Abstract
Stress and emotional stimuli that disturb the homeostasis of the brain are strongly implicated in the morbidity and mortality from several types of inflammatory diseases, asthma included. Stress contributes to the development of asthma, affects its course through provoking exacerbations and inhibiting response to treatment, and acts directly on pathogenic mechanisms in the airways. In children who already have asthma, stress operates via a two-way process. Having asthma in itself causes stress, giving rise to anxiety and depression. Anxiety and depression, in turn, impact on asthma through immune function and autonomic dysregulation.
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References
Andersson NW, Hansen MV, Larsen AD, Hougaard KS, Kolstad HA, Schlunssen V (2015) Prenatal maternal stress and atopic diseases in the child: a systemic review of observational human studies. Eur J Allergy Clin Immun 71:15–26. https://doi.org/10.1111/all.12762
Avcil S, Uysal P, Demir F, Erge D, Omurlu KI, Yenigun A (2018) Mothers’ emotional states and attitudes regarding their children with asthma. J Asthma 55:1–25. https://doi.org/10.1080/02770903.2018.1484130
Bahreinian S, Ball GDC, Colman I, Becker AB, Kozyrskyj AL (2011) Depression is more common in girls with non-atopic asthma. Chest 140:1138–1145. https://doi.org/10.1378/chest.11-0219
Bahreinian S, Ball GDC, Vander Leek TK, Colman I, McNeill BJ, Becker AB, Kozyrskyj AL (2013) Allostatic load biomarkers and asthma in adolescents. Am J Respir Crit Care Med 187:144–152. https://doi.org/10.1164/rcm.201201-0025OC
Bleil ME, Ramesh S, Miller BD, Wood BL (2000) The influence of parent-child relatedness on depressive symptoms in children with asthma: tests of moderator and mediator models. J Pediatr Psychol 25:481–491
Bose S, Chiu Y-HM, Hsu H-HL, DI Q, Rosa MJ, Lee A, Kloog I, Wilson A, Schwartz J, Wright RO, Cohen S, Coull BA, Wright RJ (2017) Prenatal nitrate exposure and childhood asthma: influence of maternal prenatal stress and fetal sex. Am J Respir Crit Care Med 196:1396–1403. https://doi.org/10.1164/rccm.201702-0421OC
Brunst KJ, Rosa MJ, Jara C, Lipton LR, Lee A, Coull BA, Wright RJ (2017) Impact of maternal lifetime interpersonal trauma on children’s asthma: mediation through maternal active asthma during pregnancy. Psychosom Med 79:91–100. https://doi.org/10.1097/PSY.0000000000000354
Calam R, Gregg L, Simpson B, Morris J, Woodcock A, Custovic A (2003) Childhood asthma, behavior problems, and family functioning. J Allergy Clin Immun 112:499–504. https://doi.org/10.1067/mai.2003.1639
Calam R, Gregg L, Goodman R (2005) Psychological adjustment and asthma in children and adolescents: the UK Nationwide Mental Health Survey. Psychosom Med 67:105–110
Celano MP (2006) Family processes in pediatric asthma. Curr Opin Ped 18:539–544
Chen E, Strunk RC, Tretheway A, Schreier HMC, Maharaj N, Miller CE (2011) Resilience in low-socioeconomic-status children with asthma: adaptation to stress. J Allergy Clin Immun 128:970–976. https://doi.org/10.1016/j.jaci.2011.06.040
Collins JE, Gill TK, Chittleborough CR, Martin AJ, Taylor AW, Winefield H (2008) Mental, emotional, and social problems among school children with asthma. J Asthma 45:489–493. https://doi.org/10.1080/02770900802074802
Dudeney J, Sharpe L, Jaffe A, Jones EB, Hunt C (2017) Anxiety in youth with asthma: a meta-analysis. Pediatr Pulmon 52:1121–1129. https://doi.org/10.1002/ppul.23689
Ekim A, Ocakci AF (2016) Caregiver burden in pediatric asthma: a systematic review. Health Sci J 10:1–7. https://doi.org/10.21767/1791-809X.1000476
Farrell AK, Slatcher RB, Tobin ET, Imami L, Wildman DE, Luca F, Zilioli S (2018) Socioeconomic status, family negative emotional climate, and anti-inflammatory gene expression among youth with asthma. Psychoneuroendocrinology 91:62–67
Feldman JM, Ortega AN, McQuaid EL, Canino G (2006) Comorbidity between asthma attacks and internalizing disorders among Puerto Rican children at one-year follow-up. Psychosomatics 47:333–339. https://doi.org/10.1176/appi.psy.47.4.333
Flanigan C, Sheikh A, DunnGalvin A, Brew BK, Almqvist C, NwaruBI (2018) Prenatal maternal psychosocial stress and offspring’s asthma and allergic disease: a systemic review and meta-analysis. Clin Exp Allergy 48:403–414. https://doi.org/10.1111/cea.13091
