Abstract
Lycorine is extracted from lycoris radiate, which is famous because galanthamine has been approved by FDA as an anti-Alzheimer disease drug. Lycoris radiate is the only natural source for galanthamine with extremely low content (<0.02%). The main active ingredients extracted from the lycoris radiate are about 40 alkaloids with various contents and lycorines are the major effective medicinal ingredients. Lycorine and its derivatives have various pharmacological effects, including anti-inflammatory, antiviral, anti-malaria, acetylcholine esterase inhibition, cardiovascular protection, and antitumor. The in-depth studies on such compounds may fully take advantage of the natural resources in China to develop an innovative drug which is effective in the treatment of serious diseases including tumor, senile dementia, and virus infection. In conclusion, the research and development of an innovative drug relating to lycorine and its derivatives deserve much attention from both scientists and researchers.
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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
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Bai, XY., Du, LD., Du, GH. (2018). Lycorine. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_96
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DOI: https://doi.org/10.1007/978-981-10-8022-7_96
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