Abstract
Respiratory tract diseases are a common cause of medical consultation. Indeed, most of this patients need an adequate treatment to improve their airway conditions. In order to understand how the airflow works through the lower airway and how disease condition may affect it, this paper presents an airflow simulation based on a three dimensional model from a real human airway constructed from a Computed Tomography scan.
Methodology used to perform the simulation, include the implementation of Materialise’s medical image software MIMICS® (v. 18.0), in order to segment the lower airway using region based segmentation procedures. Moreover, a computational fluid dynamic simulation was carried out by using the finite element software Comsol® (v. 5.2); to this end, this paper shows a comprehensive workflow integrating both software to obtain a realistic airflow simulation through the lower airway.
Velocity and pressure profiles are presented to assess the effectiveness of the simulation, showing a parabolic non-compressive flow and high pressure in complex anatomical geometric areas, validating the expected physiologic behavior.
This is a preview of subscription content, log in via an institution to check access.
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Lewis David J., McKevitt Tom P.. Respiratory System in Toxicologic Pathology: Nonclinical Safety Assessment (Sahota Pritam S., Popp James A., Hardisty Jerry F., Gopinath Chirukandath. , eds.)ch. 11Boca Raton, FL: CRC Press Tylor & Francis Group 2013.
Johari Nasrul Hadi, Osman Kahar, Helmi Nor Harris N, Abdul Kadir Mohammed a Rafiq. Comparative analysis of realistic CT-scan and simplified human airway models in airflow simulation. Computer methods in biomechanics and biomedical engineering. 2013;5842:37–41.
Yu Chi, Chen Shu-hua, Wang Gang, Wang Ying. Numerical Analysis of Flow Characteristics for the Normal Human Upper Airway Biomedical Engineering: Applications, Basis and Communications. 2016;28:1–12.
Rahiminejad Mohammad, Haghighi Abdalrahman, Dastan Alireza, Abouali Omid, Farid Mehrdad, Ahmadi Goodarz. Computer simulations of pressure and velocity fields in a human upper airway during sneezing Computers in Biology and Medicine. 2016;71:115–127.
Scheinherr Adam, Bailly Lucie, Boiron Olivier, et al. Realistic glottal motion and airflow rate during human breathing Medical Engineering and Physics. 2015;37:829–839.
Elcner Jakub, Lizal Frantisek, Jedelsky Jan, Jicha Miroslav, Chovancova Michaela. Numerical investigation of inspiratory airflow in a realistic model of the human tracheobronchial airways and a comparison with experimental results Biomechanics and Modeling in Mechanobiology. 2016;15:447–469.
Cisonni Julien, Lucey Anthony D., King Andrew J C, Islam Syed Mohammed Shamsul, Lewis Richard, Goonewardene Mithran S.. Numerical simulation of pharyngeal airflow applied to obstructive sleep apnea: effect of the nasal cavity in anatomically accurate airway models Medical and Biological Engineering and Computing. 2015;53:1129–1139.
Gokcan M Kursat, Gunaydinoglu Erkan, Kurtulus D Funda. Effect of glottic geometry on breathing: three-dimensional unsteady numerical simulation of respiration in a case with congenital glottic web. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2016.
Trabelsi O, Malve M, Mena Tobar A, Doblare M. Simulation of swallowing dysfunction and mechanical ventilation after a Montgomery T-tube insertion Comput Methods Biomech Biomed Engin. 2015;18:1596–1605.
Ruiz A. E., Arboleda D. C., Aristizabal J. K.. Non-rigid registration of airway region in computed tomography of ICU patient using B-splines in 3D-slicer Pan American Health Care Exchanges, PAHCE. 2015;2015-July:6968.
Longest P Worth, Azimi Mandana, Hindle Michael. Optimal Delivery of Aerosols to Infants During Mechanical Ventilation. Journal of aerosol medicine and pulmonary drug delivery. 2013;27:1–15.
Youn Ann Misun, Yoon Seok-hwa, Park Soo-yong. Failed intubation of an unanticipated postintubation tracheal stenosis Korean Journal of Anesthesiology. 2016:2–5.
Rahimi-Gorji M., Pourmehran O., Gorji-Bandpy M., Gorji T.B.. CFD simulation of airflow behavior and particle transport and deposition in different breathing conditions through the realistic model of human airways Journal of Molecular Liquids. 2015;209:121–133.
Calmet Hadrien, Gambaruto Alberto M., Bates Alister J., Vázquez Mariano, Houzeaux Guillaume, Doorly Denis J.. Large-scale CFD simulations of the transitional and turbulent regime for the large human airways during rapid inhalation Computers in Biology and Medicine. 2016;69:166–180.
Kongnuan S., Na-Thakuatung U., Pholuang J.. a Comparative of Analytical and Numerical Simulations for the Oscillating Airflow in a Human Oral Airway International Journal of Pure and Applied Mathematics. 2014;90:321–333.
Sarasaen Chompunuch, Bhongmakapat Thongchai, Hemtiwakorn Khaisang, Laothamatas Jiraporn, Pintavirooj Chuchart. Computational Fluid Dynamic (CFD) in Thai patient with Obstructive Sleep Apnea Syndrome (OSAS) - A case report: Comparative study between healthy and OSA subject 5th 2012 Biomedical Engineering International Conference, BMEiCON 2012. 2012:0–5.
Chase Michael. Simulation of Flow and Heat Transfer Through Packed Beds of Spheres Tech. Rep. AugustWorcester Polytechnic InstituteWorcester 2011.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Ruiz, A.E., Aristizábal, J.K. (2017). Three Dimensional Reconstruction and Airflow Simulation in a Realistic Model of the Human Respiratory Airways. In: Torres, I., Bustamante, J., Sierra, D. (eds) VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016. IFMBE Proceedings, vol 60. Springer, Singapore. https://doi.org/10.1007/978-981-10-4086-3_134
Download citation
DOI: https://doi.org/10.1007/978-981-10-4086-3_134
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-4085-6
Online ISBN: 978-981-10-4086-3
eBook Packages: EngineeringEngineering (R0)