Skip to main content
SpringerLink
Log in

Research Progress of Burn Infection

  • Chapter
  • First Online:
Severe Trauma and Sepsis

  • 704 Accesses

Abstract

Infection is one of the leading causes of death in severely burned patients. Because of the destruction of the physiological defense barrier in the body surface and the decline of systemic immune function in severe burn patients, the presence of a wide range of necrotic tissues and the invasion of the external and internal bacterial flora have increased the susceptibility to infection. So it can be said that the threat of local or systemic infection after burns starts from the burn injuries and ends till the wound heals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Peng YZ, Chen J, Yuan ZQ, Li XL, Luo GX, Wu J. Diagnostic criteria and treatment protocol for post-burn sepsis. Crit Care. 2013;17(1):406.

    Article  Google Scholar 

  2. Gong YL, Chen J, Liu CJ, Zhang C, Luo XQ, Peng YZ. Comparison of pathogens and antibiotic resistance of burn patients in the burn ICU or in the common burn ward. Burns. 2014;40:402–7.

    Article  Google Scholar 

  3. Appelgren P. A prospective study of infections in burn patients. Burns. 2002;28(1):39–46.

    Article  Google Scholar 

  4. Peng YZ, Yuan ZQ. Standardized definitions and diagnostic criteria for infection in bum patients. Chin J Burns. 2007;23(6):404–5.

    Google Scholar 

  5. Pham TN, Neff MJ, Simmons JM, Gibran NS, Heimbach DM, Klein MB. The clinical pulmonary infection score poorly predicts pneumonia in patients with burns. J Burn Care Res. 2007;28(1):76–9.

    Article  Google Scholar 

  6. Zhang YP. Infection of burn opportunistic bacteria and its deep dissemination. Chin J Surg. 1989;27:751.

    Google Scholar 

  7. Ma L, Xiao GX. Burn injury and intestinal infection. Acta Acad Med Mil Tert. 1990;12:6.

    Google Scholar 

  8. Fang L, Wang F, Sun K, et al. Analysis on the prevalence of central venous catheter-related infection in burn patients and its risk factors. Chin J Burns. 2016;32:243–8.

    Google Scholar 

  9. Gong YL, Yang ZC, Yin SP, Liu MX, Zhang C, Luo XQ, Peng YZ. Analysis of the pathogenic characteristics of 162 severely burned patients with bloodstream infection. Chin J Burns. 2016;32(09):529–35.

    CAS  Google Scholar 

  10. Xiao GX. Clinical significance of quantitative culture of bacteria in burn patients. Med J Chin PLA. 1981;6:319.

    Google Scholar 

  11. Deitch EA. Gut-origin sepsis: evolution of a concept. Surgeon. 2012;10:350–6.

    Article  Google Scholar 

  12. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Intensive Care Med. 2003;29(4):530–8.

    Article  Google Scholar 

  13. Alexander C, Rietschel ET. Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res. 2001;7:167–202.

    CAS  Google Scholar 

  14. Goodwin CW. Parenteral nutrition in thermal injuries. In: Rombeau JL, editor. Clinical nutrition: parenteral nutrition. Philadelphia, PA: W. B. Saunders; 1993. p. 566–84.

    Google Scholar 

  15. Rotstein OD, Meakins JL. Diagnostic and therapeutic challenges of intraabdominal infections. World J Surg. 1990;14:159–66.

    Article  CAS  Google Scholar 

  16. Peng YZ, Xiao GX. Intestinal infection and intestinal lymph circulation after severe burn. Chin J Plast Surg. 1996;12(3):483.

    Google Scholar 

  17. Peng YZ, Xiao GX, Wang DW, et al. Role of lipid peroxidation in bacterial translocation from the small intestine after thermal injury in rats. J Med Coll PLA. 1990;5(3):271–7.

    Google Scholar 

  18. Morehouse JL, Specian RD, Stewart JJ, et al. Translocation of indigenous bacteria from the gastrointestinal tract of mice after oral ricinoleic acid treatment. Gastroenterology. 1986;91:673–82.

    Article  CAS  Google Scholar 

  19. Peng YZ, Xiao GX. 42 years’ experience on the prevention and treatment of systemic infection after severe burn. Chin J Burns. 2001;4(7):93.

    Google Scholar 

  20. Greenhalgh DG. Sepsis in the burn patient: a different problem than sepsis in the general population. Burns Trauma. 2017;5:23.

    Article  Google Scholar 

  21. Peng YZ, Xiao GX. Early enteral feeding reduced the level of endotoxin in the intestinal lymph of rats with severe scald injury. Chin J Plast Surg. 1998;14(2):83.

    Google Scholar 

  22. Yang ZC, Deng LY, Gong YL, Yin SP, Jiang B, Huang GT, Peng YZ, Hu FQ. Inventory building of phages against extensively drug-resistant Acinetobacter baumannii isolated from wounds of patients with severe burn and related characteristic analysis. Chin J Burns. 2016;32(09):517–22.

    CAS  Google Scholar 

  23. Mousa HA. Correlation between fungi isolated from burn wounds and burn care units. Burns. 1999;25(2):145–7.

    Article  CAS  Google Scholar 

  24. Xiao GX, et al. Early diagnosis of Aspergillus infection after burns. Acta Acad Med Mil Tert. 1982;4:124.

    Google Scholar 

  25. Wang DW, et al. A preliminary study of anaerobic bacterial infection in burn patients. Chin J Surg. 1983;21:399.

    CAS  PubMed  Google Scholar 

  26. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644–55.

