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PIK3-AKT and Its Role in Pancreatic Cancer

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Role of Tyrosine Kinases in Gastrointestinal Malignancies

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Abstract

The pancreas plays an important role in our body to help with maintaining and regulating homeostatic conditions. One of the cellular pathways that play a major role in pancreatic cell growth and division is the phosphatidylinositol-3-kinase-AKT pathway. According to current research studies, even the smallest changes to the phosphatidylinositol-3-kinase-AKT can cause abnormal cellular growth leading to the development of cancerous cells. Currently, there are many treatment options which are targeting the PI3K-AKT signaling pathway. This chapter examines the function of phosphatidylinositol-3-kinase-AKT pathway in pancreatic cancer and discusses current research studies that focus on potential treatment options.

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Author information

Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA-30322, USA

    Saimila Momin

  2. Department of Hematology and Medical Oncology, School of Medicine, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Ganji Purnachandra Nagaraju

Authors
  1. Saimila Momin
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  2. Ganji Purnachandra Nagaraju
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Correspondence to Ganji Purnachandra Nagaraju .

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Editors and Affiliations

  1. Department of Hematology and Medical Oncology, School of Medicine, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Ganji Purnachandra Nagaraju

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Momin, S., Nagaraju, G.P. (2018). PIK3-AKT and Its Role in Pancreatic Cancer. In: Nagaraju, G. (eds) Role of Tyrosine Kinases in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-13-1486-5_4

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