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Exploring Endoperoxides as Leishmanicidal Compounds

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Oxidative Stress in Microbial Diseases

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Abstract

With advances in genomics, proteomics, and bioinformatics, identification of unique parasite-specific metabolic pathways has facilitated development of antileishmanial chemotherapeutics. In view of Leishmania parasites having a compromised antioxidant defense mechanism, induction of oxidative stress is a universal strategy adopted by conventional antileishmanial drugs with mitochondrial dysfunction being the major source of free radicals. However, a limitation is that mammalian mitochondria too are inhibited. Therefore, an attractive therapeutic option would be compounds like endoperoxides which owing to their unusual peroxide bridge mediate parasiticidal activity primarily via generation of free radicals. Accordingly, exploring the leishmanicidal potential of endoperoxides like artemisinin and ascaridole having established antimalarial and antihelminthic properties respectively, was the focus of this study. Leishmania proved to be a susceptible target for these free radical generating endoperoxides, making this therapeutic modality worthy of future pharmacological consideration.

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  1. Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India

    Sritama De Sarkar & Mitali Chatterjee

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  1. Sritama De Sarkar
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  2. Mitali Chatterjee
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Correspondence to Mitali Chatterjee .

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  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Amity University, Kolkata, West Bengal, India

    Dhrubajyoti Chattopadhyay

  4. National Institute of Immunology, New Delhi, India

    Chandrima Shaha

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De Sarkar, S., Chatterjee, M. (2019). Exploring Endoperoxides as Leishmanicidal Compounds. In: Chakraborti, S., Chakraborti, T., Chattopadhyay, D., Shaha, C. (eds) Oxidative Stress in Microbial Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8763-0_24

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