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RUNX Proteins in Development and Cancer pp 353–368Cite as

Runx Genes in Breast Cancer and the Mammary Lineage

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 962))

Abstract

A full understanding of RUNX gene function in different epithelial lineages has been thwarted by the lethal phenotypes observed when constitutively knocking out these mammalian genes. However temporal expression of the Runx genes throughout the different phases of mammary gland development is indicative of a functional role in this tissue. A few studies have emerged describing how these genes impact on the fate of mammary epithelial cells by regulating lineage differentiation and stem/progenitor cell potential, with implications for the transformed state. The importance of the RUNX/CBFβ core factor binding complex in breast cancer has very recently been highlighted with both RUNX1 and CBFβ appearing in a comprehensive gene list of predicted breast cancer driver mutations. Nonetheless, the evidence to date shows that the RUNX genes can have dualistic outputs with respect to promoting or constraining breast cancer phenotypes, and that this may be aligned to individual subtypes of the clinical disease. We take this opportunity to review the current literature on RUNX and CBFβ in the normal and neoplastic mammary lineage while appreciating that this is likely to be the tip of the iceberg in our knowledge.

Nicholas Rooney and Alessandra I. Riggio contributed equally to this work.

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Acknowledgements

We thank Laura McDonald and Nicola Ferrari for providing material used in Fig. 22.1; all in vivo work in the Blyth lab is ethically approved (University of Glasgow) and carried out under Home Office licence in accordance with the EU Directive 2010. We also thank Catherine Winchester and Jim Neil for helpful comments on the manuscript. The Blyth lab is core funded by Cancer Research UK (grant code A17196).

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Authors and Affiliations

  1. Beatson Institute for Cancer Research, Bearsden, Glasgow, G61 1BD, UK

    Nicholas Rooney, Alessandra I. Riggio & Karen Blyth

  2. Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK

    Daniel Mendoza-Villanueva & Paul Shore

  3. School of Veterinary Medicine, University of Glasgow, Bearsden, Glasgow, G61 1QH, UK

    Ewan R. Cameron

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  1. Nicholas Rooney
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  2. Alessandra I. Riggio
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  6. Karen Blyth
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Correspondence to Karen Blyth .

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Editors and Affiliations

  1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

    Yoram Groner

  2. Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

    Yoshiaki Ito

  3. Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA

    Paul Liu

  4. Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

    James C. Neil

  5. Department of Cell and Development Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Nancy A. Speck

  6. Mayo Clinic, Rochester, Minnesota, USA

    Andre van Wijnen

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Rooney, N., Riggio, A.I., Mendoza-Villanueva, D., Shore, P., Cameron, E.R., Blyth, K. (2017). Runx Genes in Breast Cancer and the Mammary Lineage. In: Groner, Y., Ito, Y., Liu, P., Neil, J., Speck, N., van Wijnen, A. (eds) RUNX Proteins in Development and Cancer. Advances in Experimental Medicine and Biology, vol 962. Springer, Singapore. https://doi.org/10.1007/978-981-10-3233-2_22

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