    Article  CAS  Google Scholar 

  27. Greenhalgh DG, Saffle JR, Holmes JH, et al. American Burn Association Consensus Conference to define sepsis and infection in burns. J Burn Care Res. 2007;28(6):776–90.

    Article  Google Scholar 

  28. Peng YZ. Clinical characteristics and diagnosis of sepsis in pediatric burn patients. Chin J Burns. 2013;29(1):1–3.

    Google Scholar 

  29. Wang F, Hu GZ, Chen J, Gong YL, Yuan ZQ, Peng YZ. Prognostic significance of serum procalcitonin in patients with burn sepsis. Chin J Burns. 2014;30(3):223–6.

    CAS  Google Scholar 

  30. Sun YH. Burn sepsis and multiple organ dysfunction syndrome. Chin J Burns. 2001;17(3):189–90.

    Google Scholar 

  31. Xiao GX. The retrospect and the prospect of our country’s prevention and treatment of burn injury. Chin J Burns. 2000;9(2):69.

    Google Scholar 

  32. Li HM, Zhang JP, Chen J, Song HP, Liu QS, Fan X, Peng YZ, Wu J. Integration of burn treatment and rehabilitation for a child with extremely severe burn. Chin J Burns. 2015;31(2):130–4.

    Google Scholar 

  33. Peng YZ. Improving the management of deep partial thickness burn wound. Chin J Burns. 2005;21(1):12–3.

    Google Scholar 

  34. Xu WS. Empirical application of antibiotics in burn infection. Chin J Burns. 2002;18(2):71–2.

    Google Scholar 

  35. Zheng F, Wang D, Liu N, Shao X, Jin X. Analysis of evaluation indexes for prognosis of severe burn patients with sepsis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29(4):327–31.

    PubMed  Google Scholar 

  36. Uchino S, Bellomo R, Goldsmith D, Davenport P, et al. Super high flux hemofiltration: a new technique for cytokine removal. Intensive Care Med. 2002;28:651.

    Article  CAS  Google Scholar 

  37. Ronco C, Tetta C, Mariano F. Interpreting the mechanisms of continuous renal replacement therapy in sepsis: the peak concentration hypothesis. Artif Organs. 2003;27(9):792–801.

    Article  Google Scholar 

  38. You B, Zhang YL, Luo GX, et al. Early application of continuous high-volume haemofiltration can reduce sepsis and improve the prognosis of patients with severe burns. Crit Care. 2018;22:173.

    Article  Google Scholar 

  39. Sun KD, Dong ZW, Chen J, Liu P, Gong YL, Peng YZ. Effects of early oral administration of mixed enteral nutritional agent on intestinal mucosal barrier of patients with severe burn injury. Chin J Burns. 2015;31(1):25–9.

    CAS  Google Scholar 

  40. Peng YZ, Yuan ZQ, Xiao GX. Effects of early enteral feeding on the prevention of enterogenous infection in severely burned patients. Burns. 2001;27:145–9.

    Article  CAS  Google Scholar 

  41. Morgera S, Slowinski T, Melzer C, et al. Renal replacement therapy with high-cutoff hemofilters: impact of convection and diffusion on cytokine clearances and protein status. Am J Kidney Dis. 2004;43(3):444–53.

    Article  CAS  Google Scholar 

  42. Peng YZ, Yuan ZQ, Li HB. Removal of inflammatory cytokines and endotoxin by veno-venous continuous renal replacement therapy for burned patients with sepsis. Burns. 2005;31:623–8.

    Article  Google Scholar 

  43. Orr PA, Case KO, Stevenson JJ. Metabolic response and parenteral nutrition in trauma, sepsis, and burns. J Infus Nurs. 2002;25(1):45–53.

    Article  Google Scholar 

  44. Greenfield E. Infectious complications: prevention and strategies for their control. Nurs Clin North Am. 1997;32(2):297–309.

    CAS  PubMed  Google Scholar 

  45. Xiao GX. 20 years experience in the treatment of extensive third degree burns. Med J Chin PLA. 1979;4:70.

    Google Scholar 

  46. Yao YM, Sheng ZY, Chai JK. The pathogenesis and management of severe sepsis after burns. Chin J Burns. 2008;24(5):337–9.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing, P. R. China

    Zichen Yang & Yizhi Peng

Authors
  1. Zichen Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yizhi Peng
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Wound Healing and Cell Biology Lab, First Affiliated Hospital, Chinese PLA General Hospital, Beijing, China

    Xiaobing Fu

  2. State Key Laboratory of Trauma, Burns, and Combined Injury, Daping Hospital, Third Military Medical University, Chong Qing, China

    Liangming Liu

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Yang, Z., Peng, Y. (2019). Research Progress of Burn Infection. In: Fu, X., Liu, L. (eds) Severe Trauma and Sepsis. Springer, Singapore. https://doi.org/10.1007/978-981-13-3353-8_13

Download citation

  • DOI: https://doi.org/10.1007/978-981-13-3353-8_13

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-3352-1

  • Online ISBN: 978-981-13-3353-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation