Skip to main content

Neural Network Ensemble-Based Prediction System for Chemotherapy Pathological Response: A Case Study

  • Conference paper
  • First Online:
Advances in Communication and Computational Technology (ICACCT 2019)

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 668))

  • 1763 Accesses

Abstract

During the diagnosis of breast cancer, neoadjuvant chemotherapy is supplied intravenously. Physicians recommend chemotherapy before surgery to reduce the invasive tumor’s large size. This research work suggests a model for Neural Network Ensemble Machine Learning, Implementation of a series of machine learning algorithms to create an enhanced and efficient predictable solution patients ‘maximum pathological response after Neoadjuvant Chemotherapy. The quality of the neural network ensemble framework for machine learning is measured using multicriteria technique of decision making known as simple weighted additive (WSAW). The performance score for WSAW is calculated by taking into account ten measurements, namely accuracy, mean absolute error, root mean square error, TP rate, FP rate, accuracy, recall, F-measure, MCC, and ROC. The results are verified using the technique of cross-validation K-fold to achieve 97.20% accuracy. The findings are quite positive when the execution of the proposed system is coupled with the output of state-of-the-art classificators, for example, Bayes Net, Naïve Bayes, logistic, multilayer perceptron, SMO, voted perceptron, etc. With the increasing trend of artificial intelligence applications in cancer research, machine learning has a great future in forecasting and decision making.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Asano Y et al (2017) Prediction of survival after neoadjuvant chemotherapy for breast cancer by evaluation of tumor infiltrating lymphocytes and residual cancer burden. BMC Cancer 17(1):88

    Article  Google Scholar 

  2. Borchert et al (1997) Elevated levels of prostate-specific anti- gen in serum of women with fibroadenomas and breast cysts. J Natl Cancer Inst 89(8):587–588

    Article  Google Scholar 

  3. Haffty B et al (2011) Meta-analysis confirms achieving pathological complete response after neoadjuvant chemotherapy predicts favourable prognosis for breast cancer patients. Eur J Cancer 47(14):2084–2090

    Article  Google Scholar 

  4. Asri H et al (2016) Using machine learning algorithms for breast cancer risk prediction and diagnosis. Procedia Comput Sci 83:1064–1069

    Article  Google Scholar 

  5. Tahmassebi A et al (2019) Impact of machine learning with multiparametric magnetic resonance imaging of the breast for early prediction of response to neoadjuvant chemotherapy and survival outcomes in breast cancer patients. Invest Radiol 54(2):110–117

    Article  Google Scholar 

  6. Bibault JE et al (2016) Big data and machine learning in radiation oncology: state of the art and future prospects. Cancer Lett 382(1):110–117

    Article  Google Scholar 

  7. Aslan MF et al (2018) Breast cancer diagnosis by different machine learning methods using blood analysis data. Int J Intell Syst Appl Eng 6(4):289–293

    Article  Google Scholar 

  8. Huang CL et al (2008) Prediction model building and feature selection with support vector machines in breast cancer diagnosis. Expert Syst Appl 34(1):578–587

    Article  Google Scholar 

  9. Yang P et al (2010) A review of ensemble methods in bioinformatics. Curr Bioinform 5(4):296–308

    Article  Google Scholar 

  10. Kourou K et al (2015) Machine learning applications in cancer prognosis and prediction. Comput Struct Biotechnol J 13:8–17

    Article  Google Scholar 

  11. Cain EH et al (2019) Multivariate machine learning models for prediction of pathologic response to neoadjuvant therapy in breast cancer using MRI features: a study using an independent validation set. Breast Cancer Res Treat 173(2):455–463

    Article  Google Scholar 

  12. Bashiri A et al (2017) Improving the prediction of survival in cancer patients by using machine learning techniques: Experience of gene expression data: A narrative review. Iran J Publ Health 46(2):165

    MathSciNet  Google Scholar 

  13. Wang H et al (2018) A support vector machine-based ensemble algorithm for breast cancer diagnosis. Eur J Oper Res 267(2):687–699

    Article  MathSciNet  MATH  Google Scholar 

  14. Pearl J (2000) Causality: Models, reasoning, and inference. Cambridge University Press. ISBN 0-521-77362-8. OCLC 42291253

    Google Scholar 

  15. McCallum A et al (1998, July) A comparison of event models for naive bayes text classification. In: AAAI-98 workshop on learning for text categorization, vol 752, No. 1, pp. 41–48)

    Google Scholar 

  16. Syarif A et al (2002) Study on multi-stage logistic chain network: a spanning tree based genetic algorithm approach. Comput Ind Eng 43(1–2):299–314

    Article  Google Scholar 

  17. Orhan U et al (2011) EEG signals classification using the K-means clustering and a multilayer perceptron neural network model. Expert Syst Appl 38(10):13475–13481

    Article  Google Scholar 

  18. Cortes C et al (1995) Support-vector networks. Mach Learn 20(3):273–297. https://doi.org/10.1007/BF00994018

  19. Huang YM et al (2006) Evaluation of neural networks and data mining methods on a credit assessment task for class imbalance problem. Nonlinear Anal Real World Appl 7(4):720–747

    Article  MathSciNet  MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nishtha Hooda .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Singapore Pte Ltd.

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Bhardwaj, R., Hooda, N. (2021). Neural Network Ensemble-Based Prediction System for Chemotherapy Pathological Response: A Case Study. In: Hura, G.S., Singh, A.K., Siong Hoe, L. (eds) Advances in Communication and Computational Technology. ICACCT 2019. Lecture Notes in Electrical Engineering, vol 668. Springer, Singapore. https://doi.org/10.1007/978-981-15-5341-7_30

Download citation

  • DOI: https://doi.org/10.1007/978-981-15-5341-7_30

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-5340-0

  • Online ISBN: 978-981-15-5341-7

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics