Abstract
As traditional molecular imaging modalities, the nature and physical fundamentals of MRI, US, OI, radionuclide-based PET/SPECT imaging, X-ray, and CT are elucidated in this chapter. The philosophy for the design, fabrication, and application of representative imaging probes are also described. Meanwhile, advanced imaging modalities and hybrid imaging probes for both clinical and basic study uses are also introduced to present a clear understanding to a broad and interdisciplinary readership especially at the frontiers of molecular imaging research.
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References
Brown, M.A., Semelka, R.C.: MRI: Basic Principles and Applications. Wiley (2011)
Ogawa, S., Tank, D.W., Menon, R., Ellermann, J.M., Kim, S.G., Merkle, H.: Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc. Nat. Acad. Sci. USA 89, 5951 (1992)
Devuyst, G., Bogousslavsky, J., Ruchat, P., Jeanrenaud, X., Despland, P.A., Regli, F.: Prognosis after stroke followed by surgical closure of patent foramen ovale: a prospective follow-up study with brain MRI and simultaneous transesophageal and transcranial doppler ultrasound. Neurology 47, 1162–1166 (1996)
Tang, H., Wu, E.X., Ma, Q.Y., Gallagher, D., Perera, G.M., Zhuang, T.: MRI brain image segmentation by multi-resolution edge detection and region selection. Comput. Med. Imaging Graph. 24, 349 (2000)
Heckemann, R.A., Hajnal, J.V., Aljabar, P., Rueckert, D., Hammers, A.: Automatic anatomical brain MRI segmentation combining label propagation and decision fusion. Neuroimage 33, 115–126 (2006)
Osman, N.F., Mcveigh, E.R., Prince, J.L.: Imaging heart motion using harmonic phase MRI. IEEE T. Med. Imaging 19, 186–202 (2000)
Larson, A.C., White, R.D., Laub, G., Mcveigh, E.R., Li, D., Simonetti, O.P.: Self-gated cardiac cine MRI. Magn. Reson. Med. 51, 93 (2004)
Otazo, R., Kim, D.L., Sodickson, D.K.: Combination of compressed sensing and parallel imaging for highly accelerated first-pass cardiac perfusion MRI. Magn. Reson. Med. 64, 767–776 (2010)
Haacke, E.M., Masaryk, T.J., Wielopolski, P.A., Zypman, F.R., Tkach, J.A., Amartur, S.: Optimizing blood vessel contrast in fast three dimensional MRI. Magn. Reson. Med. 14, 202–221 (1990)
Stalder, A.F., Russe, M.F., Frydrychowicz, A., Bock, J., Hennig, J., Markl, M.: Quantitative 2d and 3d phase contrast MRI: optimized analysis of blood flow and vessel wall parameters. Magn. Reson. Med. 60, 1218 (2008)
Degani, H., Gusis, V., Weinstein, D., Fields, S., Strano, S.: Mapping pathophysiological features of breast tumors by MRI at high spatial resolution. Nat. Med. 3, 780–782 (1997)
Lewin, J.S., Connell, C.F., Duerk, J.L., Chung, Y.C., Clampitt, M.E., Spisak, J.: Interactive MRI-guided radiofrequency interstitial thermal ablation of abdominal tumors: clinical trial for evaluation of safety and feasibility. J. Magn. Reson. Imaging 8, 40 (1998)
Sipkins, D.A., Cheresh, D.A., Kazemi, M.R., Nevin, L.M., Bednarski, M.D., Li, K.C.: Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging. Nat. Med. 4, 623–626 (1998)
Gillies, R.J., Natarajan, R., Karczmar, G.S., Bhujwalla, Z.M.: MRI of the tumor microenvironment. J. Magn. Reson. Imaging 16, 430 (2002)
Barrett, T., Brechbiel, M., Bernardo, M., Choyke, P.L.: MRI of tumor angiogenesis. J. Magn. Reson. Imaging 26, 235–249 (2007)
Gadian, D.G.: NMR and its Applications to Living Systems. Oxford University Press (1995)
Callaghan, P.T.: Principles of Nuclear Magnetic Resonance Microscopy. Oxford University Press (1991)
Cassidy, P.J., Radda, G.K.: Molecular imaging perspectives. J. R. Soc. Interface 2, 133 (2005)
Padmanabhan, P., Kumar, A., Kumar, S., Chaudhary, R.K., Gulyas, B.: Nanoparticles in practice for molecular-imaging applications: an overview. Acta Biomater. 41, 1 (2016)
Boesch, C.: Molecular aspects of magnetic resonance imaging and spectroscopy. Mol. Aspects Med. 20, 185–318 (1999)
