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Molecular Bioindicators of Pollution in Fish

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Environmental Indicators

Abstract

The use of microarrays to assess pollutant responses in aquatic organisms has become widespread. In the field of ecotoxicology, the development of microarrays for fish models has served to advance our understanding of the mechanisms of action of numerous chemicals, including both those that are well studied and those that are emerging, singly in controlled laboratory settings, and in complex mixtures and field settings. This chapter chronicles the advent of using microarrays in the study of fish and provides notable examples of both laboratory and field studies where microarrays were instrumental in answering important contaminant-driven hypotheses. These examples will highlight how microarrays have been effective in defining unexpected actions and pathways of well-studied chemicals and in the toxicological assessment of emerging pollutants including nanomaterials, and whether this technology is useful for defining the response to complex mixtures in field settings. Global transcriptional data sets may help define key events for new state-of-the-art modeling of adverse outcome pathways (AOPs).

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Acknowledgements

This work was supported by the Superfund Research Project from the National Institute of Environmental Health Sciences, NIEHS (RO1 ES015449) and by the National Science Foundation (NSF CBET 1236029).

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Authors and Affiliations

  1. Department of Physiological Sciences, University of Florida, Gainesville, FL, 32611, USA

    Nancy D. Denslow

  2. Environmental and Global Health, University of Florida, Gainesville, FL, 32611, USA

    Tara Sabo-Attwood

  3. Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, 32611, USA

    Nancy D. Denslow & Tara Sabo-Attwood

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  1. Nancy D. Denslow
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  2. Tara Sabo-Attwood
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Correspondence to Nancy D. Denslow .

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Editors and Affiliations

  1. Civil and Environmental Engineering, Israel Institute of Technology Technion, Haifa, Israel

    Robert H. Armon

  2. Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

    Osmo Hänninen

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Denslow, N.D., Sabo-Attwood, T. (2015). Molecular Bioindicators of Pollution in Fish. In: Armon, R., Hänninen, O. (eds) Environmental Indicators. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9499-2_40

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