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Infrared Spectroscopy

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Essentials of Pharmaceutical Analysis

Abstract

Infrared spectroscopy deals with the interaction of infrared (IR) region of electromagnetic spectrum with that of analyte present in sample. The absorption of electromagnetic radiation (EMR) in IR region is based on resonant frequency, i.e., absorption happens when natural frequency of vibration of bonds and groups matches with applied frequency. In this chapter, we have comprehensively described the various types of vibration of bonds or groups. There are multiple components associated with IR spectroscopy that are needed for its proper functioning. IR spectroscopy is useful for the analysis of sample existing in any form either solid, liquid, or gas. However, different sampling techniques are used for the preparation of sample to be analyzed by IR spectroscopy. A comparison of different types of IR spectroscopy is also given in this chapter. At the end, various applications of this spectroscopy have been described along with advantages and disadvantages.

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Further Reading

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  • Pavia DL, Lampman GM, Kriz GS, Vyvyan JA (2008) Introduction to spectroscopy. Cengage Learning, Belmont

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  • Stuart B (2000) Infrared spectroscopy. In: Kirk-Othmer encyclopedia of chemical technology. Wiley, Hoboken, pp 1–18

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  • Stuart B (2004) Infrared spectroscopy: fundamentals and applications. Wiley, West Sussex 10:0470011149

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  • Sudha PC (2012) Pharmaceutical analysis. Pearson Education India, Chennai

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  • Waters Corporation. Infrared spectroscopy. Accessed 10 July 2019

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  • Watson DG (2015) Pharmaceutical analysis E-book: a textbook for pharmacy students and pharmaceutical chemists. Elsevier Health Sciences, Amsterdam

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  • Wilson K, Walker J (2010) Principles and techniques of biochemistry and molecular biology. Cambridge University Press, Cambridge

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Akash, M.S.H., Rehman, K. (2020). Infrared Spectroscopy. In: Essentials of Pharmaceutical Analysis. Springer, Singapore. https://doi.org/10.1007/978-981-15-1547-7_4

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