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Detecting Targets Without Thermal Cycling in Food: Isothermal Amplification and Hybridization

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Functional Nucleic Acids Detection in Food Safety

Abstract

Isothermal technology is an option for point-of-care diagnosis to replace PCR amplification. Recently, this approach has been updated into a simple, rapid, and cost-effective tool. The input can be defined as DNA, RNA, or certain artificial nucleic acids, and the output response can be an amplified signal or catalytic chemical reaction, which allowing biosensing assays on various classes of biomolecules. The isothermal technologies used in the food safety detection can be classified into the following two categories: amplification and hybridization. Each category includes various methods designed to achieve a rapid and sensitive diagnose. Additionally, isothermal methods have made progress in the single cell analysis due to the unbiased, linear nature of the amplification process. This review mainly describes specific isothermal detection techniques to give a better understanding of the method of choice when performing fast and simple point-of-care detection.

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Acknowledgments

This work is supported by the Ministry of Science and Technology of Beijing (XX2014B069). Many thanks to Chenguang Wang for his kindly help in the manuscript conception and preparation.

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  1. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China

    Wentao Xu

  2. Beijing Laboratory for Food Quality and Safety, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China

    Wentao Xu

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Xu, W. (2016). Detecting Targets Without Thermal Cycling in Food: Isothermal Amplification and Hybridization. In: Functional Nucleic Acids Detection in Food Safety. Springer, Singapore. https://doi.org/10.1007/978-981-10-1618-9_10

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