Skip to main content

Childhood Polyarteritis Nodosa

  • Chapter
  • First Online:
Pediatric Rheumatology
  • 1614 Accesses

Abstract

To learn how to diagnose systemic and cutaneous polyarteritis nodosa (PAN) and to distinguish them from other secondary vasculitides.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kϋssmaul AMK. ϋber eine bisher nicht beschriebene igenthϋmliche Arterinerkrankung (Periatrteritis nodossa). Dsch Arch Klin Med. 1866;1:484.

    Google Scholar 

  2. Lightfoot Jr RW, Michel BA, Bloch DA, Hunder GG, Zvaifler NJ, McShane DJ, et al. The American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. Arthritis Rheum. 1990;33(8):1088–93.

    Article  PubMed  Google Scholar 

  3. Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994;37(2):187–92.

    Article  CAS  PubMed  Google Scholar 

  4. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1–11.

    Article  CAS  PubMed  Google Scholar 

  5. Ozen S, Ruperto N, Dillon MJ, Bagga A, Barron K, Davin JC, et al. EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides. Ann Rheum Dis. 2006;65(7):936–41.

    Article  CAS  PubMed  Google Scholar 

  6. Ettlinger RE, Nelson AM, Burke EC, Lie JT. Polyarteritis nodosa in childhood a clinical pathologic study. Arthritis Rheum. 1979;22(8):820–5.

    Article  CAS  PubMed  Google Scholar 

  7. Ozen S, Anton J, Arisoy N, Bakkaloglu A, Besbas N, Brogan P, et al. Juvenile polyarteritis: results of a multicenter survey of 110 children. J Pediatr. 2004;145(4):517–22.

    Article  PubMed  Google Scholar 

  8. Ozen S, Bakkaloglu A, Dusunsel R, Soylemezoglu O, Ozaltin F, Poyrazoglu H, et al. Childhood vasculitides in Turkey: a nationwide survey. Clin Rheumatol. 2007;26(2):196–200.

    PubMed  Google Scholar 

  9. Mahr A, Guillevin L, Poissonnet M, Ayme S. Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener’s granulomatosis, and Churg-Strauss syndrome in a French urban multiethnic population in 2000: a capture-recapture estimate. Arthritis Rheum. 2004;51(1):92–9.

    Article  PubMed  Google Scholar 

  10. Tervaert JW, Popa ER, Bos NA. The role of superantigens in vasculitis. Curr Opin Rheumatol. 1999;11(1):24–33.

    Article  CAS  PubMed  Google Scholar 

  11. Brogan PA, Shah V, Bagga A, Klein N, Dillon MJ. T cell Vbeta repertoires in childhood vasculitides. Clin Exp Immunol. 2003;131(3):517–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, et al. Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med. 2014;370(10):911–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Navon Elkan P, Pierce SB, Segel R, Walsh T, Barash J, Padeh S, et al. Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy. N Engl J Med. 2014;370(10):921–31.

    Article  PubMed  Google Scholar 

  14. Jennette JC, Falk RJ. The role of pathology in the diagnosis of systemic vasculitis. Clin Exp Rheumatol. 2007;25(1 Suppl 44):S52–6.

    CAS  PubMed  Google Scholar 

  15. Miller DL. Angiography in polyarteritis nodosa. AJR Am J Roentgenol. 2000;175(6):1747–8.

    Article  CAS  PubMed  Google Scholar 

  16. Falcini F, La Torre F, Vittadello F, Rigante D, Martini G, Corona F, et al. Clinical overview and outcome in a cohort of children with polyarteritis nodosa. Clin Exp Rheumatol. 2014;32(3 Suppl 82):S134–7.

    PubMed  Google Scholar 

  17. Marzano AV, Vezzoli P, Berti E. Skin involvement in cutaneous and systemic vasculitis. Autoimmun Rev. 2013;12(4):467–76.

    Article  PubMed  Google Scholar 

  18. Guillevin L, Lhote F, Gallais V, Jarrousse B, Royer I, Gayraud M, et al. Gastrointestinal tract involvement in polyarteritis nodosa and Churg-Strauss syndrome. Ann Med Interne. 1995;146(4):260–7.

    CAS  Google Scholar 

  19. Engel DG, Gospe Jr SM, Tracy KA, Ellis WG, Lie JT. Fatal infantile polyarteritis nodosa with predominant central nervous system involvement. Stroke J Cereb Circ. 1995;26(4):699–701.

    Article  CAS  Google Scholar 

  20. Topaloglu R, Besbas N, Saatci U, Bakkaloglu A, Oner A. Cranial nerve involvement in childhood polyarteritis nodosa. Clin Neurol Neurosurg. 1992;94(1):11–3.

    Article  CAS  PubMed  Google Scholar 

  21. Bakkaloglu A, Ozen S, Baskin E, Besbas N, Gur-Guven A, Kasapcopur O, et al. The significance of antineutrophil cytoplasmic antibody in microscopic polyangiitis and classic polyarteritis nodosa. Arch Dis Child. 2001;85(5):427–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Brogan PA, Davies R, Gordon I, Dillon MJ. Renal angiography in children with polyarteritis nodosa. Pediatr Nephrol (Berlin, Germany). 2002;17(4):277–83.

    Article  Google Scholar 

  23. Ha HK, Lee SH, Rha SE, Kim JH, Byun JY, Lim HK, et al. Radiologic features of vasculitis involving the gastrointestinal tract. Radiographics Rev Publ Radiol Soc N Am Inc. 2000;20(3):779–94.

    CAS  Google Scholar 

  24. Schmidt WA. Use of imaging studies in the diagnosis of vasculitis. Curr Rheumatol Rep. 2004;6(3):203–11.

    Article  PubMed  Google Scholar 

  25. Ozaki K, Miyayama S, Ushiogi Y, Matsui O. Renal involvement of polyarteritis nodosa: CT and MR findings. Abdom Imaging. 2009;34(2):265–70.

