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Efficient Total Synthesis of Ōmura Natural Products

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Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules

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Abstract

Naturally occurring novel bioactive microbial metabolites have been discovered by a variety of customized screening methods in the Kitasato Institute, which have been promising to subsequently develop into novel and extremely useful pharmaceutical products. This chapter provides an overview of this research, encompassing the isolation, the total synthesis, and the analogue synthesis as well as the determination of the absolute stereochemistry of bioactive microbial metabolites, such as pyripyropenes (cholesterol lowering agents), arisugacins (acetylcholinesterase inhibitors), lactacystin (proteasome inhibitor), macrosphelides (cell-cell adhesion inhibitors), madindolines (IL-6 modulators), and neoxaline (cell proliferation inhibitor).

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Acknowledgments

We thank all of our co-workers who carried out the research described here; their names are listed in the references. This work was supported in part by a Grant of the twenty-first Century COE Program, Ministry of Education, Culture, Sports, Science and Technology (MEXT), the Japan Science and Technology Corporation (JST), a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan, and the Japan Keirin Association.

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  1. Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute, Tokyo, Japan

    Toshiaki Sunazuka, Tomoyasu Hirose & Satoshi Ōmura

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  1. Toshiaki Sunazuka
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  2. Tomoyasu Hirose
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  3. Satoshi Ōmura
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Correspondence to Toshiaki Sunazuka .

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  1. Department of Biotechnology, Tokyo Institute of Technology, Yokohama, Japan

    Yuichi Kobayashi

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Sunazuka, T., Hirose, T., Ōmura, S. (2019). Efficient Total Synthesis of Ōmura Natural Products. In: Kobayashi, Y. (eds) Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules. Springer, Singapore. https://doi.org/10.1007/978-981-13-6244-6_2

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