Goodwin RD, Pine DS, Hoven CW (2003) Asthma and panic attacks among youth in the community. J Asthma 40:139–145. https://doi.org/10.1081/JAS-120017984
Halterman JS, Conn KM, Forbes-Jones E, Fagnano M, Hightower AD, Szilagyi PG (2006) Behavior problems among inner-city children with asthma: findings from a community-based sample. Pediatrics 117: e192–e199. https://doi.org/10.1542/peds.2005-1140
Hermans J, Florin I, Dietrich M, Rieger C, Halweg K (1989) Maternal criticism, mother-child interaction, and bronchial asthma. J Psychosom Res 33:469–476
Jemerin JM, Boyce WT (1992) Cardiovascular markers of biobehavioral reactivity. Devel Behav Pediatr 13:46–49
Kaugars AS, Klinnert MD, Bender BG (2004) Family influences on pediatric asthma. J Pediatr Psychol 29:475–491. https://doi.org/10.1093/jpepsy/jsh051
Kim DH, Yoo IY (2007) Factors associated with depression and resilience in asthmatic children. J Asthma 44:423–427. https://doi.org/10.1080/02770900701421823
Klinnert MD, McQuaid EL, McCormic D, Adinoff AD, Bryant NE (2000) A multimethod assessment of behavioral and emotional adjustment in children with asthma. J Pediatr Psychol 25:35–46
Klinnert MD, Nelson HS, Price MR, Adinoff AD, Leung DYM, Mrazek DA (2001) Onset and persistence of childhood asthma: predictors from infancy. Pediatrics 108:69–76. https://doi.org/10.1542/peds.108.4.e69
Lee A, Wright RJ (2016) Prenatal stress and childhood asthma risk: taking a broader view. Eur Respir J 47:406–409. https://doi.org/10.1183/13993003.01921-2015
Lim J, Wood BL, Miller BD, Simmens SJ (2011) Effects of paternal and maternal depressive symptoms on child internalizing symptoms and asthma disease activity: mediation by interparental negativity and parenting. J Fam Psychol 25:137–146. https://doi.org/10.1037/a0022452
Miller G, Chen E (2007) Unfavorable socioeconomic conditions in early life presage expression of proinflammatory phenotype in adolescence. Psychosom Med 69:402–409. https://doi.org/10.1097/PSY.0b013e318068fcf9
Miller GE, Chen E, Fok AK, Walker H, Lim A, Nicholls EF, Cole S, Kobor MS (2009) Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. PNAS 106:14716–14721. https://doi.org/10.1073/pnas.0902971106
Miller GE, Brody GH, Yu T, Chen E (2014) A family-oriented psychosocial intervention reduces inflammation in low-SES African American youth. PNAS 111:11287–11292. https://doi.org/10.1073/pnas.1406578111
Oberlander TF, Weinberg J, Papsdorf M, Grunau R, Misri S, Devlin AM (2008) Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics 3–2:97–106
Ohno I (2017) Neuropsychiatry phenotype in asthma: psychological stress-induced alterations of the neuroendocrine-immune system in allergic airway inflammation. Allergology International 66:S2–S8. https://doi.org/10.1016/j.alit.2017.06.005
Pateraki E, Morris PG (2018) Effectiveness of cognitive behavioural therapy in reducing anxiety in adults and children with asthma: a systematic review. J Asthma 55:532–554. https://doi.org/10.1080/02770903.2017.1350967
Puranic S, Forno E, Bush A, Caledón JC (2017) Predicting severe asthma exacerbations in children. Am J Respir Crit Care Med 195:854–859. https://doi.org/10.1164/rccm.201606-1213PP
Radhakrishnan D, Shariff SZ, To T (2018) The influence of prenatal mental health service use on the incidence of childhood asthma: a population-based cohort study. J Asthma April 25:1–35. https://doi.org/10.1080/02770903.2018.1466313
Ramratnam SK, Visness CM, Jaffee KF, Bloomberg GR, Kattan M, Sandel MT, Wood RA, Gern JE, Wright RJ (2017) Relationships among maternal stress and depression, Type 2 responses, and recurrent wheezing at age 3 years in low-income urban families. Am J Respir Crit Care Med 195:674–681. https://doi.org/10.1164/rccm.201602-0272OC
Rhee H, McQuillan B, Chen D-G, Atis S (2017) Perceptions about interpersonal relationships and school environment among middle school students with asthma. J Asthma 54:905–910. https://doi.org/10.1080/02770903.2016.1277540
Rioseco A, Serrano C, Celedón JC, Padilla O, Puschel K, Castro-Rodriguez JA (2017) Caregiver’s depressive symptoms and asthma control in children from an underserved community. J Asthma 54:1059–1064. https://doi.org/10.1080/02770903.2017.1292281
