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Exosomes in Cardiovascular Diseases pp 207–219Cite as

Cardiac Progenitor-Cell Derived Exosomes as Cell-Free Therapeutic for Cardiac Repair

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 998))

Abstract

Cardiac progenitor cells (CPCs) have emerged as potential therapy to improve cardiac repair and prevent damage in cardiac diseases. CPCs are a promising cell source for cardiac therapy as they can generate all cardiovascular lineages in vitro and in vivo. Originating from the heart itself, CPCs may be destined to activate endogenous repair mechanisms. These CPCs release paracrine molecules that are able to stimulate cardiac repair mechanisms, including stimulation of vessel formation and inhibition of cardiomyocyte apoptosis. In addition to proteins and growth factors, CPCs release extracellular membrane vesicles, such as exosomes, which have gained increasing interest in recent years. Exosomal-derived miRNAs have been indicated to play an important role in these processes. Hereby, CPC exosomes can be considered as potential off-the-shelf therapeutics, as they are able to stimulate the regenerative capacity of the heart by increasing vessel density and lowering apoptosis of cardiomyocytes.

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Acknowledgements

EAM is funded by the Project SMARTCARE-II of the BioMedical Materials institute, co-funded by the ZonMw-TAS program (#116002016), the Netherlands Organization for Health Research and Development, the Dutch Ministry of Economic Affairs, Agriculture and Innovation and the Netherlands Cardio Vascular Research Initiative (CVON): the Dutch Heart Foundation, Royal Netherlands Academy of Sciences, and the Dutch Federations of University Medical Centers.JS received a Horizon 2020 ERC-2016-COG grant, called EVICARE (725229).

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Authors and Affiliations

  1. Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3584CX, The Netherlands

    E. A. Mol & J. P. G. Sluijter

  2. Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands

    M. J. Goumans

  3. UMC Utrecht Regenerative Medicine Center, University Medical Center, Utrecht, 3584CT, The Netherlands

    J. P. G. Sluijter

  4. Netherlands Heart Institute, Utrecht, 3584CX, The Netherlands

    J. P. G. Sluijter

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  1. E. A. Mol
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Correspondence to J. P. G. Sluijter .

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Editors and Affiliations

  1. Shanghai University , Shanghai, China

    Junjie Xiao

  2. Victor Babeş National Institute of Patho , Bucharest, Romania

    Sanda Cretoiu

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Mol, E.A., Goumans, M.J., Sluijter, J.P.G. (2017). Cardiac Progenitor-Cell Derived Exosomes as Cell-Free Therapeutic for Cardiac Repair. In: Xiao, J., Cretoiu, S. (eds) Exosomes in Cardiovascular Diseases. Advances in Experimental Medicine and Biology, vol 998. Springer, Singapore. https://doi.org/10.1007/978-981-10-4397-0_14

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