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System Biology and Network Analysis Approaches on Oxidative Stress in Cancer

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

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Abstract

Oxidative stress refers to the pathophysiological condition when production of reactive oxygen species (ROS) saturates the intrinsic antioxidant defense mechanism. ROS have been shown to modulate diverse physiological processes including cellular signaling by acting as second messengers, hypoxic response pathways, inflammation, and immune response in mammalian cells. However, defects in antioxidant defense machinery contribute to elevated levels of ROS resulting in cytotoxicity and impaired cellular functions. In mitochondria, ROS are produced as an inescapable byproduct of oxidative phosphorylation, and hypoxia also promotes amplification of cellular levels of ROS. Hypoxia and oxidative stress-induced generation of ROS contribute to each step of carcinogenesis, starting from tumor formation to malignant transformation. This transformation involves dysregulation of an enormous number of genes and proteins, involved in various pathways including the conventional hypoxia-inducible factor (HIF) pathway. Understanding the interconnectivity between signaling and metabolic pathways is indispensable for early disease detection and therapeutics to develop. System biology aids in this process by analyzing disease dynamics as an integrated system of genes, networks, and pathways to gain important biological insights. Network-based comprehensive analysis integrates multifaceted high throughput data to identify novel cancer biomarkers. Integration of network and pathway analysis can effectively detect molecules and pathways that get perturbed during tumorigenesis. Eventually, dynamic analysis of biological networks using systems biology approaches may provide useful information to gain better understanding of a multifactorial disease like cancer.

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Authors and Affiliations

  1. Structural Biology and Bioinformatics Division, Indian Institute of Chemical Biology, Kolkata, India

    Sarpita Bose, Krishna Kumar & Saikat Chakrabarti

Authors
  1. Sarpita Bose
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  2. Krishna Kumar
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  3. Saikat Chakrabarti
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Corresponding author

Correspondence to Saikat Chakrabarti .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysic, University of Kalyani Department of Biochemistry and Biophysic, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Dept of Veterinary Pathobiology, University of Missouri, College Vet, Columbia, MO, USA

    Bimal K Ray

  3. Saroj Gupta Cancer Centre & Research Ins, Kolkata, India

    Sushanta Roychowdhury

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Bose, S., Kumar, K., Chakrabarti, S. (2021). System Biology and Network Analysis Approaches on Oxidative Stress in Cancer. In: Chakraborti, S., Ray, B.K., Roychowdhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_158-1

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  • DOI: https://doi.org/10.1007/978-981-15-4501-6_158-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-4501-6

  • Online ISBN: 978-981-15-4501-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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