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Multiple Pregnancies as a Complication of Medically Assisted Reproduction

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Abstract

Multiple gestations have long been a subject of interest to the medical community. In 1895, Polish pathologist Dyonizy Hellin established a formula for calculating the rate of multiples in the general population: he estimated twinning in 1 in 89 pregnancies; triplets 1 in 892, or 7921; and quadruplets 1 in 893, or 704,969. To this day, these calculations provide a reasonable approximation of naturally occurring multiple pregnancy rates [Fellman J, Eriksson AW (Twin Res Hum Genet 12:183–90, 2009)]. However, current worldwide rates of multiple gestations significantly outpace Hellin’s law. Why? The introduction of fertility treatments has caused an explosion of multiple gestations, especially in higher-order multiples (triplets or greater). Recent estimates show that 36% of twin births and 77% of high-order births result from fertility treatments.

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Authors and Affiliations

  1. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    John Wu, David Prokai & Orhan Bukulmez

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  1. John Wu
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  2. David Prokai
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  3. Orhan Bukulmez
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Correspondence to Orhan Bukulmez .

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Editors and Affiliations

  1. Consultant Reproductive Endocrinology & IVF Millennium Medical Center MMC IVF, Dubai Health Care City, Dubai, United Arab Emirates

    Gautam Nand Allahbadia

  2. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Koç University School of Medicine, Istanbul, Turkey

    Baris Ata

  3. Department of Obstetrics and Gynecology, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA

    Steven R. Lindheim

  4. X&Y Fertility, Leicester, UK

    Bryan J. Woodward

  5. School of Medicine and Dentistry, University of Rochester Medical Center, Newyork, USA

    Bala Bhagavath

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Wu, J., Prokai, D., Bukulmez, O. (2020). Multiple Pregnancies as a Complication of Medically Assisted Reproduction. In: Allahbadia, G.N., Ata, B., Lindheim, S.R., Woodward, B.J., Bhagavath, B. (eds) Textbook of Assisted Reproduction. Springer, Singapore. https://doi.org/10.1007/978-981-15-2377-9_41

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