Bean, C.P., Livingston, J.D.: Superparamagnetism. J. Appl. Phys. 30, 120–129 (1959)
Kemshead, J.T., Ugelstad, J.: Magnetic separation techniques: their application to medicine. Mol. Cell. Biochem. 67, 11–18 (1985)
Bulte, J.W., Kraitchman, D.L.: Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed. 17, 484–499 (2004)
Massart, R., Cabuil, V.: Effect of some parameters on the formation of colloidal magnetite in alkaline medium-yield and particle-size control. J. Chem. Phys. 84, 967–973 (1987)
Sun, S., Zeng, H.: Size-controlled synthesis of magnetite nanoparticles. J. Am. Chem. Soc. 124, 8204–8205 (2002)
Sonvico, F., Mornet, S., Vasseur, S., Dubernet, C., Jaillard, D., Degrouard, J., Hoebeke, J., Duguet, E., Colombo, P., Couvreur, P.: Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments. Bioconjugate Chem. 16, 1181–1188 (2005)
Kohler, N., Fryxell, G.E., Zhang, M.: A biofunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents. J. Am. Chem. Soc. 126, 7206–7211 (2004)
Kim, D.K., Toprak, M., Mikhailova, M., Zhang, Y., Bjelke, B., Kehr, J., Muhammed, M.: Surface modification of superparamagnetic nanoparticles for in-vivo bio-medical applications. Mat. Res. Soc. Symp. Proc 704, W11.2.1-6 (2002)
Zhou, J., Leuschner, C., Kumar, C., Hormones, J.F., Soboyejo, W.O.: Subecellular accumulation of magnetic nanoparticles in breast tumors and metastases. Biomaterials 27, 2001–2008 (2006)
Jin, R., Lin, B., Li, D., Ai, H.: Superparamagnetic iron oxide nanoparticles for MR imaging and therapy: design considerations and clinical applications. Curr. Opin. Pharm. 18, 18–27 (2014)
Gupta, A.K., Wells, S.: Surface-modified superparamagnetic nanoparticles for drug delivery: preparation, characterization, and cytotoxicity studies. IEEE T. Nanobiosci. 3, 66–73 (2004)
Gupta, A.K., Gupta, M.: Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26, 3995–4021 (2005)
Weissleder, R., Bogdanov, A., Neuwelt, E.A.: Long-circulating iron oxides for MR imaging. Adv. Drug Deliv. Rev. 16, 321–334 (1995)
Corot, C., Robert, P., Idee, J.M.: Recent advances in iron oxide nanocrystal technology for medical imaging. Adv. Drug Deliv. Rev. 58, 1471–1504 (2006)
Anzai, Y., Piccoli, C.W., Outwater, E.K.: Evaluation of neck and body metastases to nodes with ferumoxtran 10-enhanced MR imaging: phase III safety and efficacy study. Radiology 228, 777–788 (2003)
Weissleder, R., Stark, D.D., Engelstad, B.L.: Superparamagnetic iron oxide: pharmacokinetics and toxicity. Am. J. Roentgenol. 152, 167–173 (1989)
Wagner, S., Schnorr, J., Pilgrimm, H., Hamm, B., Taupitz, M.: Monomer-coated very small superparamagnetic iron oxide particles as contrast medium for magnetic resonance imaging: preclinical in vivo characterization. Invest. Radiol. 37, 167–177 (2002)
Chapon, C., Franconi, F., Lacoeuilie, F., Hindre, F., Saulnier, P., Benoit, J.P., Le Jeune, J.J., Lemaire, L.: Imaging E-selectin expression following traumatic brain injury in the rat using a targeted USPIO contrast agent. MAGMA 22, 167–174 (2009)
Michalska, M., Machtoub, L., Manthey, H.D., Bauer, E., Herold, V., Krohne, G., Lykowsky, G., Hildenbrand, M., Kampf, T., Jakob, P., Zernecke, A., Bauer, W.R.: Visualization of vascular inflammation in the atherosclerotic mouse by ultrasmall superparamagnetic iron oxide vascular cell adhesion molecule-1-specific nanoparticles. Arterioscler. Thromb. Vasc. Biol. 32, 2350–2357 (2012)
Shamsipour, F., Zarnani, A.H., Zarnani, A.H., Ghods, R., Chamankhah, M., Forouzesh, F., Vafaei, S., Bayat, A.A., Akhondi, M.M., Ali Oghabian, M., Jeddi-Tehrani, M.: Conjugation of monoclonal antibodies to super paramagnetic iron oxide nanoparticles for detection of HER2/neu antigen on breast cancer cell lines. Avicenna. J. Med. Biotechnol. 1, 27–31 (2009)
