Abstract
In addition to size, shape plays an important role when nanoparticle interacts with a cell. Mathematical model was formulated to predict membrane elastic energy in the presence of hydrophobic cylindrical nanoparticle. Two states of nanoparticle-phosholipid complexes were studied: the micellar complex with a nanoparticle encapsulated in the phospholipid monolayer and the lamellar complex where a nanoparticle is trapped inside the lipid bilayer. It was shown that there exists a critical size for the cylindrical nanoparticle below which the lamellar state is energetically more favorable. However, the critical size of cylindrical nanoparticle is considerably lower than the one of spherical nanoparticle. It might be concluded, that biological activity of cylindrical nanoparticle in comparison to spherical nanoparticles might be attributed not only to its higher area to volume ratio, but also to lower critical size. Lower critical size prevents a nanoparticle to be trapped inside the lipid bilayer and facilitates its translocation through phosholipid bilayer.
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Acknowledgements
The study was supported by projects of the Czech Health Research Council 15-33629A and the Czech Science Foundation 16-14758S and the CTU in Prague SGS project No. SGS17/157/OHK4/2T/17.
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Otáhal, M., Řezníčková, J., Daniel, M. (2019). Can Be Minimization of Membrane Bending Energy Used for Simulation of the Nanoparticle-Cell Interaction?. In: Lhotska, L., Sukupova, L., Lacković, I., Ibbott, G. (eds) World Congress on Medical Physics and Biomedical Engineering 2018. IFMBE Proceedings, vol 68/2. Springer, Singapore. https://doi.org/10.1007/978-981-10-9038-7_136
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