the most important clinical challenge in the current medical practice and stem cell therapy may be an effective treatment for Diabetic foot ulcers. It is concluded that stem cell therapy is a potential, advanced, and effective treatment for Diabetic foot ulcers and is utilized as an alternative to amputation for T2D patients for revascularization. This therapy is utilizing tissue engineering as well as regenerative medicine.

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Authors and Affiliations

  1. Prince Fahd Bin Sultan Research Chair, Division of Molecular Biology, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Kingdom of Saudi Arabia

    Rashid Mir

  2. Department of Biochemistry, Faculty of Sciences, University of Tabuk, Tabuk, Kingdom of Saudi Arabia

    Imadeldin Elfaki

  3. Centre of Research for Development, University of Kashmir, Srinagar, Kashmir, India

    Ajaz Ahmad Waza

  4. Prince Fahd Bin Sultan Research Chair, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Kingdom of Saudi Arabia

    Faisel M. AbuDuhier

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  1. Rashid Mir
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  2. Imadeldin Elfaki
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  4. Faisel M. AbuDuhier
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Editors and Affiliations

  1. Department of Medical Microbiology, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia

    Mohammad Zubair

  2. Consultant, Diabetes & Endocrinology, Superspeciality Center, Aligarh, Uttar Pradesh, India

    Jamal Ahmad

  3. Ex-Chairperson-Department of Microbiology, Former Dean-Faculty of Medicine, J N Medical College & Hospital Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    Abida Malik

  4. Research Associate, Bioanalytical Department, AXIS Clinicals, Hyderabad, Telangana, India

    Mallikarjuna Rao Talluri

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Mir, R., Elfaki, I., Waza, A.A., AbuDuhier, F.M. (2021). Stem Cells in the Treatment of Diabetic Foot Ulcers. In: Zubair, M., Ahmad, J., Malik, A., Talluri, M.R. (eds) Diabetic Foot Ulcer. Springer, Singapore. https://doi.org/10.1007/978-981-15-7639-3_16

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