Meier, R., Henning, T.D., Boddington, S., Arora, S., Piontek, G., Rudelius, M., Corot, C., Daldrup-Link, H.E.: Breast cancers: MR imaging of folate-receptor expression with the folate-specific nanoparticle P1133. Radiology 255, 527–535 (2010)
Araki, T.: SPIO-MRI in the detection of hepatocellular carcinoma. J. Gastroenterol. 35, 874–876 (2000)
Lucidarme, O., Baleston, F., Cadi, M., Bellin, M.F., Charlotte, F., Ratziu, V., Grenier, P.A.: Non-invasive detection of liver fibrosis: is superparamagnetic iron oxide particle-enhanced MR imaging a contributive technique? Eur. Radiol. 13, 467–474 (2003)
Anzai, Y., Prince, M.R.: Iron oxide-enhanced MR lymphography: the evaluation of cervical lymph node metastases in head and neck cancer. J. Magn. Reson. Imaging 7, 75–81 (1997)
American national standard: acoustical terminology. American National Standard Institute, Acoustical Society of America, New York (1994)
Mitragotri, S.: Healing sound: the use of ultrasound in drug delivery and other therapeutic applications. Nat. Rev. Drug Discov. 4, 255–260 (2005)
Agrawal, P., Strijkers, G.J., Nicolay, K.: Chitosan-based systems for molecular imaging. Adv. Drug Deliv. Rev. 62, 42–58 (2010)
Paefgen, V., Doleschel, D., Kiessling, F.: Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery. Front. Pharm. 6, 197 (2015)
Cootney, R.W.: Ultrasound imaging: principles and applications in rodent research. ILAR J. 42, 233 (2001)
Pearlman, A.S., Stevenson, J.G., Baker, D.W.: Doppler echocardiography: applications, limitations and future directions. Am. J. Cardiol. 46, 1256–1262 (1980)
Izadifar, Z., Babyn, P., Chapman, D.: Mechanical and biological effects of ultrasound: A review of present knowledge. Ultrasound Med. Biol. 43, 1085–1104 (2017)
Ter Haar, G.: Therapeutic applications of ultrasound. Prog. Biophys. Mol. Biol. 93, 111–129 (2007)
Miller, M.W., Miller, D.L., Brayman, A.A.: A review of in vitro bioeffects of inertial ultrasonic cavitation from a mechanistic perspective. Ultrasound Med. Biol. 22, 1131–1154 (1996)
Gourevich, D., Volovick, A., Dogadkin, O., Wang, L., Mulvana, H., Medan, Y., Melzer, A., Cochran, S.: In vitro investigation of the individual contributions of ultrasound-induced stable and inertial cavitation in targeted drug delivery. Ultrasound Med. Biol. 41, 1853–1864 (2015)
Sierra, C., Acosta, C., Chen, C., Wu, S.Y., Karakatsani, M.E., Bernal, M., Konofagou, E.E.: Lipid microbubbles as a vehicle for targeted drug delivery using focused ultrasound-induced blood-brain barrier opening. J. Cereb. Blood Flow Metab. 37, 1236–1250 (2017)
Gramiak, R., Shah, P.: Echocardiography of the aortic root. Invest. Radiol. 3, 356–366 (1968)
Liu, Z., Kiessling, F., Gaetjens J.: Advanced nanomaterials in multimodal imaging: design, functionalization, and biomedical applications. J. Nanomater. (2010)
Abouelkacem, L., Bachawal, S.V., Willmann, J.K.: Ultrasound molecular imaging: moving toward clinical translation. Eur. J. Radiol. 84, 1685–1693 (2015)
Appis, A.W., Tracy, M.J., Feinstein, S.B.: Update on the safety and efficacy of commercial ultrasound contrast agents in cardiac applications. Echo Res. Pract. 2, R55–R62 (2015)
McCulloch, M., Gresser, C., Moos, S., Odabashian, J., Jasper, S., Bednarz, J., Burgess, P., Carney, D., Moore, V., Sisk, E., Waggoner, A., Witt, S., Adams, D.: Ultrasound contrast physics: a series on contrast echocardiography, article 3. J. Am. Soc. Echocardiogr. 13, 959–967 (2000)
Elsayed, M., Kothandaraman, A., Edirisinghe, M., Huang, J.: Porous polymeric films from microbubbles generated using a T-junction microfluidic device. Langmuir 32, 13377–13385 (2016)
Dolan, M.S., Dent, J., de Filippi, C., Christopher, T., Wible, J.H.: Increasing the dose and rate of Albunex infusion leads to superior left ventricular contrast effect. J. Am. Soc. Echocardiogr. 11, 426–432 (1998)
