Abstract
Luteolin is extracted from Honeysuckle金银花 (Lonicera japonica Thunb), which is the most important flavone in Honeysuckle. Plants rich in luteolin have been used for treating various diseases such as hypertension, inflammatory disorders, and cancer. The biological effects of luteolin could be functionally related to each other. For instance, the anti-inflammatory activity may be linked to its anticancer property. Luteolin can selectively inhibit the fatty acid synthase activity in prostate cancer and breast cancer cells, which is related to the inhibitory effect of luteolin on tumor cell growth and apoptosis. Luteolin can enhance the transfer of synapses in the hippocampus dentate gyrus, causing long-term potentiation. Most studies on luteolin were carried out in vitro, lacking in vivo experimental results. Therefore, it is necessary to further explore the pharmacological activity and pharmacokinetics of luteolin in vivo, so as to provide a solid theoretical basis for its clinical application.
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References
López-Lázaro M. Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem. 2009;9(1):31–59.
Lin Y, Shi R, Wang X, et al. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets. 2008;8(7):634–46.
Rao PS. Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: involvement of cell line-specific apoptotic mechanisms. Int J Cancer. 2012;130(11):2703–14.
Dajas F, Rivera-Megret F, Blasina F, et al. Neuroprotection by flavonoids. Braz J Med Biol Res. 2003;36:1612–20.
Wang J, He Y, Zhang W, et al. Advances in studies on pharmacological effects of luteolin. Chin Bull Life Sci. 2013;25(6):560–5.
Han W, Xing Y, Kang T. Advances in studies on biological activities of Luteolin. Yunnan J Tradit Chin Med Matera Med. 2010;31(4):60–2.
Ulubelen A, Miski M, Neuman P, et al. Flavonoids of Salvia tomentosa (Labiatae). J Nat Prod. 1979;42(4):261–3.
Zhao G, Qin GW, Wang J, et al. Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt. Neurochem Int. 2010;56(1):168–76.
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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
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He, GR., Wang, SB., Du, GH. (2018). Luteolin. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_114
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DOI: https://doi.org/10.1007/978-981-10-8022-7_114
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