Abstract
The metabolism pattern changes obviously after severe burn injury, the primary pathological phenomena are energy consumption and catabolism increased significantly, and nutrients utilize barriers. Severe burned patients will lead to autophagy metabolism, continuous consumption, and progressive emaciation. If the pathological process can not effectively block, it will lead to organ damage, immune dysfunction, wound healing delay and other adverse outcomes. Therefore, hypermetabolism after burn is one of the leading cause of multiple organ dysfunction and even death. After many years research, although there is certain understanding of hypermetabolism mechanism, but it is difficult to fully explain the causes of the hypermetabolism after burn, up to now. At the same time, the therapeutic measures of regulating hypermetabolism are still not perfect, and obstacle to burn comprehensive treatment level continuous progress.
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Referrence
Herndon DN, Tompkins RG. Support of the metabolic response to burn injury. Lancet. 2004;363:1895–902.
Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE. Pathophysiologic response to severe burn injury. Ann Surg. 2008;248:387–401.
Graves C, Saffle J, Cochran A. Actual burn nutrition care practices: an update. J Burn Care Res. 2009;30:77–82.
Dickerson RN, Gervasio JM, Riley ML, Murrell JE, Hickerson WL. Accuracy of predictive methods to estimate resting energy expenditure of thermally-injured patients. JPEN. 2002;26:17–29.
Shields BA, Doty KA, Chung KK, Wade CE, Aden JK. Determination of resting energy expenditure after severe burn. J Burn Care Res. 2013;34:e22–8.
Wang S, Li A, Xie W. How to estimate the calorie requirements of burned patients: origin of the Third Military Medical University formula for assessing calorie needs of burned adults. Parenter Enteral Nutr. 1995;2:221–4.
William GC. What’s new in burns and metabolism. J Am Coll Surg. 2001;200:241–57.
Williams FN, Herndon DN, Jeschke MG. The hypermetabolic response to burn injury and interventions to modify this response. Clin Plastic Surg. 2009;36:583–96.
Williams FN, Jeschke MG, Chinkes ES, Suman OE, Branski LK, Herndon DN. Modulation of the hypermetabolic response to trauma: temperature, nutrition, and drugs. J Am Coll Surg. 2009;208:489–502.
Hart DW, Wolf SE, Chinkes DL, et al. Determinants of skeletal muscle catabolism after severe burn. Ann Surg. 2000;232:455–65.
Hart DW, Wolf SE, Mlcak R, et al. Persistence of muscle catabolism after severe burn. Surgery. 2000;128:312–9.
Cone JB. What’s new in general surgery: burns and metabolism. J Am Coll Surg. 2005;204:608–15.
Bishara S, Atiyeh AS, William A, Gunn AE, Saad AD. Metabolic implications of severe burn injuries and their management: a systematic review of the literature. World J Surg. 2008;1857–69.
Przkora R, Herndon DN, Finnerty CC, et al. Insulin attenuates the cytokine response in a burn wound infection model. Shock. 2007;27:205–8.
Peng X. How to evaluate the balance of energy requirements and expenditure correctly in severe burn patient. Chin J Burns. 2013;29:331–4.
Rousseau AF, Losser MR, Ichai C, Berger MM. ESPEN endorsed recommendations: nutritional therapy in major burns. Clin Nutr. 2013;32:497–502.
Berger M. Basics in clinical nutrition: nutritional support in burn patients. J Clin Nutr Metab. 2009;4:e308–12.
Ballian N, Rabiee A, Andersen D, Gibson RB. Glucose metabolism in burn patients: the role of insulin and other endocrine hormones. Burns. 2010;36:599–605.
Martindale RG, McClave SA, Vanek VW, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition. Crit Care Med. 2009;37:1757–62.
Taylo BE, McClave SA, Martindale RG, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically Ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). Crit Care Med. 2016;44:390–412.
Hall KL, Shahrokhi S, Jeschke MG. Enteral nutrition support in burn care: a review of current recommendations as instituted in the Ross Tilley Burn Centre. Nutrients. 2012;4:1554–65.
Rodriguez NA, Jeschke MG, Williams FN, et al. Nutrition in burns: Galveston contributions. JPEN J Parenter Enteral Nutr. 2011;35:704–14.
Masters B, Wood F. Nutrition support in burns–is there consistency in practice? J Burn Care Res. 2008;29:561–71.
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Peng, X. (2017). Metabolic Changes and Nutrition Therapy in Burn Patients. In: Fu, X., Liu, L. (eds) Advanced Trauma and Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-10-2425-2_11
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DOI: https://doi.org/10.1007/978-981-10-2425-2_11
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