Drelich-Zbroja, A., Jargiello, T., Szymanska, A., Krzyzanowski, W., Szczerbo-Trojanowska, M.: Can Levovist-enhanced Doppler ultrasound replace angiography in abdominal branches of the aorta imaging? Ultrasound Med. Biol. 29, S195 (2003)
Von Herbay, A., Haeussinger, D., Gregor, M., Vogt, C.: Characterization and detection of hepatocellular carcinoma (HCC): comparison of the ultrasound contrast agents SonoVue (BR1) and Levovist (SHU508A)–comparison of SonoVue and Levovist in HCC. Ultraschall Med. 28, 168–175 (2007)
Miyamoto, Y., Ito, T., Takada, E., Omoto, K., Hirai, T., Moriyasu, F.: Efficacy of sonazoid (perflubutane) for contrast-enhanced ultrasound in the differentiation of focal breast lesions: phase 3 multicenter clinical trial. Am. J. Roentgenol. 202, W400–W407 (2014)
Ni, X., Ye, J., Wang, L., Xu, S., Zou, C., Yang, Y., Liu, Z.: Advanced microbubbles as a multifunctional platform combining imaging and therapy. Appl. Sci. 6, 365 (2016)
Machtaler, S., Knieling, F., Luong, R., Tian, L., Willmann, J.K.: Assessment of inflammation in an acute on chronic model of inflammatory bowel disease with ultrasound molecular imaging. Theranostics 5, 1175–1186 (2015)
Hu, G., Liu, C., Liao, Y., Yang, L., Huang, R., Wu, J., Xie, J., Bundhoo, K., Liu, Y., Bin, J.: Ultrasound molecular imaging of arterial thrombi with novel microbubbles modified by cyclic RGD in vitro and in vivo. Thromb. Haemost. 107, 172–183 (2012)
van Wamel, A., Kooiman, K., Harteveld, M., Emmer, M., ten Cate, F.J., Versluis, M., de Jong, N.: Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation. J. Control. Release 112, 149–155 (2006)
Schlicher, R.K., Radhakrishna, H., Tolentino, T.P., Apkarian, R.P., Zarnitsyn, V., Prausnitz, M.R.: Mechanism of intracellular delivery by acoustic cavitation. Ultrasound Med. Biol. 32, 915–924 (2006)
Prentice, P., Cuschieri, A., Dholakia, K., Prausnitz, M., Campbell, P.: Membrane disruption by optically controlled microbubble cavitation. Nat. Phys. 1, 107 (2005)
Zhou, Y., Yang, K., Cui, J., Ye, J.Y., Deng, C.X.: Controlled permeation of cell membrane by single bubble acoustic cavitation. J. Control. Release 157, 103–111 (2012)
Caskey, C.F., Stieger, S.M., Qin, S., Dayton, P.A., Ferrara, K.W.: Direct observations of ultrasound microbubble contrast agent interaction with the microvessel wall. J. Acoustic. Soc. Am. 122, 1191–1200 (2007)
Chen, H., Brayman, A.A., Evan, A.P., Matula, T.J.: Preliminary observations on the spatial correlation between short-burst microbubble oscillations and vascular bioeffects. Ultrasound Med. Biol. 38, 2151–2162 (2012)
Dromi, S., Frenkel, V., Luk, A., Traughber, B., Angstadt, M., Bur, M., Poff, J., Xie, J., Libutti, S.K., Wood, B.J.: Pulsed-high intensity focused ultrasound and low temperature-sensitive liposomes for enhanced targeted drug delivery and antitumor effect. Clin. Cancer Res. 13, 2722–2727 (2007)
Watson, K.D., Lai, C.Y., Qin, S., Kruse, D.E., Lin, Y.C., Seo, J.W., Cardiff, R.D., Mahakian, L.M., Beegle, J., Ingham, E.S., Curry, F.R., Reed, R.K., Ferrara, K.W.: Ultrasound increases nanoparticle delivery by reducing intratumoral pressure and increasing transport in epithelial and epithelial-mesenchymal transition tumors. Cancer Res. 72, 1485–1493 (2012)
Fujii, H., Li, S.H., Wu, J., Miyagi, Y., Yau, T.M., Rakowski, H., Egashira, K., Guo, J., Weisel, R.D., Li, R.K.: Repeated and targeted transfer of angiogenic plasmids into the infarcted rat heart via ultrasound targeted microbubble destruction enhances cardiac repair. Eur. Heart J. 32, 2075–2084 (2011)
Bekeredjian, R., Chen, S., Frenkel, P.A., Grayburn, P.A., Shohet, R.V.: Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart. Circulation 108, 1022–1026 (2003)
Chertok, B., Langer, R., Anderson, D.G.: Spatial control of gene expression by nanocarriers using heparin masking and ultrasound-targeted microbubble destruction. ACS Nano 10, 7267–7278 (2016)
