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Fluorination of Aryl-Alkenyl-Iodonium Salts for Preparing Alkenyl Fluorides

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Fluorination

Part of the book series: Synthetic Organofluorine Chemistry ((SYOC))

Brief Introduction

Alkenyl fluorides are important building blocks for constructing fluoroalkene moiety containing complex organic molecules, which may possess interesting biological activities and thus are particularly attractive to the pharmaceutical and agrochemical industries [6174,6175,3]. In addition, they can be used as monomers for polymerization and copolymerization to form fluoropolymers with certain special properties [6177,6178,6]. Numerous synthetic approaches have been developed to obtain selectively functionalized alkenyl fluorides which can be classified into five major categories based upon the organic reactions: (1) Horner-Wadsworth-Emmons, Horner-Wittig, Julia, Peterson, and Reformatsky-type olefination reactions, (2) hydrofluorination of alkynes, (3) electronic fluorination of alkenyl metals, (4) reductive elimination reaction of multi-halo compounds, and (5) various metal catalyzed cross-coupling reactions using fluoroalkenyl moiety containing synthons, etc. These...

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Author information

Authors and Affiliations

  1. Citigroup of Biomedical Imaging Center, Weill Cornell Medicine, New York, NY, USA

    Wenchao Qu

  2. Department of Discovery, Avid Radiopharmaceuticals, Philadelphia, PA, USA

    Ximin Li

Authors
  1. Wenchao Qu
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  2. Ximin Li
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Correspondence to Wenchao Qu .

Editor information

Editors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

    Jinbo Hu

  2. Zhejiang Jiuzhou Pharmaceutical Co., Ltd, R&D Center, Taizhou, China

    Teruo Umemoto

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Qu, W., Li, X. (2020). Fluorination of Aryl-Alkenyl-Iodonium Salts for Preparing Alkenyl Fluorides. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-3896-9_13

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