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A Binuclear Gold(I) Complex with Mixed Bridging Diphosphine and Bis(N-Heterocyclic Carbene) Ligands Shows Favorable Thiol Reactivity and Effectively Inhibits Tumor Growth and Angiogenesis In Vivo

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Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

Part of the book series: Springer Theses ((Springer Theses))

Abstract

By virtue of appealing features such as strong σ donors to allow formation of stable metal–carbon (M-C) bond(s), stable N-heterocyclic carbenes (NHCs) have demonstrated profound impact in diverse areas of chemistry. Less developed but with burgeoning interests in recent years is the medicinal application of metal–NHC complexes in the treatment of cancer.

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  1. Department of Chemistry, The University of Hong Kong, Hong Kong, China

    Taotao Zou

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Zou, T. (2016). A Binuclear Gold(I) Complex with Mixed Bridging Diphosphine and Bis(N-Heterocyclic Carbene) Ligands Shows Favorable Thiol Reactivity and Effectively Inhibits Tumor Growth and Angiogenesis In Vivo. In: Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II). Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-10-0657-9_4

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