Zhu, F., Jiang, Y., Luo, F., Li, P.: Effectiveness of localized ultrasound-targeted microbubble destruction with doxorubicin liposomes in H22 mouse hepatocellular carcinoma model. J. Drug Target. 23, 323–334 (2015)
Aryal, M., Vykhodtseva, N., Zhang, Y.Z., Park, J., Mcdannold, N.: Multiple treatments with liposomal doxorubicin and ultrasound-induced disruption of blood-tumor and blood-brain barriers improves outcomes in a rat glioma model. J. Control. Release 169, 103–111 (2013)
Smith, B.R., Gambhir, S.S.: Nanomaterials for in vivo imaging. Chem. Rev. 117, 901 (2017)
Sevick-Muraca, E.M., Houston, J.P., Gurfinkel, M.: Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents. Curr. Opin. Chem. Biol. 6, 642 (2002)
Weissleder, R., Mahmood, U.: Molecular imaging. Radiology 219, 316 (2001)
Ntziachristos, V., Ripoll, J., Wang, L.V., Weissleder, R.: Looking and listening to light: the evolution of whole-body photonic imaging. Nat. Biotechnol. 23, 313 (2005)
Wang, J., Mi, P., Lin, G., Wang, Y.X., Liu, G., Chen, X.: Imaging guided delivery of RNAi for anticancer treatment. Adv. Drug Deliv. Rev. 104, 44–60 (2016)
Zanzonico, P.: Noninvasive imaging for supporting basic research. In: Small Animal Imaging. Springer, Berlin (2011)
Wu, X., Wu, M., Zhao, J.X.: Recent development of silica nanoparticles as delivery vectors for cancer imaging and therapy. Nanomed. Nanotech. Biol. Med. 10, 297–312 (2014)
Zhao, X., Tapec-Dytioco, R., Tan, W.: Ultrasensitive DNA detection using highly fluorescent bioconjugated nanoparticles. J. Am. Chem. Soc. 125, 11474 (2003)
Herr, J.K., Smith, J.E., Medley, C.D., Shangguan, D., Tan, W.: Aptamer-conjugated nanoparticles for selective collection and detection of cancer cells. Anal. Chem. 78, 2918–2924 (2006)
Bamrungsap, S., Chen, T., Shukoor, M.I., Chen, Z., Sefah, K., Chen, Y., Tan, W.: Pattern recognition of cancer cells using aptamer-conjugated magnetic nanoparticles. ACS Nano 6, 3974–3981 (2012)
Lu, J., Liong, M., Li, Z., Zink, J.I., Tamanoi, F.: Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals. Small 6, 1794–1805 (2010)
Jun, B.H., Hwang, D.W., Jung, H.S., Jang, J., Kim, H., Kang, H.: Ultrasensitive, biocompatible, quantum-dot-embedded silica nanoparticles for bioimaging. Adv. Func. Mater. 22, 1843–1849 (2012)
Wilhelm, M., Zhao, C.L., Wang, Y., Xu, R., Winnik, M.A., Mura, J.L.: Poly (styrene-ethylene oxide) block copolymer micelle formation in water: a fluorescence probe study. Macromolecules 24, 1033–1040 (1991)
Yan, K., Li, H., Li, P., Zhu, H., Shen, J., Yi, C.: Self-assembled magnetic fluorescent polymeric micelles for magnetic resonance and optical imaging. Biomaterials 35, 344–355 (2014)
Li, C., Xia, J., Wei, X., Yan, H., Si, Z., Ju, S.: Ph-activated near-infrared fluorescence nanoprobe imaging tumors by sensing the acidic microenvironment. Adv. Func. Mater. 20, 2222–2230 (2010)
Wang, W., Cheng, D., Gong, F., Miao, X., Shuai, X.: Design of multifunctional micelle for tumor-targeted intracellular drug release and fluorescent imaging. Adv. Mater. 24, 115–120 (2012)
Auzel, F.: Upconversion and anti-stokes processes with f- and d-ions in solids. Chem. Rev. 104, 139–173 (2004)
Gu, Z., Yan, L., Tian, G., Li, S., Chai, Z., Zhao, Y.: Recent advances in design and fabrication of upconversion nanoparticles and their safe theranostic applications. Adv. Mater. 25, 3758–3779 (2013)
Liu, Y., Tu, D., Zhu, H., Chen, X.: Lanthanide-doped luminescent nanoprobes: controlled synthesis, optical spectroscopy, and bioapplications. Chem. Soc. Rev. 42, 6924 (2013)
Cheng, L., Yang, K., Li, Y., Chen, J., Wang, C., Shao, M., Lee, S.T., Liu, Z.: Facile preparation of multifunctional upconversion nanoprobes for multimodal imaging and dual-targeted photothermal therapy. Angew. Chem. Int. Ed. 50, 7385–7390 (2011)
