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Pesticide and Immunotoxicology

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Allergy and Immunotoxicology in Occupational Health - The Next Step

Abstract

Several types of pesticides such as organophosphates, phenoxyacetic acid, and carbamate have a high risk of affecting human immune system, causing immune suppression, allergies, and autoimmune diseases. However, immunotoxicology of pesticides has not been characterized well so far. Therefore, this chapter will address the immunotoxic response including immunosuppression, hypersensitivity, and autoimmune diseases to environmental chemicals such as pesticide, herbicide, and fungicide. In addition, current detection method for immunotoxic substances is not sensitive and optimized enough to look for the events associated with pesticide exposure, whereas general toxicity, reproductive toxicity, neurotoxicity, and genotoxicity are basically well detected throughout the international guidelines issued by Organization for Economic Cooperation and Development (OECD) or United States Environmental Protection Agency (EPA). Recently, our group has developed several immunotoxicology tests particularly for immunosuppression and respiratory sensitization both in vivo and in vitro. This chapter will also focus on newly developed testing method to detect the immunotoxic event associated with pesticide exposure.

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Authors and Affiliations

  1. Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan

    Tomoki Fukuyama

  2. The Institute of Environmental Toxicology, Ibaraki, Japan

    Risako Tajiki-Nishino

Authors
  1. Tomoki Fukuyama
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  2. Risako Tajiki-Nishino
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Correspondence to Tomoki Fukuyama .

Editor information

Editors and Affiliations

  1. Department of Hygiene, Kawasaki Medical School, Kurashiki, Okayama, Japan

    Takemi Otsuki

  2. Department of Medicine and Aging Science (DMSI), University G. d’Annunzio of Chieti-Pescara, Chieti, Italy

    Mario Di Gioacchino

  3. Department of Medicine and Aging Science (DMSI), University G. d’Annunzio of Chieti-Pescara, Chieti, Italy

    Claudia Petrarca

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Fukuyama, T., Tajiki-Nishino, R. (2020). Pesticide and Immunotoxicology. In: Otsuki, T., Di Gioacchino, M., Petrarca, C. (eds) Allergy and Immunotoxicology in Occupational Health - The Next Step. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-15-4735-5_12

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  • DOI: https://doi.org/10.1007/978-981-15-4735-5_12

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