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Oxidative Stress Regulation in Giardia lamblia

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Oxidative Stress in Microbial Diseases

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Abstract

Giardia lamblia is a common gut parasite that infects the human gastrointestinal tract and causes 280 million cases of diarrhea every year. There are several reports on oxidative stress management in G. lamblia and how Giardia establishes its pathogenesis against the high oxygen tension in the gut. Here we have discussed about four oxidative stress-generating conditions which are actually mimicking the environment where Giardia resides. This chapter explored the fact that pyruvate, a crucial intermediary metabolite, acts as an antioxidant. This chapter has also elucidated the conserved and stress-specific responses of the trophozoite under different stressed conditions. The chapter will unveil the information generated by proteomic study. The chapter will also reveal how oxidative stress regulation works in Giardia trophozoites.

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Authors and Affiliations

  1. Vivekananda College, Kolkata, India

    Dibyendu Raj

  2. Division of Parasitology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India

    Dibyendu Raj & Sandipan Ganguly

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  1. Dibyendu Raj
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  2. Sandipan Ganguly
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Correspondence to Sandipan Ganguly .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Amity University, Kolkata, West Bengal, India

    Dhrubajyoti Chattopadhyay

  4. National Institute of Immunology, New Delhi, India

    Chandrima Shaha

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Raj, D., Ganguly, S. (2019). Oxidative Stress Regulation in Giardia lamblia . In: Chakraborti, S., Chakraborti, T., Chattopadhyay, D., Shaha, C. (eds) Oxidative Stress in Microbial Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8763-0_15

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