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Transition Metal-Mediated Radical Fluorination for Preparing Alkyl Fluorides

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Fluorination

Part of the book series: Synthetic Organofluorine Chemistry ((SYOC))

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Introduction

Transition metals play a vital role in modern synthetic organic chemistry. Transition metal-mediated radical reactions have also been firmly established as an indispensable tool in organic synthesis. However, their importance in C(sp3)–F bond formations was not realized until Li et al. reported the silver-catalyzed decarboxylative fluorination of aliphatic carboxylic acids in 2012 [1]. Following Li’s pioneer work, several research groups reported a number of remarkable results in this area in the past 5 years. These efforts have significantly pushed forward the development of transition metal-mediated radical fluorination, which has now emerged as a powerful and versatile tool for the synthesis of alkyl fluorides. In this entry, these advancements will be discussed based on the types of transition metals employed.

Silver

In 2012, Li et al. reported the silver-catalyzed decarboxylative fluorination of aliphatic carboxylic acids in aqueous solution [1]. The reactions...

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Acknowledgments

This project was supported by the National Basic Research Program of China (973 Program) (Grant 2015CB931900), by the National Natural Science Foundation of China (Grants 21421002, 21472220, 21532008, and 21602239), and by the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant XDB20020000).

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Authors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry and Collaborative Innovation Center of Chemistry for Life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, People’s Republic of China

    Lin Zhu & Chaozhong Li

  2. School of Materials and Chemical Engineering, Ningbo University of Technology, Ningbo, People’s Republic of China

    Chaozhong Li

Authors
  1. Lin Zhu
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  2. Chaozhong Li
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Corresponding author

Correspondence to Chaozhong Li .

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Editors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

    Jinbo Hu

  2. Zhejiang Jiuzhou Pharmaceutical Co., Ltd, R&D Center, Taizhou, China

    Teruo Umemoto

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Zhu, L., Li, C. (2020). Transition Metal-Mediated Radical Fluorination for Preparing Alkyl Fluorides. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-3896-9_16

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