Skip to main content

In Vivo Metabolism of Danshen and Its Preparations

  • Chapter
  • First Online:
Dan Shen (Salvia miltiorrhiza) in Medicine

Abstract

Danshen and its preparations are widely used for the treatment of cardiovascular and cerebrovascular diseases, with remarkable curative effects. However, there are few research reports on their in vivo metabolism. Studies in this area can elucidate the mechanisms of action of Danshen’s active components, and provide a scientific basis for the clinical application of Danshen and Danshen preparations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Sun LP, Xiong W, Zheng Z, et al. West China J Pharm Sci. 2004;19:24–8.

    Google Scholar 

  2. Hei MY, Yin P, Kuang SJ. J Clin Res. 2004;21:876–80.

    CAS  Google Scholar 

  3. Chen LJ, Li T, Li C. J Chin Med Mater. 2003;26:504–6.

    Google Scholar 

  4. Tang Z, Tang Y, Fu LB. J First Mil Med Univ. 2003;23:595–8.

    CAS  Google Scholar 

  5. Ye LB, Xi T, Chen F, et al. J Chin Pharm Univ. 2004;35:267–70.

    CAS  Google Scholar 

  6. Yuan SL, Song Y, Wang XJ, et al. West China J Pharm Sci. 2003;18:327–31.

    CAS  Google Scholar 

  7. Qin P, Qu Y. J West China Med Univ. 2002;33:370–97.

    Google Scholar 

  8. Xia WJ, Xiang P, Zhang LR, et al. Chin J Pathophysiol. 2003;19:865–8.

    CAS  Google Scholar 

  9. Zuo Q, Zhang PH, Luo SJ, et al. Guangdong Med. 2004;25:636–9.

    CAS  Google Scholar 

  10. Zhu JR, Luo HW. J Chin Pharm Univ. 2004;35:368–72.

    CAS  Google Scholar 

  11. Hu MX, Zhou MS, Hu XM, et al. Chin Pharmacol Bull. 2006;22:436–40.

    CAS  Google Scholar 

  12. Sun XG, Jia JH, Chen YY. Shandong J Chin Tradit Med. 2000;19:358–60.

    Google Scholar 

  13. Drug Evaluation Center of SFDA. Guideline on Preclinical Pharmacokinetics studies of chemical drugs. 2001.

    Google Scholar 

  14. Xiao C, Chen JX. Chin Pharm J. 1993;24:425–6.

    Google Scholar 

  15. Shah VP, Midha KK, Dighe S, et al. J Pharm Sci. 1992;81:309–12.

    Article  Google Scholar 

  16. Karnes HT, March C. Pharm Ires. 1993;10:1420–2.

    Article  CAS  Google Scholar 

  17. Zhang J, Huang M, Guan S, et al. J Pharmacol Exp Ther. 2006;317:1285–94.

    Article  PubMed  CAS  Google Scholar 

  18. Yuan Y, Jiang XH, Zhou J, et al. West China J Pharm Sci. 2002;17:246–8.

    Google Scholar 

  19. Hao H, Wang G, Cui N, et al. Planta Ivied. 2006;72:1311–7.

    CAS  Google Scholar 

  20. Hao H, Wang G, Li P, et al. J Pharm Biomed Anal. 2006;40:382–8.

    Article  PubMed  CAS  Google Scholar 

  21. Song M, Hang TJ, Zhang ZhX, et al. J Chromatogr B. 2005;827(205):209.

    Google Scholar 

  22. Xue M, Cui Y, Wang HQ, et al. J Pharm Biomed Anal. 1999;21:207–13.

    Article  PubMed  Google Scholar 

  23. Bi HC, Law FC, Zhong GP, et al. Biomed Chromatogr, 2007 Mar l4. (in press).

    Google Scholar 

  24. Okumura Y, Kakisawa H, Kato M, et al. Bull Chem Soc Jpn. 1961;34:895–7.

    Article  CAS  Google Scholar 

  25. Baillie AC, Thomson RH. J Chem Soc. 1968;12:48–52.

    Google Scholar 

  26. Takium K, Koizumi K. Chem Pharm Bull. 1962;10:112–6.

    Article  Google Scholar 

  27. Romanova AS, Patudin AV, Pervykh LN, et al. Khimba Prirodnykh Soedinenii. 1978;4:515–6.

    Google Scholar 

  28. Qian Mk, Yang PC, Chin KC, et al. Yaoxue Tongbao 1980; 15:1–5.

    Google Scholar 

  29. Ryu SY, No Z, Kim SH, et al. Planta Med. 1997;63:44–6.

    Article  PubMed  CAS  Google Scholar 

  30. Liu AH, Lin YH, Yang M, et al. J Chromatogr B. 2007;846:32–41.

    Article  CAS  Google Scholar 

  31. Hu P, Luo GA, Zhao ZZ, et al. Chem Pharm Bull. 2005;53:705–9.

    Article  PubMed  CAS  Google Scholar 

  32. Pan JY, Cheng YY. J Pharm Biomed Anal. 2006;42:565–72.

    Article  PubMed  CAS  Google Scholar 

  33. Yang M, Liu AH, Guan SH, et al. Rapid Commun Mass Spectrom. 2006;20:1266–80.

    Article  PubMed  CAS  Google Scholar 

  34. Mao SJ, Hou SX, Liang Z, et al. J Chromatogr B. 2006;831:163–8.

    Article  CAS  Google Scholar 

  35. Li P, Wang GJ, Li J, et al. J Mass Spectrom. 2006;41:670–84.

    Article  PubMed  CAS  Google Scholar 

  36. He Q, Hu XJ, Cheng YY. J Pharrn Biomed Anal. 2006;41:485–92.

    Article  CAS  Google Scholar 

  37. Luo HW, Sheng LS, Zhang SQ, et al. Acta Pharm Sinica. 1983;18:1–6.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Dean Guo , Dean Guo , Dean Guo , Dean Guo , Dean Guo , Dean Guo or Dean Guo .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Liu, A., Guo, D., Zhang, J., Sun, J. (2015). In Vivo Metabolism of Danshen and Its Preparations. In: Yan, X. (eds) Dan Shen (Salvia miltiorrhiza) in Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9463-3_17

Download citation

Publish with us

Policies and ethics