Abstract
In recent years, diabetic kidney disease has been the main cause of end-stage renal disease; more and more people have faced this serious public health problem worldwide. Autophagy is a conserved multistep pathway that degrades and recycles damaged organelles and macromolecules to maintain intracellular homeostasis. Autophagy plays key roles in several diseases, including kidney diseases. It has been suggested that dysregulated autophagy plays a vital role in both glomerular and tubulointerstitial pathologies in kidneys under diabetic conditions. The advances in our understanding of autophagy in diabetic kidney disease will be helpful for us to discover a new therapeutic target for the prevention and treatment of this life-threatening diabetes complication.
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References
Ahmed N (2005) Advanced glycation endproducts–role in pathology of diabetic complications. Diabetes Res Clin Pract 67:3–21
Chowdhury S, Ghosh S, Das AK, Sil PC (2019) Ferulic acid protects hyperglycemia-induced kidney damage by regulating oxidative insult inflammation and autophagy. Front Pharmacol 10:27
Dong D, Fan TT, Ji YS, Yu JY, Wu S, Zhang L (2019) Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes. Int Urol Nephrol
Najafian B, Alpers CE, Fogo AB (2011) Pathology of human diabetic nephropathy. Contrib Nephrol 170:36–47
Takahashi A, Takabatake Y, Kimura T, Maejima I, Namba T, Yamamoto T, Matsuda J, Minami S, Kaimori JY, Matsui I, Matsusaka T, Niimura F, Yoshimori T, Isaka Y (2017) Autophagy inhibits the accumulation of advanced glycation end products by promoting lysosomal biogenesis and function in the kidney proximal tubules. Diabetes 66:1359–1372
Yang D, Livingston MJ, Liu Z, Dong G, Zhang M, Chen JK, Dong Z (2018) Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential. Cell Mol Life Sci 75:669–688
Zhan H, Jin J, Liang S, Zhao L, Gong J, He Q (2019) Tripterygium glycoside protects diabetic kidney disease mouse serum-induced podocyte injury by upregulating autophagy and downregulating beta-arrestin-1. Histol Histopathol 18097
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Cui, J., Bai, X., Chen, X. (2020). Autophagy and Diabetic Nephropathy. In: Le, W. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1207. Springer, Singapore. https://doi.org/10.1007/978-981-15-4272-5_36
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DOI: https://doi.org/10.1007/978-981-15-4272-5_36
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