Cheng, L., Wang, C., Liu, Z.: Upconversion nanoparticles and their composite nanostructures for biomedical imaging and cancer therapy. Nanoscale 5, 23–37 (2012)
Ehlert, O., Thomann, R., Darbandi, M., Nann, T.: A four-color colloidal multiplexing nanoparticle system. ACS Nano 2, 120 (2008)
Liu, Q., Yang, T., Feng, W., Li, F.: Blue-emissive upconversion nanoparticles for low-power-excited bioimaging in vivo. J. Am. Chem. Soc. 134, 5390 (2012)
Liu, Q., Yin, B., Yang, T., Yang, Y., Shen, Z., Yao, P.: A general strategy for biocompatible, high-effective upconversion nanocapsules based on triplet-triplet annihilation. J. Am. Chem. Soc. 135, 5029 (2013)
Xiong, L.Q., Chen, Z.G., Yu, M.X., Li, F.Y., Liu, C., Huang, C.H.: Synthesis, characterization, and in vivo targeted imaging of amine-functionalized rare-earth up-converting nanophosphors. Biomaterials 30, 5592–5600 (2009)
Xiong, L., Chen, Z., Tian, Q., Cao, T., Xu, C., Li, F.: High contrast upconversion luminescence targeted imaging in vivo using peptide-labeled nanophosphors. Anal. Chem. 81, 8687–8694 (2009)
Wang, M., Mi, C.C., Wang, W.X., Liu, C.H., Wu, Y.F., Xu, Z.R.: Immunolabeling and nir-excited fluorescent imaging of HeLa cells by using NaYF4: Yb, Er upconversion nanoparticles. ACS Nano 3, 1580 (2009)
Cheng, L., Yang, K., Zhang, S., Shao, M., Lee, S., Liu, Z.: Highly-sensitive multiplexed in vivo, imaging using pegylated upconversion nanoparticles. Nano Res. 3, 722–732 (2010)
Liang, C., Wang, C., Ma, X., Wang, Q., Cheng, Y., Wang, H.: Multifunctional upconversion nanoparticles for dual-modal imaging-guided stem cell therapy under remote magnetic control. Adv. Func. Mater. 23, 272–280 (2013)
Zhao, L., Kutikov, A., Shen, J., Duan, C., Song, J., Han, G.: Stem cell labeling using polyethylenimine conjugated (α-naybf4:tm3 +)/caf2 upconversion nanoparticles. Theranostics 3, 249–257 (2013)
Min, Y., Li, J., Liu, F., Padmanabhan, P., Yeow, E., Xing, B.: Recent advance of biological molecular imaging based on lanthanide-doped upconversion-luminescent nanomaterials. Nanomaterials 4, 129–154 (2014)
Phelps, M.E., Hoffman, E.J., Mullani, N.A., Ter-Pogossian, M.M.: Application of annihilation coincidence detection to transaxial reconstruction tomography. J. Nuc. Med. 16, 210 (1975)
Terpogossian, M.M., Phelps, M.E., Hoffman, E.J., Mullani, N.A.: A positron-emission transaxial tomograph for nuclear imaging. Radiology 114, 89 (1975)
Soret, M., Bacharach, S.L., Buvat, I.: Partial-volume effect in PET tumor imaging. J. Nuc. Med. 48, 932–945 (2007)
Cascini, G.L., Avallone, A., Delrio, P., Guida, C., Tatangelo, F., Marone, P.: 18F-FDG pet is an early predictor of pathologic tumor response to preoperative radiochemotherapy in locally advanced rectal cancer. J. Nuc. Med. 47, 1241 (2006)
Kwee, R.M.: Prediction of tumor response to neoadjuvant therapy in patients with esophageal cancer with use of 18F-FDG PET: a systematic review. Radiology 254, 707–717 (2010)
Phelps, M.E.: Positron Emission Tomography Clinical Brain Imaging: Principles and Applications. F.A. Davis Company, Philadelphia (1992)
Sharma, V., Luker, G.D., Piwnicaworms, D.: Molecular imaging of gene expression and protein function in vivo with PET and SPECT. J. Magn. Reson. Imaging 16, 336–351 (2002)
Kirsch, M., Wannez, S., Thibaut, A., Laureys, S., Brichant, J.F., Bonhomme, V.: Positron emission tomography: basic principles, new applications, and studies under anesthesia. Int. Anesthesiol. Clin. 54, 109 (2016)
Zanzonico, P.: Positron emission tomography: a review of basic principles, scanner design and performance, and current systems. Semin. Nuc. Med. 34, 87 (2004)
Schwinger, J.: Source theory analysis of electron-positron annihilation experiments. Proc. Nat. Acad. Sci. USA 72, 4725–4728 (1975)
Mirabello, V., Calatayud, D.G., Arrowsmith, R.L., Ge, H., Pascu, S.I.: Metallic nanoparticles as synthetic building blocks for cancer diagnostics: from materials design to molecular imaging applications. J. Mater. Chem. B 3, 5657–5672 (2015)
