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Balz-Schiemann Reaction

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Fluorination

Part of the book series: Synthetic Organofluorine Chemistry ((SYOC))

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Introduction

Aryl fluorides are important structural motifs in pharmaceuticals [21,22,3], and nearly 20% of 200 best-selling drugs in 2018 contain at least one (hetero)aryl fluoride motif [4]. The past decade has witnessed significant progress in the development of aromatic C-F bond formation, especially via transition metal-mediated or catalyzed processes [5]. However, among all the available methods, Balz-Schiemann reaction (Scheme 1) is one of the most widely used methods for large-scale industrial production of aryl fluorides due to ready availability of the starting materials [6].

Balz-Schiemann Reaction, Scheme 1
scheme 1 scheme 1

Balz-Schiemann reaction

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Authors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

    Chuanfa Ni, Bo Xing & Jinbo Hu

Authors
  1. Chuanfa Ni
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  2. Bo Xing
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  3. Jinbo Hu
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Correspondence to Jinbo Hu .

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Editors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

    Jinbo Hu

  2. Zhejiang Jiuzhou Pharmaceutical Co., Ltd, R&D Center, Taizhou, China

    Teruo Umemoto

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Ni, C., Xing, B., Hu, J. (2020). Balz-Schiemann Reaction. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-3896-9_59

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