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Functional Salivary Gland Regeneration

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Organ Regeneration Based on Developmental Biology

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Abstract

Oral health and homeostasis are maintained by the functional interactions of many organs, including the salivary glands, teeth, and tongue. Salivary gland dysfunction leads to dry mouth diseases, such as dental caries, bacterial infection, swallowing dysfunction, and reduced quality of life. The current clinical therapies for dry mouth are temporary, and they cannot repair salivary gland dysfunction. Salivary gland regenerative therapy with tissue repair and whole salivary gland replacement is a novel organ regenerative therapy. To achieve the recovery of the salivary gland function, adult tissue stem cells may be used as a cell source for salivary gland tissue repair therapies. To attain the entire salivary gland replacement therapy, which represents the next-generation regenerative therapy, we developed a novel cell manipulation method that can regenerate the ectodermal organ germ. The bioengineered salivary gland germs successfully engrafted grew in the transplantation site, generating the correct structure. The bioengineered salivary glands were able to secrete saliva into the oral cavity and improve dry mouth symptoms. In this chapter, we describe the recent progress and developmental methods for salivary gland regeneration therapy.

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Acknowledgments

This work was partially supported by a Grant-in-Aid for Kiban (A) from the Ministry of Education, Culture, Sports, Science and Technology (no. 25242041). `by Organ Technologies Inc.

Conflict of Interest

M. Ogawa and T. Tsuji have no competing interests.

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Authors and Affiliations

  1. Organ Technologies Inc., Chiyoda-ku, Tokyo, 101-0048, Japan

    Miho Ogawa

  2. RIKEN Center for Developmental Biology, Kobe, Hyogo, 650-0047, Japan

    Miho Ogawa

  3. Laboratory for Organ Regeneration, RIKEN Center for Developmental Biology, 2-2-3, Minatojima-mimamimschi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan

    Takashi Tsuji

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  1. Miho Ogawa
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  2. Takashi Tsuji
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Correspondence to Takashi Tsuji .

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  1. Laboratory for Organ Regeneration, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan

    Takashi Tsuji

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Ogawa, M., Tsuji, T. (2017). Functional Salivary Gland Regeneration. In: Tsuji, T. (eds) Organ Regeneration Based on Developmental Biology. Springer, Singapore. https://doi.org/10.1007/978-981-10-3768-9_7

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