Rodriguez EM, Kumar H, Alba-Suarez J, Sánchez-Johnsen L (2017) Parental coping, depressive symptoms, and children’s asthma control and school attendance in low-income, racially, and ethnically diverse urban families. J Asthma 54:833–841. https://doi.org/10.1080/02770903.2016.1274402
Rosenberg SL, Miller GE, Brehm JM, Celedón JC (2014) Stress and asthma: novel insights on genetic, epigenetic, and immunologic mechanisms. J Allergy Clin Immun 134:1009–1015. https://doi.org/10.1016/j.jaci.2014.07.005
Saif Z, Hodyl NA, Hobbs E, Tuck AR, Butler MS, Osei-Kumah A, Clifton VL (2014) The human placenta expresses multiple glucocorticoid receptor isoforms that are altered by fetal sex, growth restriction and maternal asthma. Placenta 35:260–268. https://doi.org/10.1016/placenta.2014.01.012
Sandberg S, Rutter M, Giles S, Owen A, Champion L, Nicholls J, Prior V, McGuinness D, Drinnan D (1993) Assessment of psychosocial experiences in childhood: methodological issues and some illustrative findings. J Child Psychol Psychiatry 34:879–897
Sandberg S, Paton JY, Ahola S, McCann DC, McGuinness D, Hillary CR, Oja H (2000) The role of acute and chronic stress in asthma attacks in children. The Lancet 356:982–987
Sandberg S, McCann DC, Ahola S, Oja H, Paton JY, McGuinness D (2002) Positive experiences and the relationship between stress and asthma in children. Acta Paed 91:152–158
Sandberg S, Järvenpää S, Penttinen A, Paton JY, McCann DC (2004) Asthma exacerbations in children immediately following stressful life events: a Cox’s hierarchical regression. Thorax 59:1046–1051. https://doi.org/10.1136/thx.2004.024604
Shanahan L, Copeland WE, Worthman CM, Angold A, Costello EJ (2013) Children with both asthma and depression are at risk for heightened inflammation. J Pediatr 163:1443–1447. https://doi.org/10.1016/J.jpeds.2013.06.046
Shankardass K, McConnell R, Jerrett M, Milam J, Richardson J, Berhane K (2009) Parental stress increases the effect of traffic-related air pollution on childhood asthma incidence. PNAS 106:12406–12411. https://doi.org/10.1073/pnas.0812910106
Silva N, Crespo C, Carona C, Canavarro M (2015) Mapping the caregiving process in paediatric asthma: parental burden, acceptance and denial coping strategies and quality of life. Psychol Health 30:949–968. https://doi.org/10.1080/08870446.2015.1007981
Tobin ET, Kane HS, Saleh DJ, Wildman DE, Breen EC, Secord E, Statcher RB (2015) Astma-related immune responses in youth with asthma: associations with maternal responsiveness and expressions of positive and negative affect in daily life. Psychosom Med 77:892–902. https://doi.org/10.1097/PSY.0000000000000236
Trump S, Bieg M, Gu Z, Thürmann L, Bauer T, Bauer M, Ishaque N, Röder S, Gu L, Herberth G, Lawerenz C, Borte M, Schlesner M, Plass C, Diessl N, Eszlinger M, Mücke O, Elvers H-D, Wissenbach DK, von Bergen M, Herrmann C, Weichenhan D, Wright RJ, Lehmann I, Eils R (2016) Nature Scientific Reports 6:28616. https://doi.org/10.1038/srep28616
van de Loo KFE, van Gelder MMHJ, Roukema J, Roeleveld N, Markus PJFM, Verhaak CM (2016) Prenatal maternal psychological stress and childhood asthma and wheezing: a meta-analysis. Eur Respir J 47:133–146. https://doi.org/10.1183/13993003.00299-2015
Wood BL, Miller BD, Lehman HK (2015) Review of family relational stress and pediatric asthma: the value of biopsychosocial systemic models. Family Process 54:376–389. https://doi.org/10.1111/famp.12139
Wright RJ (2011) Epidemiology of stress and asthma: from constricting communities and fragile families to epigenetics. Immunol Allergy Clin 31:19–39. https://doi.org/10.1016/j.iac.2010.09.011
Zijlmans MAC, Korpela K, Riksen-Walraven JM, de Vos WM, de Weerth C (2015) Maternal prenatal stress is associated with infant intestinal microbiota. Psychoneuroendocrinology 53:233–245
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Sandberg, S. (2020). Chronic Illness: Asthma. In: Taylor, E., Verhulst, F., Wong, J., Yoshida, K. (eds) Mental Health and Illness of Children and Adolescents. Mental Health and Illness Worldwide. Springer, Singapore. https://doi.org/10.1007/978-981-10-2348-4_31
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