Kuhl, D.E., Edwards, R.Q.: Image separation radioisotope scanning. Radiology 80, 653–666 (1963)
Vogel, R.A., Kirch, D., Lefree, M., Steele, P.: A new method of multiplanar emission tomography using a seven pinhole collimator and an anger scintillation camera. J. Nuc. Med. 19, 648–654 (1978)
Groch, M.W., Ali, A., Erwin, W.D., Fordham, E.F.: Focal plane dual-head longitudinal tomography. In: Ahluwalia, B.D. (ed.) Tomographic Methods in Nuclear Medicine: Physical Principles, Instruments and Clinical Applications, pp. 123–150. FL. CRC Press, Boca Raton (1989)
Murphy, P.H., Thompson, W.L., Moore, M.L., Burdine, J.A.: Radionuclide computed tomography of the body using routine radiopharmaceuticals. I. System characterization. J. Nuc. Med. 20, 102–107 (1979)
Keidar, Z., Israel, O., Krausz, Y.: SPECT/CT in tumor imaging: technical aspects and clinical applications. Semin. Nuc. Med. 33, 205 (2003)
Heiba, S.I., Kolker, D., Mocherla, B., Kapoor, K., Jiang, M., Son, H.: The optimized evaluation of diabetic foot infection by dual isotope SPECT/CT imaging protocol. J. Foot Ankle Surg. 49, 529–536 (2010)
Spanu, A., Solinas, M.F., Sanna, D., Nuvoli, S., Madeddu, G.: 131I SPECT/CT in the follow-up of differentiated thyroid carcinoma: incremental value versus planar imaging. J. Nuc. Med. 50, 184 (2009)
Mandl, S., Schimmelpfennig, C., Edinger, M., Negrin, R.S., Contag, C.H.: Understanding immune cell trafficking patterns via in vivo bioluminescence imaging. J. Cell. Biochem. Suppl. 39, 239 (2002)
Lu, F.M., Yuan, Z.: PET/SPECT molecular imaging in clinical neuroscience: recent advances in the investigation of CNS diseases. Quant. Imaging Med. Surg. 5, 433–447 (2015)
Pimlott, S.L., Sutherland, A.: Molecular tracers for the PET and SPECT imaging of disease. Chem. Soc. Rev. 40, 149–162 (2011)
Kannan, S., Saadani-Makki, F., Balakrishnan, B.: Magnitude of [11C] PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure. Dev. Neurosci. (Basel) 33, 231–240 (2011)
Chung, Y.A., Jh, O., Kim, J.Y.: Hypoperfusion and ischemia in cerebral amyloid angiopathy documented by 99mTc-ECD brain perfusion SPECT. J. Nuc. Med. 2009, 50 (1969)
Hyafil, F., Cornily, J.C., Feig, J.E., Gordon, R., Vucic, E., Amirbekian, V.: Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography. Nat. Med. 13, 636–641 (2007)
Jakhmola, A., Anton, N., Vandamme, T.F.: Inorganic nanoparticles based contrast agents for X-ray computed tomography. Adv. Healthcare Mater. 1, 413–431 (2012)
Archana, R., Sushma, P., Ashok, L., Sujatha, G.P.: Cone-beam computed tomography: small cone big scoop! J. Dent. Oral Med. 3, 501 (2010)
Pysz, M.A., Gambhir, S.S., Willmann, J.K.: Molecular imaging: current status and emerging strategies. Clin. Radiol. 65, 500–516 (2010)
Chung, Y.E., Hyung, W.J., Kweon, S., Lim, S.J., Lee, M.H., Kim, H., Myoung, S., Lim, J.S.: Feasibility of interstitial CT lymphography using optimized iodized oil emulsion in rats. Invest. Radiol. 45, 142–148 (2010)
Kweon, S.J., Lee, H.J., Suh, J.S., Lim, J.S., Lim, S.J.: Liposomes coloaded with iopamidol/lipiodol as a RES-targeted contrast agent for computed tomography imaging. Pharm. Res. 27, 1408–1415 (2010)
Yin, Q., Yap, F.Y., Yin, L., Ma, L., Zhou, Q., Dobrucki, L.W., Fan, T.M., Gaba, R.C., Cheng, J.: Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging. J. Am. Chem. Soc. 135, 13620–13623 (2013)
Rabin, O., Maneul, P.J., Grimm, J., Wojtkiewicz, G., Weissleder, R.: An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat. Mater. 5, 118–122 (2006)
Pan, D., Schirra, C.O., Senpan, A., Schmieder, A.H., Stacy, A.J., Roessl, E., Thran, A., Wickline, S.A., Proska, R., Lanza, G.M.: An early investigation of ytterbium nanocolloids for selective and quantitative “multicolor” spectral CT imaging. ACS Nano 6, 3364–3370 (2012)