    Article  PubMed  Google Scholar 

  26. Basoglu T, Akpolat T, Canbaz F, Bernay I, Albayrak S, Kilic M, et al. Tc-99m DMSA renal scan in polyarteritis nodosa with bilateral intraparenchymal renal artery aneurysms. Clin Nucl Med. 1999;24(3):201–2.

    Article  CAS  PubMed  Google Scholar 

  27. Fauci AS, Katz P, Haynes BF, Wolff SM. Cyclophosphamide therapy of severe necrotizing vasculitis. N Engl J Med. 1979;301:235–8.

    Article  CAS  PubMed  Google Scholar 

  28. Reimold EW, Weinberg AG, Fink CW, Battles ND. Polyarteritis in children. Am J Dis Child. 1976;130(5):534–41.

    CAS  PubMed  Google Scholar 

  29. Dillon MJ. Vasculitis treatment – new therapeutic approaches. Eur J Pediatr. 2006;165(6):351–7.

    Article  PubMed  Google Scholar 

  30. Eleftheriou D, Melo M, Marks SD, Tullus K, Sills J, Cleary G, et al. Biologic therapy in primary systemic vasculitis of the young. Rheumatology (Oxford). 2009;48(8):978–86.

    Article  CAS  Google Scholar 

  31. Wright E, Dillon MJ, Tullus K. Childhood vasculitis and plasma exchange. Eur J Pediatr. 2007;166(2):145–51.

    Article  PubMed  Google Scholar 

  32. de Kort SW, van Rossum MA, ten Cate R. Infliximab in a child with therapy-resistant systemic vasculitis. Clin Rheumatol. 2006;25(5):769–71.

    Article  PubMed  Google Scholar 

  33. Al-Bishri J, le Riche N, Pope JE. Refractory polyarteritis nodosa successfully treated with infliximab. J Rheumatol. 2005;32(7):1371–3.

    PubMed  Google Scholar 

  34. Ribeiro E, Cressend T, Duffau P, Grenouillet-Delacre M, Rouanet-Lariviere M, Vital A, et al. Rituximab efficacy during a refractory polyarteritis nodosa flare. Case Rep Med. 2009;2009:738293.

    PubMed  Google Scholar 

  35. Campanilho-Marques R, Ramos F, Canhao H, Fonseca JE. Remission induced by infliximab in a childhood polyarteritis nodosa refractory to conventional immunosuppression and rituximab. Joint Bone Spine Revue du Rhum. 2014;81(3):277–8.

    Article  Google Scholar 

  36. Hampson LV, Whitehead J, Eleftheriou D, Tudur-Smith C, Jones R, Jayne D, et al. Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa. PLoS One. 2015;10(3):e0120981.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Guillevin L, Lhote F, Gayraud M, Cohen P, Jarrousse B, Lortholary O, et al. Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients. Medicine. 1996;75(1):17–28.

    Article  CAS  PubMed  Google Scholar 

  38. Gayraud M, Guillevin L, le Toumelin P, Cohen P, Lhote F, Casassus P, et al. Long-term followup of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: analysis of four prospective trials including 278 patients. Arthritis Rheum. 2001;44(3):666–75.

    Article  CAS  PubMed  Google Scholar 

  39. Guillevin L, Pagnoux C, Seror R, Mahr A, Mouthon L, Le Toumelin P. The five-factor score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort. Medicine. 2011;90(1):19–27.

    Article  PubMed  Google Scholar 

  40. Magilavy DB, Petty RE, Cassidy JT, Sullivan DB. A syndrome of childhood polyarteritis. J Pediatr. 1977;91(1):25–30.

    Article  CAS  PubMed  Google Scholar 

  41. Cheung YF, Brogan PA, Pilla CB, Dillon MJ, Redington AN. Arterial distensibility in children and teenagers: normal evolution and the effect of childhood vasculitis. Arch Dis Child. 2002;87(4):348–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Blacher J, Asmar R, Djane S, London GM, Safar ME. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension. 1999;33(5):1111–7.

    Article  CAS  PubMed  Google Scholar 

  43. Demirkaya E, Ozen S, Pistorio A, Galasso R, Ravelli A, Hasija R, et al. Performance of Birmingham Vasculitis Activity Score and disease extent index in childhood vasculitides. Clin Exp Rheumatol. 2012;30(1 Suppl 70):S162–8.

    PubMed  Google Scholar 

  44. Fidanci BE, Demirkaya E, Acikel C, Fidanci K, Karaman D, Yildiz D, et al. The invisible part of the iceberg: qualitative aspects of childhood vasculitis. Clin Exp Rheumatol. 2014;32(3 Suppl 82):S122–7.

    PubMed  Google Scholar 

  45. Lindberg K. Ein Beitrag zur Kenntnis der Periarteritis nodosa. Acta Med Scand. 1931;76:183–225.

    Article  Google Scholar 

  46. Borrie P. Cutaneous polyarteritis nodosa. Br J Dermatol. 1972;87(2):87–95.

    Article  CAS  PubMed  Google Scholar 

  47. Moreland LW, Ball GV. Cutaneous polyarteritis nodosa. Am J Med. 1990;88(4):426–30.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Manjari Agarwal .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media Singapore

About this chapter

Cite this chapter

Agarwal, M., Sawhney, S. (2017). Childhood Polyarteritis Nodosa. In: Sawhney, S., Aggarwal, A. (eds) Pediatric Rheumatology. Springer, Singapore. https://doi.org/10.1007/978-981-10-1750-6_37

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-1750-6_37

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-1749-0

  • Online ISBN: 978-981-10-1750-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics