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Endocrine-Disrupting Chemical Exposure and Later-Onset Diseases

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Early-life Environmental Exposure and Disease

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Abstract

The ‘developmental origins of health and disease’ (DOHaD) suggests that early-life stress can affect the risk of later-onset diseases, while the potential mechanisms remain largely unknown. Epigenetics is defined as changes in gene expression that occur without changes in DNA sequence and can be transmitted to offspring. Increasing evidence has suggested that epigenetic regulation might be involved in developmental programming of late-onset pathologies. Here, we review current understandings of the relationship between early-life exposure of several endocrine-disrupting chemicals (EDCs) and later-life diseases, as well as potential epigenetic mechanisms.

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Acknowledgments

This study was supported by the National Natural Science Foundation of China (81402706), the Natural Science Foundation of Jiangsu Province (BK20181366).

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  1. School of Public Health, Nanjing Medical University, Nanjing, China

    Di Wu & Guizhen Du

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  1. Di Wu
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  2. Guizhen Du
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Correspondence to Guizhen Du .

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  1. School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China

    Yankai Xia

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Wu, D., Du, G. (2020). Endocrine-Disrupting Chemical Exposure and Later-Onset Diseases. In: Xia, Y. (eds) Early-life Environmental Exposure and Disease. Springer, Singapore. https://doi.org/10.1007/978-981-15-3797-4_11

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