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Development of New Tri-block Copolymers for Pharmaceutical Applications

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6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6) (BME 2017)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 63))

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Abstract

We have developed several tri-block copolymers for nanomedicines. First, a biocompatible tri-block copolymer, poly(ethylene glycol)-block-poly(lactic acid)-block-poly(ethylene glycol) (PEG-PLA-PEG) was synthesized by simple approach without toxic linker to escalate therapeutic efficacy of anticancer agent by enhanced targeting to metastasized breast cancers. Secondly, a poly(ethylene glycol)-poly(lactic acid)-poly(ethylene imine) triblock copolymer (PEI-PLA-PEG) and a poly(aspartic acid) (P(Asp)) homopolymer were synthesized for polyelectrolyte inonmer complexes. The synthesized tri-block copolymers formed small, highly stable spherical aggregates. The doxorubicin loaded nanovehicles prepared from the tri-block copolymers accumulated the tumor sites in animal model. The nanovehicles could have considerable potential for pharmaceutical applications.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2014R1A2A1A11050094 and 2015R1A5A1008958).

Author information

Authors and Affiliations

  1. College of Pharmacy, Chung-Ang University, 221 Heukseok dong, Dongjak-gu, Seoul, 155-756, Republic of Korea

    Kyung Taek Oh

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  1. Kyung Taek Oh
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Correspondence to Kyung Taek Oh .

Editor information

Editors and Affiliations

  1. Biomedical Engineering Department, Vietnam National University, Ho Chi Minh , Ho Chi Minh City, Vietnam

    Toi Vo Van

  2. Department of Biomedical Engineering, Vietnam National University, Ho Chi Minh Department of Biomedical Engineering, Ho Chi Minh City, Vietnam

    Thanh An Nguyen Le

  3. Biomedical Engineering Department, Vietnam National University, Ho Chi Minh Biomedical Engineering Department, Ho Chi Minh City, Vietnam

    Thang Nguyen Duc

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Oh, K.T. (2018). Development of New Tri-block Copolymers for Pharmaceutical Applications. In: Vo Van, T., Nguyen Le, T., Nguyen Duc, T. (eds) 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6) . BME 2017. IFMBE Proceedings, vol 63. Springer, Singapore. https://doi.org/10.1007/978-981-10-4361-1_133

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  • DOI: https://doi.org/10.1007/978-981-10-4361-1_133

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4360-4

  • Online ISBN: 978-981-10-4361-1

  • eBook Packages: EngineeringEngineering (R0)

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