Abstract
Electroporation is a phenomenon that increases cells permeability due to applications of electric fields. Electrochemotherapy uses electroporation to facilitate drugs insertion into tumor cells. Guarantee that all tumor tissue will be electroporated is vital to treatment success. Needle electrodes can present complex electric field distribution. This paper aims to study electric field changes due to variations in electrodes and application protocols parameters. Besides, we suggest a superposition approach to improve electroporation treatment.
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References
Yarmush, M.L., Golberg, A., Sersa, G., Kotnik, T., Miklavcic, D.: Electroporation-based technologies for medicine: principles, applications, and challenges. Annu. Rev. Biomed. Eng. 16, 295–320 (2014). https://doi.org/10.1146/annurev-bioeng-071813-104622. PMID: 24905876
Ivorra, A.: Tissue electroporation as a bioelectric phenomenon: basic concepts, 23–61 (2009). https://doi.org/10.1007/978-3-642-05420-42
Mir, L.M., Orlowski, S., Belehradek, J., Paoletti, C.: Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur. J. Cancer Clin. Oncol. 27, 68–72 (1991). https://doi.org/10.1016/0277-5379(91)90064-K
Mir, L.M., Gehl, J., Sersa, G., et al.: Standard operating procedures of the electrochemotherapy: instructions for the use of bleomycin nor cisplatin administered either systemically or locally and electric pulses delivered by the Cliniporator (TM) by means of invasive or non-invasive electrodes. EJC Suppl. 4, 14–25 (2006). https://doi.org/10.1016/j.ejcsup.2006.08.003
Miklav, I.D., Mali, B., Kos, B., Heller, R., Ser, A.G.: Electrochemotherapy: from the drawing board into medical practice. Biomed. Eng. Online 13, 29 (2014). https://doi.org/10.1186/1475-925X-13-29
Suzuki, D.O., Anselmo, J., Oliveira, K.D., et al.: Numerical model of dog mast cell tumor treated by electrochemotherapy. Artif. Organs 39, 192–197. https://doi.org/10.1111/aor.12333.7
Suzuki, D., Marques, C., Rangel, M.: Conductive gel increases the small tumor treatment with electrochemotherapy using needle electrodes. Artif. Organs 40, 705–711 (2015). https://doi.org/10.1111/aor.12631.8
Suzuki, D.O., Berkenbrock, J.A., Oliveira, K.D., Freytag, J.O., Rangel, M.M.: Novel application for electrochemotherapy: immersion of nasal cavity in dog. Artif. Organs 41, 767–773. https://doi.org/10.1111/aor.12858.9
Sel, D., Cukjati, D., Batiuskaite, D., Slivnik, T., Mir, L.M., Miklavcic, D.: Sequential finite element model of tissue electropermeabilization. IEEE Trans. Biomed. Eng. 52, 816–827 (2005). https://doi.org/10.1109/TBME.2005.845212.10
Corovic, S., Lackovic, I., Sustaric, P., Sustar, T., Rodic, T., Miklavcic, D.: Modeling of electric field distribution in tissues during electroporation. Biomed. Eng. Online 12, 16 (2013). https://doi.org/10.1186/1475-925X-12-16.11
Veldhuisen, E., Vogel, J.A., Klaessens, J.H., Verdaasdonk, R.M.: Thermal effects of irreversible electroporation, pp. 121–136. Springer, Cham (2018). https://doi.org/10.1007/978-3-319-55113-59.12
Garcia, P., Davalos, R., Miklavcic, D.: A numerical investigation of the electric and thermal cell kill distributions in electroporation-based therapies in tissue. PLoS ONE (2014). https://doi.org/10.1371/journal.pone.0103083
Acknowledgements
This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. We would like to thank the Brazilian research funding agencies CAPES and CNPq for the scholarships granted to the post-graduate students.
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da Silva, J.R., Guedert, R., Pintarelli, G.B., Suzuki, D.O.H. (2020). Computational Study of Parameters of Needle Electrodes for Electrochemotherapy. In: Bertemes-Filho, P. (eds) 17th International Conference on Electrical Bioimpedance. ICEBI 2019. IFMBE Proceedings, vol 72. Springer, Singapore. https://doi.org/10.1007/978-981-13-3498-6_29
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DOI: https://doi.org/10.1007/978-981-13-3498-6_29
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