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Regulation of Lipolysis in Adipose Tissue and Clinical Significance

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Neural Regulation of Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1090))

Abstract

Lipolysis is a critical process to hydrolyze triglyceride in adipose tissue, thereby breaking down the stored lipid and maintaining energy homeostasis. Recent studies have made significant progress in understanding the steps of lipolysis. This chapter discusses the major pathways that regulate lipolysis in adipose tissue. Specifically we focus on the mechanisms by which the activities of critical lipolytic enzymes are regulated. We further discuss how the lipolysis is regulated by other factors, including insulin and neurotransmitters, in particular catecholamines and the role of sympathetic nervous system in the whole process. Finally we provide clinical perspectives about the novel therapeutic strategies to target or promote adipose tissue lipolysis for treatment/prevention of obesity and type 2 diabetes.

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Acknowledgments

Research in Dr. Sun’s lab is supported by NIH grant R01DK109001.

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Authors and Affiliations

  1. Center for Metabolic and Degenerative Diseases, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA

    Xin Li & Kai Sun

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  1. Xin Li
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Correspondence to Kai Sun .

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Editors and Affiliations

  1. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

    Qi Wu

  2. Department of Anatomy, Histology and Embryology, Health Science Center, Peking University, Beijing, China

    Ruimao Zheng

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Li, X., Sun, K. (2018). Regulation of Lipolysis in Adipose Tissue and Clinical Significance. In: Wu, Q., Zheng, R. (eds) Neural Regulation of Metabolism. Advances in Experimental Medicine and Biology, vol 1090. Springer, Singapore. https://doi.org/10.1007/978-981-13-1286-1_11

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