Jakhmola, A., Anton, N., Anton, H., Messaddeq, N., Hallouard, F., Klymchenko, A., Mely, Y., Vandamme, T.F.: Poly-ε-caprolactone tungsten oxide nanoparticles as a contrast agent for X-ray computed tomography. Biomaterials 35, 2981–2986 (2014)
Yamanaka, M., Smith, N.I., Fujita, K.: Introduction to super-resolution microscopy. Microscopy 63, 177–192 (2014)
Kobayashi, H., Longmire, M.R., Ogawa, M., Choyke, P.L.: Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals. Chem. Soc. Rev. 40, 4626–4648 (2011)
Cai, W.B., Chen, X.Y.: Multimodality molecular imaging of tumor angiogenesis. J. Nuc. Med. 49, 113S–128S (2008)
Olson, E.S., Jiang, T., Aguilera, T.A., Nguyen, Q.T., Ellies, L.G., Scadeng, M.: Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and mr imaging of proteases. Proc. Nat. Acad. Sci. USA 107, 4311–4316 (2010)
Savic, R., Luo, L., Eisenberg, L., Maysinger, D.: Micellar nanocontainers distribute to defined cytoplasmic organelles. Science 300, 615–618 (2003)
Miura, Y., Tsuji, A.B., Sugyo, A., Sudo, H., Aoki, I., Inubushi, M.: Polymeric micelle platform for multimodal tomographic imaging to detect scirrhous gastric cancer. ACS Biomater. Sci. Eng. 1, 1067–1076 (2015)
Seulki, L., Chen, X.: Dual-modality probes for in vivo molecular imaging. Mol. Imaging 8, 87–100 (2009)
Louie, A.Y.: Multimodality imaging probes: design and challenges. Chem. Rev. 110, 3146–3195 (2010)
Glaus, C., Rossin, R., Welch, M.J., Bao, G.: In vivo evaluation of 64Cu-labeled magnetic nanoparticles as a dual-modality PET/MR imaging agent. Bioconjugate Chem. 21, 715 (2010)
Sun, I.C., Eun, D.K., Na, J.H., Lee, S., Kim, I.J., Youn, I.C.: Heparin-coated gold nanoparticles for liver-specific CT imaging. Chemistry 15, 13341–13347 (2009)
Qian, X.M., Nie, S.M.: Single-molecule and single-nanoparticle sers: from fundamental mechanisms to biomedical applications. Chem. Soc. Rev. 37, 912–920 (2008)
Eustis, S., Elsayed, M.A.: Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes. Chem. Soc. Rev. 35, 209 (2006)
Dreaden, E.C., Mackey, M.A., Huang, X., Kang, B., Elsayed, M.A.: Beating cancer in multiple ways using nanogold. Chem. Soc. Rev. 40, 3391 (2011)
Song, Y., Xu, X., Macrenaris, K.W., Zhang, X.Q., Mirkin, C.A., Meade, T.J.: Multimodal gadolinium-enriched dna gold nanoparticle conjugates for cellular imaging. Angew. Chem. 48, 9143 (2009)
Sun, H., Yuan, Q., Zhang, B., Ai, K., Zhang, P., Lu, L.: Gd(III) functionalized gold nanorods for multimodal imaging applications. Nanoscale 3, 1990–1996 (2011)
Sun, M., Peng, D., Hao, H., Hu, J., Wang, D., Wang, K.: Thermally triggered in situ assembly of gold nanoparticles for cancer multimodal imaging and photothermal therapy. ACS Appl. Mater. Interfaces. 9, 10453 (2017)
Ji, S.R., Liu, C., Zhang, B., Yang, F., Xu, J., Long, J.: Carbon nanotubes in cancer diagnosis and therapy. Biochim. Biophys. Acta 1806, 29 (2010)
Chen, B., Zhang, H., Zhai, C., Du, N., Sun, C., Xue, J.: Carbon nanotube-based magnetic-fluorescent nanohybrids as highly efficient contrast agents for multimodal cellular imaging. J. Mater. Chem. 20, 9895–9902 (2010)
Chen, B., Zhang, H., Du, N., Zhang, B., Wu, Y., Shi, D.: Magnetic-fluorescent nanohybrids of carbon nanotubes coated with Eu, Gd Co-doped LaF3 as a multimodal imaging probe. J. Colloid Interface Sci. 367, 61 (2012)
Yang, K., Hu, L., Ma, X., Ye, S., Cheng, L., Shi, X.: Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles. Adv. Mater. 2012, 24 (1868)
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Yu, F. et al. (2018). Biomedical Applications of Functional Micro-/Nanoimaging Probes. In: Liu, Z. (eds) Advances in Functional Micro-/Nanoimaging Probes. Engineering Materials. Springer, Singapore. https://doi.org/10.1007/978-981-10-4804-3_3
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